Transcriptional Control of Gene Expression in Hepatic Cells

  • Gennaro Ciliberto
  • Vittorio Colantuoni
  • Raffaele De Francesco
  • Vincenzo De Simone
  • Paolo Monaci
  • Alfredo Nicosia
  • Dipak P. Ramji
  • Carlo Toniatti
  • Riccardo Cortese
Part of the Progress in Gene Expression book series (PRGE)


In this chapter, we review the regulation of gene expression in hepatic cells, with emphasis on the cis-acting elements located in the proximal promoter region and on the properties of the transcriptional factors active in liver.


Hepatic Cell Albumin Gene Argininosuccinate Synthetase Liver Gene Expression Tyrosine Aminotransferase Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Adams BS, Leung K, Hanley EW, Nabel GJ (1991): Cloning of RttB, a novel DNA-binding protein that recognizes the interleukin-2 receptor a chain κB site. New Biol 3:1063–1073.Google Scholar
  2. Adams JM, Cory S (1991): Transgenic models of tumor development. Science 254:1161–1167.CrossRefGoogle Scholar
  3. Akira S, Isshiki H, Sugita T, Tanabe O, Kinoshita S, Nishio Y, Nakajima T, Hirano T, Kishimoto T (1990): A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J 9:1897–1906.Google Scholar
  4. Arcone R, Guaiandi G, Ciliberto G (1988): Identification of sequences responsible for acute-phase induction of human C-reactive protein. Nucleic Acids Res 16:3195–3207.CrossRefGoogle Scholar
  5. Aufiero B, Schneider RJ (1990): The hepatitis B virus X-gene product trans-activates both RNA polymerase II and III promoters. EMBO J 9:497–504.Google Scholar
  6. Babiss LE, Herbst RS, Bennett AL, Darnell JE Jr (1987): Factors that interact with the rat albumin promoter are present both in hepatocytes and other cell types. Genes & Dev 1:256–267.CrossRefGoogle Scholar
  7. Baeuerle PA, Baltimore D (1988a): Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kB transcription factor. Cell 53:211–217.CrossRefGoogle Scholar
  8. Baeuerle PA, Baltimore D (1988b): I-kB: A specific inhibitor of the NF-kB transcription factor. Science 242:540–546.CrossRefGoogle Scholar
  9. Baeuerle PA, Baltimore D (1989): A 65-kD subunit of active NF-kB is required for inhibition of NF-kB by I-kB. Genes & Dev 3:1689–1698.CrossRefGoogle Scholar
  10. Baldwin AS Jr, LeClair KP, Singh H, Sharp PA (1990): A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes. Mol Cell Biol 10:1406–1414.Google Scholar
  11. Ballard DW, Walker WH, Doerre S, Sista P, Molitor JA, Dixon EP, Peffer NJ, Hannik M, Greene WC (1990): The V-rel oncogenes encodes a kB enhancer binding protein that inhibits NF-kB function. Cell 63:803–814.CrossRefGoogle Scholar
  12. Baumann H (1989): Hepatic acute phase reaction in vivo and in vitro. In Vitro Cell Dev Biol 25:115–126.CrossRefGoogle Scholar
  13. Baumann H, Schendel P (1991): Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6. J Biol Chem 266:20424–20427.Google Scholar
  14. Baumann H, Wong GG (1989): Hepatocyte-stimulating factor III shares structural and functional identity with leukemia inhibitory factor. J Immunol 143:1163–1167.Google Scholar
  15. Baumann H, Richards C, Gauldie J (1987a): Interaction among hepatocyte-stimulating factors, interleukin-1 and glucocorticoids for the regulation of acute phase plasma proteins in human hepatoma (HEPG2) cells. J Immunol 139:2144–4128.Google Scholar
  16. Baumann H, Onorato V, Gauldie J, Jahreis GP (1987b): Distinct sets of acute phase plasma proteins are stimulated by separate human hepatocyte-stimulating factors and monokines in rat hepatoma cells. J Biol Chem 262:9756–9768.Google Scholar
  17. Baumhueter S, Courtois G, Crabtree GR (1988): A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the β fibrinogen gene promoter as HNF-1. EMBO J 7:2485–2493.Google Scholar
  18. Baumhueter S, Mendel DB, Conley PB, Kuo CJ, Turk C, Graves MK, Edwards CA, Courtois G, Crabtree GR (1990): HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. Genes & Dev 4:372–379.CrossRefGoogle Scholar
  19. Becker PB, Gloss B, Schmid W, Strähle U, Schütz G (1986): In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone. Nature (Lond) 324:686–688.CrossRefGoogle Scholar
  20. Beekman JM, Wijnholds J, Schippers IJ, Pot W, Gruber M, Ab G (1991): Regulatory elements and DNA-binding proteins mediating transcription from the chicken very-low-density apolipoprotein II gene. Nucleic Acids Res 19:5371–5377.CrossRefGoogle Scholar
  21. Ben Ze’ev A, Robinson GS, Bucher NLR, Farmer SR (1988): Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc Natl Acad Sci USA 85:2161–2165.CrossRefGoogle Scholar
  22. Ben-Levy R, Faktor O, Berger I, Shaul Y (1989): Cellular factors that interact with the hepatitis B virus enhancer. Mol Cell Biol 9:1804–1809.Google Scholar
  23. Benvenisty N, Nechushtan H, Cohen H, Reshef L (1989): Separate cis-regulatory elements confer expression of phosphoenolpyruvate carboxykinase (GTP) gene in different cell lines. Proc Natl Acad Sci USA 86:1118–1122.CrossRefGoogle Scholar
  24. Birkenmeier EH, Gwynn B, Howard S, Jerry J, Gordon JI, Landschultz WH, McKnight SL (1989): Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes & Dev 3:1146–1156.CrossRefGoogle Scholar
  25. Blum HE, Gerok W, Vyas GN (1989): The molecular biology of hepatitis B virus. Trends Genet 5:15–158.CrossRefGoogle Scholar
  26. Bortolotti R, Weiss MC (1972a): Expression of differentiated functions in hepatoma cell hybrids. II. Aldolase. J Cell Physiol 79:211–224.CrossRefGoogle Scholar
  27. Bortolotti R, Weiss MC (1972b): Expression of differentiated functions in hepatoma cell hybrids. VI. Extinction and reexpression of liver alcohol dehydrogenase. Biochimie 54:195–201.CrossRefGoogle Scholar
  28. Boshart M, Weih F, Nichols M, Schuetz G (1991): The tissue-specific extinguisher locus Tse-1 encodes a regulatory subunit of cAMP-dependent protein kinase. Cell 66:849–859.CrossRefGoogle Scholar
  29. Boshart M, Weih F, Schmidt A, Fournier REK, Schuetz G (1990): A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Cell 61:905–916.CrossRefGoogle Scholar
  30. Brasier AR, Ron D, Tate JE, Habener JF (1990a): Synergistic enhancers located within an acute phase responsive enhancer modulate glucocorticoid induction of angiotensinogen gene transcription. Mol Endocrinol 4:1921–1933.CrossRefGoogle Scholar
  31. Brasier AR, Ron D, Tate JE, Habener JF (1990b): A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-la induced, NFkB mediated trans-activation of the angiotensinogen gene acute-phase response element. EMBO J 9:3933–3944.Google Scholar
  32. Bressac B, Kew M, Wands J, Ozturk M (1991): Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature (Lond) 350:429–431.CrossRefGoogle Scholar
  33. Briët E, Bertina RM, van Tilburg NH, Veltkamp JJ (1982): Hemophilia B Leyden. A sex-linked hereditary disorder that improves after puberty. N Eng J Med 306:788–790.CrossRefGoogle Scholar
  34. Brooks AR, Blackhart BD, Haubold K, Levy-Wilson B (1991): Characterization of tissue-specific enhancer elements in the second intron of the human apolipoprotein B gene. J Biol Chem 266:7848–7859.Google Scholar
  35. Brunei F, Ochoa A, Schaeffer E, Boissier F, Guillou Y, Cereghini S, Cohen GN, Zakin MM (1988): Interactions of DNA-binding proteins with the 5′ region of the human transferrin gene. J Biol Chem 263:10180–10185.Google Scholar
  36. Bulla GA, De Simone V, Cortese R, Fournier REK (1992): Extinction of α 1 -antitrypsin gene expression in somatic cell hybrids: Evidence for multiple controls. Genes & Dev 6:316–327.CrossRefGoogle Scholar
  37. Bulla GA, Siddiqui A (1988): The hepatitis B virus enhancer modulates transcription of the hepatitis B virus surface antigen gene from an internal location. J Virol 62:1437–1441.Google Scholar
  38. Burch JBE, Evans M, Friedman TM, O’Malley PJ (1988): Two functional estrogen response elements are located upstream of the major chicken vitellogenin gene. Mol Cell Biol 8:1123–1131.Google Scholar
  39. Butel JS, Sepulveda AR, Finegold MJ, Woo SLC (1990): SV40 large T antigen directed by regulatory elements of the human alpha-1-antitrypsin gene. Intervirology 31:85–100.Google Scholar
  40. Cao Z, Umek RM, McKnight SL (1991): Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes & Dev 5:1538–1552.CrossRefGoogle Scholar
  41. Carlson JA, Rogers BB, Sifers RN, Finegold MJ, Clift SM, DeMayo FJ, Bullock DW, Woo SLC (1989): Accumulation of PiZ alpha1-antitrypsin causes liver damage in transgenic mice. J Clin Invest 83:1183–1190.CrossRefGoogle Scholar
  42. Cascio S, Zaret KS (1991): Hepatocyte differentiation initiates during endoder-mal-mesenchymal interactions prior to liver formation. Development 113: 217–225.Google Scholar
  43. Castell JV, Gomez-Lechon MJ, David M, Hirano T, Kishimoto T, Heinrich PC (1988): Recombinant human interleukin-6 (IL-6, BSF-2, HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett 232:347–350.CrossRefGoogle Scholar
  44. Cato ACB, Heitlinger E, Ponta H, Hitpass LK, Ryffel GU, Bailly A, Rauch C, Milgrom E (1988): Estrogen and progesterone receptor-binding sites on the chicken vitellogenin II gene: synergism of steroid hormone action. Mol Cell Biol 8:5323–5330.Google Scholar
  45. Caselmann WH, Meyer M, Kekulé AS, Lauer V, Hofschneider PH, Koshy R (1990): A trans-activator function is generated by integration of hepatitis B virus pre S/S sequences in human hepatocellular carcinoma DNA. Proc Natl Adac Sci USA 87:2970–2974.CrossRefGoogle Scholar
  46. Cereghini S, Blumenfeld M, Yaniv M (1988): A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells. Genes & Dev 2:957–974.CrossRefGoogle Scholar
  47. Cereghini S, Yaniv M, Cortese R (1990): Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J 9:2257–2263.Google Scholar
  48. Cereghini S, Raymondjean M, Garcia-Carranca A, Herbomel P, Yaniv M (1987): Factors involved in control of tissue-specific expression of albumin gene. Cell 50:627–638.CrossRefGoogle Scholar
  49. Ceska TA, Lamers M, Monaci P, Nicosia A, Cortese R, Suck D (1993): The structure of a variant homeodomian present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding. EMBO J, in press.Google Scholar
  50. Chajek-Shaul T, Hayer T, Walsh A, Breslow JL (1991): Expression of the human apolipoprotein A-I gene in transgenic mice alters high density lipoprotein (HDL) particle size distribution and diminishes selective uptake of HDL cholesteryl esters. Proc Natl Acad Sci USA 88:6731–6735.CrossRefGoogle Scholar
  51. Chambaz J, Cardot P, Pastier D, Zannis VI, Cladaras C (1991): Promoter elements and factors required for hepatic transcription of the human ApoA-II gene. J Biol Chem 266:11676–11685.Google Scholar
  52. Chang C-J, Chen T-T, Xei H-Y, Chen D-S, Lee S-C (1990): Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol Cell Biol 10:6642–6653.Google Scholar
  53. Chang DJ, Paik Y-K, Leren TP, Walker DW, Howlett GJ, Taylor JM (1990): Characterization of a human apolipoprotein E gene enhancer element and its associated protein factors. J Biol Chem 265:9496–9504.Google Scholar
  54. Chang H-K, Ting L-P (1989): The surface gene promoter of the human hepatitis B virus displays a preference for differentiated hepatocytes. Virology 170:176–183.CrossRefGoogle Scholar
  55. Chang H-K, Wang B-Y, Yuh C-H, Wei C-L, Ting L-P (1989): A liver-specific nuclear factor interacts with the promoter region of the large surface protein gene of human hepatitis B virus. Mol Cell Biol 9:5189–5197.Google Scholar
  56. Chang T-C, Shapiro DJ (1989): An NFl-related vitellogenin activator element mediates transcription from the estrogen-regulated Xenopus laevis vitellogenin promoter. J Biol Chem 265:8176–8182.Google Scholar
  57. Chin AC, Fournier REK (1989): Tse-2: A trans-dominant extinguisher of albumin gene expression in hepatoma hybrid cells. Mol Cell Biol 9:3736–3743.Google Scholar
  58. Chisari FV, Filippi P, Buras J, McLachlan A, Popper H, Pinkert CA, Palmiter RD, Brinster RL (1987): Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice. Proc Natl Acad Sci USA 84:6909–6913.CrossRefGoogle Scholar
  59. Chisari FV, Klopchin K, Moriyama T, Pasquinelli C, Dunsford HA, Sell S, Pinkert CA, Brinster RL, Palmiter RD (1989): Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59:1145–1156.CrossRefGoogle Scholar
  60. Chouard T, Blumenfeld M, Bach I, Vandekerckhove J, Cereghini S, Yaniv M (1990): A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain. Nucleic Acids Res 18:5853–5863.CrossRefGoogle Scholar
  61. Christy RJ, Kaestner KH, Geiman DE, Lane MD (1991): CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci USA 88:2593–2597.CrossRefGoogle Scholar
  62. Christy RJ, Yang VW, Ntambi JM, Geiman DE, Landschulz WH, Friedman AD, Nakabeppu Y, Kelly TJ, Lane MD (1989): Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes & Dev 3:1323–1335.CrossRefGoogle Scholar
  63. Church GM, Ephrussi A, Gilbert W, Tonegawa S (1985): Cell-type-specific contacts to immunoglobulin enhancers in nuclei. Nature (Lond) 313:798–801.CrossRefGoogle Scholar
  64. Ciliberto G (1989): Transcriptional regulation of acute phase response genes with emphasis on the human C-reactive protein gene. In: Acute Phase Proteins and the Acute Phase Response, Pepys M, ed., pp. 29–46. New York: Springer-Verlag.CrossRefGoogle Scholar
  65. Ciliberto G, Arcone R, Wagner EF, Ruether U (1987): Inducible and tissue-specific expression of human C-reactive protein in transgenic mice. EMBO J 6:4017–4022.Google Scholar
  66. Citron BA, Davis MD, Milstein S, Gutierrez J, Mendel DB, Crabtree GR, Kaufman S (1992): Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of home-odomain proteins. Proc Natl Acad Sci USA 89:11891–11894.CrossRefGoogle Scholar
  67. Clayton DF, Darnell JE Jr (1983): Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocyte. Mol Cell Biol 3:1552–1561.Google Scholar
  68. Clayton DF, Harrelson AL, Darnell JE Jr (1985a): Dependence of liver-specific transcription on tissue organization. Mol Cell Biol 5:2623–2632.Google Scholar
  69. Clayton DF, Weiss M, Darnell JE Jr (1985b): Liver-specific RNA metabolism in hepatoma cells: variations in transcription rates and mRNA levels. Mol Cell Biol 5:2633–2641.Google Scholar
  70. Cognet M, Bergot M-O, Kahn A (1991): cis-Acting DNA elements regulating expression of the liver pyruvate kinase gene in hepatocytes and hepatoma cells. Evidence for tissue specific activators and extinguisher. J Biol Chem 266:7368–7375.Google Scholar
  71. Colgrove R, Simon G, Ganem D (1989): Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication. J Virol 63(9):4019–4026.Google Scholar
  72. Corthésy B, Claret F-X, Wahli W (1990): Estrogen receptor level determines sex-specific in vitro transcription from the Xenopus vitellogenin promoter. Proc Natl Acad Sci USA 87:7878–7882.CrossRefGoogle Scholar
  73. Corthésy B, Corthésy-Theulaz I, Cardinaux J-R, Wahli W (1991): A liver protein fraction regulating hormone-dependent in vitro transcription from the vitellogenin genes induces their expression in Xenopus oocytes. Mol Endocrinol 5:159–169.CrossRefGoogle Scholar
  74. Corthésy B, Hipskind R, Theulaz I, Wahli W (1988): Estrogen-dependent in vitro transcription from the vitellogenin promoter in liver nuclear extracts. Science 239:1137–1139.CrossRefGoogle Scholar
  75. Costa RH, Grayson DR, Darnell JE Jr (1989): Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and α 1 -antitrypsin genes. Mol Cell Biol 9:1415–1425.Google Scholar
  76. Costa RH, Grayson DR, Xanthopoulos KG, Darnell JE Jr (1988a): A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha-1-antitrypsin, albumin, and simian virus 40 genes. Proc Natl Acad Sci USA 85:3840–3844.CrossRefGoogle Scholar
  77. Costa RH, Lai E, Grayson DR, Darnell JE Jr (1988b): The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites. Mol Cell Biol 8:81–90.Google Scholar
  78. Costa RH, Van Dyke TA, Yan C, Kuo F, Darnell JE Jr (1990): Similarities in transthyretin gene expression and differences in transcription factors: Liver and yolk sac compared to choroid plexus. Proc Natl Acad Sci USA 87:6589–6593.CrossRefGoogle Scholar
  79. Courtois G, Baumhueter S, Crabtree GR (1988): Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters. Proc Natl Acad Sci USA 85:7937–7941.CrossRefGoogle Scholar
  80. Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR (1987): Interaction of a liver-specific nuclear factor with the fibrinogen and α 1 -antitrypsin promoters. Science 238:688–692.CrossRefGoogle Scholar
  81. Crossley M, Ludwig M, Starwell KM, De Vos P, Olek K, Brownlee GG (1992): Recovery from hemophilia B Leyden: an androgen-responsive element in the factor IV promoter. Science 257:377–379.CrossRefGoogle Scholar
  82. Crossley M, Brownlee GG (1990): Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B. Nature (Lond) 345:444–446.CrossRefGoogle Scholar
  83. Crossley M, Ludwig M, Stowell K, Olek K, Brownlee GG: A mutation in an LF-A1/HNF4 site unmasks an overlapping androgen responsive element and explains the clinical recovery of haemophilia B Leyden patients (in manuscript).Google Scholar
  84. Darlington GH, Wilson DR, Lachman LB (1986): Monocyte-conditioned medium, interleukin-1 and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. J Cell Biol 103:787–793.Google Scholar
  85. Davidson RL (1974): Gene expression in somatic cell hybrids. Annu Rev Genet 8:195–218.CrossRefGoogle Scholar
  86. Davidson RL, Ephrussi B, Yamamoto K (1968): Regulation of melanin synthesis in mammalian cells as studied by somatic hybridization. I. Evidence for negative control. J Cell Physiol 72:115–127.CrossRefGoogle Scholar
  87. Davis JN, Bargmann W, Bose HR Jr (1990): Identification of protein complexes containing the c-rel proto-oncogene product in avian hematopoietic cells. Oncogene 5:1109–1115.Google Scholar
  88. De Francesco R, Pastore A, Vecchio G, Cortese R (1991): Circular dichroism study on the conformational stability of the dimerization domain of transcription factor LFB-1. Biochemistry 30(1): 143–147.CrossRefGoogle Scholar
  89. De Simone V, Cortese R (1988): The transcriptional regulation of liver-specific gene expression. In: Oxford Surveys on Eukaryotic Genes, McLean N, ed, pp. 51–90. New York: Oxford University Press.Google Scholar
  90. De Simone V, Ciliberto G, Hardon E, Paonessa G, Palla F, Lundberg L, Cortese R (1987): Cis- and trans-acting elements responsible for the cell-specific expression of the human α 1-antitrypsin gene. EMBO J 6:2759–2766.Google Scholar
  91. De Simone V, De Magistris L, Lazzaro D, Gerstner J, Monaci P, Nicosia A, Cortese R (1991): LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is epxressed in specialized epithelia. EMBO J 10(6): 1435–1443.Google Scholar
  92. Dejean A, Bougueleret L, Grzeschik K-H, Tiollais P (1986): Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature (Lond) 322:70–72.CrossRefGoogle Scholar
  93. Dente L, Rüther U, Tripodi M, Wagner EF, Cortese R (1988): Expression of human α1-acid glycoprotein genes in cultured cells and in transgenic mice. Genes & Dev 2:259–266.CrossRefGoogle Scholar
  94. Deschatrette J, Fougere-Deschatrette C, Corcos L, Schimke RT (1985): Expression of the mouse serum albumin gene introduced into differentiated and dedifferentiated rat hepatoma cells. Proc Natl Acad Sci USA 82:765–769.CrossRefGoogle Scholar
  95. Descombes P, Schibler U (1991): A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569–579.CrossRefGoogle Scholar
  96. Descombes P, Chojkier M, Lichtsteiner S, Falvey E, Schibler U (1990): LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes & Dev 4:1541–1551.CrossRefGoogle Scholar
  97. Dewey MJ, Rheaume C, Berger FG, Baumann H (1990): Inducible and tissue-specific expression of rat α-acid glycoprotein in transgenic mice. J Immunol 144:4392–4398.Google Scholar
  98. Dikstein R, Faktor O, Ben-Levy R, Shaul Y (1990a): Functional organization of the hepatitis B virus enhancer. Mol Cell Biol 10:3683–3689.Google Scholar
  99. Dikstein R, Faktor O, Shaul Y (1990b): Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer. Mol Cell Biol 10:4427–4430.Google Scholar
  100. Di Persio CM, Jackson DA, Zaret KS (1991): The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology. Mol Cell Biol 11:4405–4414.Google Scholar
  101. Dubensky TW, Campbell BA, Villareal LP (1984): Direct transfection of viral and plasmid DNA into the liver or spleen of mice. Proc Natl Acad Sci USA 81:7529–7533.CrossRefGoogle Scholar
  102. Dunsford HA, Sell S, Chisari FV (1990): Hepatocarcinogenesis due to chronic liver cell injury in hepatitis B virus transgenic mice. Cancer Res 50:3400–3407.Google Scholar
  103. Dycaico MJ, Grant SGN, Felts K, Nichols WS, Geller SA, Hager JH, Pollard AJ, Kohler SW, Short HP, Jirik FR, Hanahan D, Sorge JA (1988): Neonatal hepatitis induced by α 1-antitrypsin: A transgenic mouse model. Science 242:1409–1412.CrossRefGoogle Scholar
  104. Edbrooke MR, Foldi J, Cheshire JK, Li F, Faulkes DJ, Woo P (1991): Constitutive and NF-/kB-like proteins in the regulation of the serum amyloid A gene by interleukin 1. Cytokines 3:380–388.CrossRefGoogle Scholar
  105. Faber S, Ip T, Granner D, Chalkley R (1991): The interplay of ubiquitous DNA-binding factors, availability of binding sites in the chromatin, and DNA methylation in the differential regulation of phosphoenolpyruvate carboxykinase gene expression. Nucleic Acids Res 19:4681–4688.CrossRefGoogle Scholar
  106. Faktor O, Budlovsky S, Ben-Levy R, Shaul Y (1990): A single element within the hepatitis B virus enhancer binds multiple proteins and responds to multiple stimuli. J Virol 64:1861–1863.Google Scholar
  107. Farza H, Hadchouel M, Scotto J, Tiollais P, Babinet C, Pourcel C (1988): Replication and gene expression of hepatitis B virus in a transgenic mouse that contains the complete viral genome. J Virol 62:4144–4152.Google Scholar
  108. Ferry N, Duplessis O, Houssin D, Danos O, Heard J-M (1991): Retroviral-mediated gene transfer into hepatocytes in vivo. Proc Natl Acad Sci USA 88:8377–8381.CrossRefGoogle Scholar
  109. Feuerman MH, Godbout R, Ingram RS, Tilghman SM (1989): Tissue-specific transcription of the mouse α-fetoprotein gene promoter is dependent on HNF-1. Mol Cell Biol 9:4204–4212.Google Scholar
  110. Fey GH, Gauldie J (1990): The acute phase response of the liver in inflammation. In: Progress in Liver Diseases, Popper H, Schaffner F, ed. Philadelphia: WB Saunders.Google Scholar
  111. Fields S, Jang SK (1990): Presence of a potent transcription activating sequence in the p53 protein. Science 24:1046–1049.CrossRefGoogle Scholar
  112. Finney M (1990): The homeodomain of the transcription factor LF-B1 has a 21 amino acid loop between helix 2 and helix 3. Cell 60:5–6.CrossRefGoogle Scholar
  113. Forest CD, O’Brien RM, Lucas PC, Magnuson MA, Granner DK (1990): Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Mol Endocrinol 4:1302–1310.CrossRefGoogle Scholar
  114. Forman BM, Samuels HH (1990): Interactions among a subfamily of nuclear hormone receptors. The regulatory zipper model. Mol Endocrinol 4:1293–1301.CrossRefGoogle Scholar
  115. Fowlkes DM, Mullis NT, Comeau CM, Crabtree GR (1984): Potential basis for regulation of the coordinately expressed fibrinogen genes: Homology in the 5′ flanking regions. Proc Natl Acad Sci USA 81:2313–2316.CrossRefGoogle Scholar
  116. Frain M, Hardon EM, Ciliberto G, Sala Trepat JM (1990): Binding of a liver-specific factor to the human albumin gene promoter and enhancer. Mol Cell Biol 10:991–999.Google Scholar
  117. Frain M, Swart G, Monaci P, Nicosia A, Stampfli S, Frank R, Cortese R (1989): The liver-specific transcription factor LF-B1 contains a highly diverged home-obox DNA binding domain. Cell 59:145–157.CrossRefGoogle Scholar
  118. Fraslin JM, Kneip B, Vaulont S, Glaise D, Munnich A, Guguen-Guilloze C (1985): Dependence of hepatocyte-specific gene expression on cell-cell interaction in primary culture. EMBO J 4:2487–2491.Google Scholar
  119. Friedman AD, McKnight SL (1990): Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene. Genes & Dev 4:1416–1426.CrossRefGoogle Scholar
  120. Friedman AD, Landschultz WH, McKnight SL (1989): CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells. Genes & Dev 3:1314–1322.CrossRefGoogle Scholar
  121. Fung WP, Thomas T, Dickson PW, Aldred AR, Milland J, Dziadek M, Power B, Hudson P, Schreiber (1988): Structure and expression of the rat transthyretin (prealbumin) gene. J Biol Chem 263:480–488.Google Scholar
  122. Fung W-P, Schreiber G (1987): Structure and expression of the genes for major acute phase α 1 -protein (thiostatin) and kininogene in the rat. J Biol Chem 262(19):2208–2308.Google Scholar
  123. Ganapathi MK, Schultz D, Mackiewicz A, Samols O, Ity S-I, Brabenec A, Macintyre SS, Kushner I (1988): Differential regulation of human serum amyloid A, C-reactive protein, and other acute phase proteins by cytokines in Hep 3B cells. J Immunol 141:564–569.Google Scholar
  124. Ganem D, Varmus HE (1987): The molecular biology of the hepatitis B viruses. Annu Rev Biochem 56:651–693.CrossRefGoogle Scholar
  125. Ganter U, Arcone R, Toniatti C, Morrone G, Ciliberto G (1989): Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J 8:3773–3779.Google Scholar
  126. Gauldie J, Richards C, Harnish D, Lansdorf P, Baumann H (1987): Interferon β2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci USA 84:7251–7255.CrossRefGoogle Scholar
  127. Gebhardt R (1990): Altered acinar distribution of glutamine synthetase and different growth response of cultured enzyme-positive and -negative hepatocytes after partial hepatectomy. Cancer Res 50:4407–4410.Google Scholar
  128. Geller SA, Nichols WS, Dycaico MJ, Felts KA, Sorge JA (1990): Histopathology of α 1-antitrypsin liver disease transgenic mouse model. Hepatology 12(I):40–47. Ghosh S, Baltimore D (1990): Activation in vitro of NF-kB by phosphorylation of its inhibitor IkB. Nature (Lond) 344:678–682.Google Scholar
  129. Ghosh S, Gifford AM, Riviere LR, Tempst P, Nolan GP, Baltimore D (1990): Cloning of the p50 DNA binding subunit of NF-kB: Homology to rel and dorsal Cell 62:1021–1029.CrossRefGoogle Scholar
  130. Gilmore TD, Temin HM (1986): Different localization of the product of the V-rel oncogene in chicken fibroblasts and spleen cells correlates with transformation by REV-T. Cell 44:791–800.CrossRefGoogle Scholar
  131. Gleiberman AS, Abelev GI (1985): Cell position and cell interactions: Expression of fetal phenotype of hepatocytes. Int Rev Cytol 95:229–266.CrossRefGoogle Scholar
  132. Gluecksohn-Waelsch S (1979): Genetic control of morphogenetic and biochemical differentiation: Lethal albino deletions in the mouse. Cell 16:225–237.CrossRefGoogle Scholar
  133. Gorski K, Carneiro M, Schibier U (1986): Tissue-specific in vitro transcription from the mouse albumin promoter. Cell 47:767–776.CrossRefGoogle Scholar
  134. Gourdeau H, Fournier REK (1990): Genetic analysis of mammalian cell differentiation. Annu Rev Cell Biol 6:69–94.CrossRefGoogle Scholar
  135. Grange T, Roux J, Rigaud G, Pictet R (1989): Two remote glucocorticoid responsive units interact cooperatively to promote glucocorticoid induction of rat tyrosine minotransferase gene expression. Nucleic Acids Res 17:8695–8709.CrossRefGoogle Scholar
  136. Grange T, Roux J, Rigaud G, Pictet R (1991): Cell-type-specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor. Nucleic Acids Res 19:131–139.CrossRefGoogle Scholar
  137. Granner DK, Beale EG (1985): Regulation of the synthesis of tyrosine aminotransferase and phosphoenolpyruvate carboxykinase by glucocorticoid hormones. In: Biochemical Actions of Hormones XII, Litwack G, ed., pp. 89–138. New York: Academic Press.Google Scholar
  138. Graves B, Johnson PF, McKnight SL (1986): Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene. Cell 44:565–576.CrossRefGoogle Scholar
  139. Grayson DR, Costa RH, Xanthopoulos KG, Darnell JE Jr (1988a): A cell-specific enhancer of the mouse α 1-antitrypsin gene has multiple functional regions and corresponding protein-binding sites. Mol Cell Biol 8:1055–1066.Google Scholar
  140. Grayson DR, Costa RH, Xanthopoulos KG, Darnell JE Jr (1988b): One factor recognizes the liver-specific enhancers in alpha-1-antitrypsin and transthyretin genes. Science 239:786–788.CrossRefGoogle Scholar
  141. Greengard O (1970): The developmental formation of enzymes in rat liver. In: Mechanism of Hormone Action J, Litwarck G ed., pp. 53–85. New York: Academic Press.Google Scholar
  142. Guertin M, Larue H, Bernier D, Wrange O, Chevrette M, Gingras M-C, Bélanger L (1988): Enhancer and promoter elements directing activation and glucocorticoid repression of the α-fetoprotein gene in hepatocytes. Mol Cell Biol 8:1398–1407.Google Scholar
  143. Guo W, Bell KD, Ou J-H (1991): Characterization of the hepatitis B virus Enhl enhancer and X promoter complex. J Virol 65:6686–6692.Google Scholar
  144. Hammer RE, Krumlauf R, Camper SA, Brinster RL, Tilghman S (1987): Diversity of a-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science 235:53–58.CrossRefGoogle Scholar
  145. Hanahan D (1989): Transgenic mice as probes into complex systems. Science 246:1265–1275.CrossRefGoogle Scholar
  146. Hardon EM, Frain M, Paonessa G, Cortese R (1988): Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO J 7:1711–1719.Google Scholar
  147. Hargrove JL, Granner DK (1985): Biosynthesis and intracellular processing of tyrosine aminotransferase. In: Transaminases, Christen P, Metzler PE, eds., pp. 511–532. New York: Wiley.Google Scholar
  148. Harrison SC (1991): A structural taxonomy of DNA-binding domains, Review article. Nature (Lond) 353:715–719.Google Scholar
  149. Haruna Y, Hayashi N, Katayama K, Yuki N, Kasahara A, Sasaki Y, Fusamoto H, Kamada T (1991): Expression of X protein and hepatitis B virus replication in chronic hepatitis. Hepatology 13(3):417–421.CrossRefGoogle Scholar
  150. Hashimoto S, Schmid W, Schuetz G (1984): Transcriptional activation of the rat liver tyrosine aminotransferase gene by cAMP. Proc Natl Acad Sci USA 81:6637–6641.CrossRefGoogle Scholar
  151. Hattori M, Abraham U, Northemann W, Fey GH (1990): Acute-phase reaction induces a specific complex between hepatic nuclear proteins and the interleukin 6 response element of the rat α 2-macroglobulin gene. Proc Natl Acad Sci 87:2364–2368.CrossRefGoogle Scholar
  152. Hatzoglou M, Lamers W, Bosch F, Wynshaw-Boris A, Clapp DW, Hanson RW (1990): Hepatic gene transfer in animals using retroviruses containing the promoter from the gene for phosphoenolpyruvate carboxykinase. J Biol Chem 265:17285–17293.Google Scholar
  153. Heard J-M, Herbomel P, Ott M-O, Mottura-Rollier A, Weiss M, Yaniv M (1987): Determinants of rat albumin promoter tissue specificity analyzed by an improved transient expression system. Mol Cell Biol 7:2425–2434.Google Scholar
  154. Held WA, Mullins JJ, Kuhn NJ, Gallagher JF, Gu GD, Gross KW (1989): T antigen expression and tumorigenesis in transgenic mice containing a mouse major urinary protein/SV40 T antigen hybrid gene. EMBO J 8:183–191.Google Scholar
  155. Herbomel P, Rollier A, Tronche F, Ott M-O, Yaniv M, Weiss M (1989): The rat albumin promoter is composed of six distinct positive elements within 130 nucleotides. Mol Cell Biol 9:4750–4758.Google Scholar
  156. Herrera R, Ro HS, Robinson GS, Xanthopoulos KG, Spiegelman BM (1989): A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation. Mol Cell Biol 9:5331–5339.Google Scholar
  157. Hirano T (1991): Interleukin 6 (IL-6) and its receptor: Their role in plasma cell neoplasias. Int J Cell Cloning 9:166–184.CrossRefGoogle Scholar
  158. Hocke GM, Barry D, Fey GH (1992): Synergistic action of interleukin-6 and glutocorticoids is mediated by the interleukin-6 response element of the rat α2 macroglobulin gene. Mol Cell Biol 12:2282–2294.Google Scholar
  159. Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991): p53 mutations in human cancer. Science 253:49–53.CrossRefGoogle Scholar
  160. Honigwachs J, Faktor O, Dikstein R, Shaul Y, Laub O (1989): Liver-specific expression of hepatitis B virus is determined by the combined action of the core gene promoter and the enhancer. J Virol 63:919–924.Google Scholar
  161. Hoodless PA, Roy RN, Ryan AK, Haché RJG, Vasa MZ, Deeley RG (1990): Developmental regulation of specific protein interactions with an enhancerlike binding site far upstream from the avian very-low-density apolipoprotein II gene. Mol Cell Biol 10:154–164.Google Scholar
  162. Hoofnagle JH, Shafritz DA, Popper H (1987): Chronic type B hepatitis and the “healthy” HBsAg carrier state. Hepatology 7:758–763.CrossRefGoogle Scholar
  163. Houssaint E (1980): Differentiation of the mouse hepatic primordium. I. An analysis of tissue interactions in hepatocyte differentiation. Cell Differ 9:269–279.CrossRefGoogle Scholar
  164. Howell BW, Lagacé M, Shore GC (1989): Activity of the carbamyl phosphate synthetase I promoter in liver nuclear extracts is dependent on a cis-acting C/EBP recognition element. Mol Cell Biol 9:2928–2933.Google Scholar
  165. Hsu IC, Metcalf RA, Sun T, Welsh JA, Wang NJ, Harris CC (1991): Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature (Lond) 350:427–428.CrossRefGoogle Scholar
  166. Hu K-Q, Siddiqui A (1991): Regulation of the hepatitis B virus gene expression by the enhancer element I. Virology 181:721–726.CrossRefGoogle Scholar
  167. Huang JH, Rienhoff HY Jr, Liao WSL (1990): Regulation of mouse serum amyloid A gene expression in transfected hepatoma cells. Mol Cell Biol 10(7):3619–3625.Google Scholar
  168. Huber P, Laurent M, Dalmon J (1990): Human β-fibrinogen gene expression. J Biol Chem 265(10):5695–5701.Google Scholar
  169. Hunter T (1991): Cooperation between oncogenes. Cell 64:249–270.CrossRefGoogle Scholar
  170. Imai E, Stromstedt P-E, Quinn PG, Carlstedt-Duke J, Gustafsson JA, Granner DK (1990): Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 10:4712–4719.Google Scholar
  171. Ingraham HA, Flynn SE, Voss JW, Albert VR, Kapilof MS, Wilson L, Rosenfeld MG (1990): The POU-specific domain of Pit-1 essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions. Cell 61:1021–1033.CrossRefGoogle Scholar
  172. Ip YT, Poon D, Stone D, Granner DK, Chalkley R (1990): Interaction of a liver-specific factor with an enhancer 4.8 kilobases upstream of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 10:3770–3781.Google Scholar
  173. Isshiki H, Akira S, Sugita T, Nishio Y, Hashimoto S, Pawlowski T, Suematsu S, Kishimoto T (1991): Reciprocal expression of NF-IL6 and C/EBP in hepato-cytes: Possible involvement of NF-IL6 in acute phase protein gene expression. New Biol 3:63–70.Google Scholar
  174. Ito K, Tanaka T, Tsutsumi R, Ishikawa K, Tsutsumi K-I (1990): Two different HNFl-like transcription activators in the liver bind to the same region of the rat aldolase B promoter. Biochem Biophys Res Commun 173:1337–1343.CrossRefGoogle Scholar
  175. Ito Y, Azrolan N, O’Connell A, Walsh A, Breslow JL (1990): Hypertriglyceridemia as a result of human Apo CIII gene expression in transgenic mice. Science 249:790–793.CrossRefGoogle Scholar
  176. Iyer SV, Davis DL, Seal SN, Burch JBE (1991): Chicken vitellogenin gene-binding protein, a leucine zipper transcription factor that binds to an important control element in the chicken vitellogenin II promoter, is related to rat DBP. Mol Cell Biol 11:4863–4875.Google Scholar
  177. Izban MG, Papaconstantinou J (1989): Cell-specific expression of mouse albumin promoter. J Biol Chem 264:9171–9179.Google Scholar
  178. Jallat S, Perraud F, Dalemans W, Bailan DA, Dieterce A, Faure T, Meulien P, Pavirani A (1990): Characterization of recombinant human factor IX expressed in transgenic mice and inderived trans-immortalized hepatic cell lines. EMBO J 9:3295–3301.Google Scholar
  179. Jefferson DM, Clayton DF, Darnell JE Jr, Reid LM (1984): Post-transcriptional modulation of gene expression in cultured rat hepatocytes. Mol Cell Biol 4:1929–1934.Google Scholar
  180. Johnson PF, Landschulz WH, Graves BJ, McKnight SL (1987): Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes & Dev 1:133–146.CrossRefGoogle Scholar
  181. Jones KW, Shapero MH, Chevrette M, Fournier REK (1991): Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A. Cell 66:861–872.CrossRefGoogle Scholar
  182. Jose-Estanyol M, Pollard A, Foiret D, Dana J-L (1989): A common liver-specific factor binds to the rat albumin and α-fetoprotein promoters in vitro and acts as a positive trans-acting factor in vivo. Eur J Biochem 181:761–766.CrossRefGoogle Scholar
  183. Jungermann K (1988): Metabolic zonation of liver parenchyma. Semin Liver Dis 8:329–341.CrossRefGoogle Scholar
  184. Kaling M, Kugler W, Ross K, Zoidl C, Ryffel GU (1991): Liver-specific gene expression: A-activator-binding site, a promoter module present in vitellogenin and acute-phase genes. Mol Cell Biol 11:93–101.Google Scholar
  185. Kageyama R, Sasai Y, Nakansihi S (1991): Molecular characterization of transcription factors that bind to the cAMP responsive region of the substance P precursor gene. J Biol Chem 266:15525–15531.Google Scholar
  186. Kaneda Y, Iwai K, Uchida T (1989): Increased expression of DNA controinduced with nuclear protein in adult rat liver. Science 243:375–378.CrossRefGoogle Scholar
  187. Kaneko S, Miller RH (1988): X-region-specific transcript in mammalian hepatitis B virus-infected liver. J Virol 62:3979–3984.Google Scholar
  188. Kardassis D, Hadzopoulou-Cladaras M, Ramji DP, Cortese R, Zannis VI, Cladaras C (1990a): Characterization of the promoter elements required for hepatic and intestinal transcription of the human apoB gene: Definition of the DNA-binding site of a tissue-specific transcriptional factor. Mol Cell Biol 10:2653–2659.Google Scholar
  189. Kardassis D, Zannis VI, Cladaras C (1990b): Purification and characterization of the nuclear factor BAL J Biol Chem 265:21733–21740.Google Scholar
  190. Karpen S, Banerjee R, Zelent A, Price P, Acs G (1988): Identification of protein-binding sites in the hepatitis B virus enhancer and core promoter domains. Mol Cell Biol 8:5159–5165.Google Scholar
  191. Kay MA, Baley P, Rothenberg S, Leland F, Fleming L, Parker Ponder K, Liu T-J, Finegod M, Darlington G, Pokorny W, Woo SLC (1992): Expression of human α-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes. Proc Natl Acad Sci USA 89:89–93.CrossRefGoogle Scholar
  192. Kekulé AS, Lauer U, Weiss L, Luber B, Hofschneider PH (1993): Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 361:742–745.CrossRefGoogle Scholar
  193. Kekulé AS, Lauer U, Meyer M, Caselman WH, Hofschneider PH, Koshy R (1990): The preS2/S region of integrated hepatitis B virus DNA encodes a transcriptional transactivator. Nature (Lond) 343:457–461.CrossRefGoogle Scholar
  194. Kern SE, Kinzler KW, Bruskin A, Jarosz D, Friedman P, Prives C, Vogelstein B (1991a): Identification of p53 as a sequence-specific DNA-binding protein. Science 252:1708–1711.CrossRefGoogle Scholar
  195. Kern SE, Kinzler KW, Baker SJ, Nigro JM, Rotter V, Levine AJ, Friedman P, Prives C, Vogelstein B (1991b): Mutant p53 proteins bind DNA abnormally in vitro. Oncogene 6:131–136.Google Scholar
  196. Kerr LD, Inoue J, Davis N, Link E, Baeuerle PA, Bose HR Jr, Verma IM (1991): The Rel-associated pp40 protein prevents DNA binding of Rel and Nf-/cB relationship with IkBβ and regulation by phosphorylation. Genes & Dev 5:1564–1576.Google Scholar
  197. Kieran M, Blank V, Logeat F, Vandekerckhove J, Lottspeich F, Le Bail O, Urban MB, Kourilsky P, Baeuerle PA, Israële A (1990): The DNA binding subunit of NF-kB and homologous to the rel oncogene product. Cell 62:1007–1018.CrossRefGoogle Scholar
  198. Killary AM, Fournier REK (1984): A genetic analysis of extinction: Trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell 38:523–534.CrossRefGoogle Scholar
  199. Kim C-M, Koike K, Saito I, Miyamura T, Jay G (1991): HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature (Lond) 351:317–320.CrossRefGoogle Scholar
  200. Kinoshita S, Akira S, Kishimoto T (1992): A member of the C/EBP family, NF-IL6β, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc Natl Acad Sci USA 89:1473–1476.CrossRefGoogle Scholar
  201. Klein ES, Di Lorenzo D, Posseckert G, Beato M, Ringold GM (1988): Sequences downstream of the glucocorticoid regulatory element mediate cyclohexunide inhibitron of steroid induced expression from the rat α 1 -acid glycoprotein promoter: Evidence for a labile transcription factor. Mol Endocrin 2:1343–1351.CrossRefGoogle Scholar
  202. Klein-Hitpass L, Ryffel GU, Heitlinger E, Cato ACB (1988): A 13-bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor. Nucleic Acids Res 16:647–663.CrossRefGoogle Scholar
  203. Klemm DJ, Roesler WJ, Liu J, Park EA, Hanson RW (1990): In vitro analysis of promoter elements regulating transcription of the phosphoenolpyruvate carboxylase (GTP) gene. Mol Cell Biol 10:480–485.Google Scholar
  204. Knowles BB, Howe CC, Aden DP (1980): Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209:497–499.CrossRefGoogle Scholar
  205. Kugler W, Wagner U, Ryffel GU (1988): Tissue-specificity of gene expression: A common liver-specific promoter element. Nucleic Acids Res 16:3165–3174.CrossRefGoogle Scholar
  206. Kugler W, Kaling M, Ross K, Wagner U, Ryffel GU (1990): BAP, a rat liver protein that activates transcription through a promoter element with similarity to the USF/MLTF binding site. Nucleic Acids Res 18:6943–6951.CrossRefGoogle Scholar
  207. Kunz D, Zimmermann R, Heisig M, Heinrich PC (1989): Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat α2 macroglobulin gene. Nucleic Acids Res 17:1121–1138.CrossRefGoogle Scholar
  208. Kuo CF, Xanthopoulos K, Darnell JE Jr (1990): Fetal and adult localization of C/EBP: Evidence for combinatorial action of transcription factors in cell-specific gene expression. Development 109:473–481.Google Scholar
  209. Kuo CJ, Mendel DB, Hansen LP, Crabtree GR (1991): Independent regulation of HNF-1 alpha and HNF-1 beta by retinoic acid in F9 teratocarcinoma cells. EMBO J 10:2231–2236.Google Scholar
  210. Kuo CJ, Conley PB, Chen L, Sladek FM, Darnell JE Jr, Crabtree GR (1992): A transcriptional hierarchi involved in mammalian cell-type specification. Nature (Lond) 355:457–460.CrossRefGoogle Scholar
  211. Ladias JAA, Karathanasis SK (1991): Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science 251:561–565.CrossRefGoogle Scholar
  212. Lai E, Darnell JE Jr (1991): Transcriptional control in hepatocytes: A window on development. Trends Biochem Sci 16:427–430.CrossRefGoogle Scholar
  213. Lai E, Prezioso VR, Smith E, Litvin O, Costa RH, Darnell JE Jr (1990): HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes & Dev 4:1427–1436.CrossRefGoogle Scholar
  214. Lai E, Prezioso VR, Tao WF, Chen WS, Darnell JE Jr (1991): Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes & Dev 5:416–427.CrossRefGoogle Scholar
  215. Lamb P, McKnight SL (1991): Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerization. Trends Biochem Sci 16:417–426.CrossRefGoogle Scholar
  216. Landschulz WH, Johnson PF, Adashi EY, Grave BJ, McKnight SL (1988): Isolation of a recombinant copy of the gene encoding C/EBP. Genes & Dev 2:786–800.CrossRefGoogle Scholar
  217. Lazzaro V, De Simone V, De Magistris L, Lehtonen E, Cortese R (1992): LFB-1 and LFB-3 homeoproteins are sequentially expressed during kidney development. Development 114:469–479.Google Scholar
  218. Le Douarin NM (1975): An experimental analysis of liver development. Med Biol 53:427–455.Google Scholar
  219. Ledley FD, Darlington GJ, Hahn T, Woo SLC (1987): Retroviral gene transfer into primary hepatocytes: Implications for genetic therapy of liver-specific functions. Proc Natl Acad Sci USA 84:5335–5339.CrossRefGoogle Scholar
  220. Lee G-H, Li H, Ohtake K, Nomura K, Hino O, Furuta Y, Aizawa S, Kitagawa T (1990): Detection of activated c-H-ras oncogene in hepatocellular carcinomas developing in transgenic mice harboring albumin promoter-regulated simian virus 40 gene. Carcinogenesis 11:1145–1148.CrossRefGoogle Scholar
  221. Lee T-H, Finegold MJ, Shen R-F, DeMayo JL, Woo SLC, Butel JS (1990): Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. J Virol 64:5939–5947.Google Scholar
  222. Leff T, Reue K, Melian A, Culver H, Breslow JL (1989): A regulatory element in the ApoCIII promoter that directs hepatic specific transcription binds to proteins in expressing and nonexpressing cell types. J Biol Chem 264:16132–16137.Google Scholar
  223. Leiting B, De Francesco R, Tomei L, Cortese R, Otting G, Wüthrich K (1993): The three-dimensional NMR-solution of the polypeptide fragment 195–268 of the LFB1/HNF1 transcription factor from rat liver comprises a non-classical homeodomain. EMBO J, in press.Google Scholar
  224. Lem J, Chin AC, Thayer MJ, Leach RJ, Fournier REK (1988): Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1. Proc Natl Acad Sci USA 85:7302–7306.CrossRefGoogle Scholar
  225. Lenardo MJ, Baltimore D (1989): NF-kB: A pleiotropic mediator of inducible and tissue-specific gene control. Cell 58:227–229.CrossRefGoogle Scholar
  226. Li X, Liao WS-L (1991): Expression of rat serum amyloid Al gene involves both C/EBP-like and NF-kB-like transcription factors. J Biol Chem 266:15192–15201.Google Scholar
  227. Li Y, Shen RF, Tsai SY, Woo SL (1988): Multiple hepatic transacting factors are required for in vitro transcription of the human alpha-1-antitrypsin gene. Mol Cell Biol 8:4362–4369.Google Scholar
  228. Lichtsteiner S, Schibler U (1989): A glycosylated liver-specific transcription factor stimulates transcription of the albumin gene. Cell 57:1179–1187.CrossRefGoogle Scholar
  229. Lichtsteiner S, Wuarin J, Schibler U (1987): The interplay of DNA-binding proteins on the promoter of the mouse albumin gene. Cell 51:963–973.CrossRefGoogle Scholar
  230. Lim MY, Davis N, Zhang J, Bose HR Jr (1990): The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70. Virology 175:149–160.CrossRefGoogle Scholar
  231. Liu JK, Di Persio CM, Zaret KS (1991): Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro. Mol Cell Biol 11:773–784.Google Scholar
  232. Löpez-Cabrera M, Letovsky J, Hu K-Q, Siddiqui A (1990): Multiple liver-specific factors bind to the hepatitis B virus core/pregenomic promoter: Trans-activation and repression by CCAAT/enhancer binding protein. Proc Natl Acad Sci USA 87:5069–5073.CrossRefGoogle Scholar
  233. Löpez-Cabrera M, Letovsky J, Hu K-Q, Siddiqui A (1991): Transcriptional factor C/EBP binds to and transactivates the enhancer element II of the hepatitis B virus. Virology 183:825–829.CrossRefGoogle Scholar
  234. Lowell CA, Potter DA, Stearman RS, Morrow JF (1986): Structure of the murine serum amyloid A gene family. J Biol Chem 261:8442–8452.Google Scholar
  235. Lucas PC, O’Brien RM, Mitchell JA, Davis CM, Imai E, Forman BM, Samuels HH, Granner DK (1991): A retinoic acid response element is part of a pleiotropic domain in the phosphoenolpyruvate carboxykinase gene. Proc Natl Acad Sci USA 88:2184–2188.CrossRefGoogle Scholar
  236. Lucero MA, Sanchez D, Ochoa AR, Brunei F, Cohen GN, Baralle FE, Zakin MM (1989): Interaction of DNA-binding protein with the tissue-specific human apolipoprotein-AII enhancer. Nucleic Acids Res 17:2283–2300.CrossRefGoogle Scholar
  237. Maguire HE, Hoeffler JP, Siddiqui A (1991): HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-promoter interactions. Science 252:842–844.CrossRefGoogle Scholar
  238. Maire P, Wuarin J, Schibler U (1989): The role of cis-acting promoter elements in tissue-specific albumin gene expression. Science 244:343–346.CrossRefGoogle Scholar
  239. Majello B, Arcone R, Toniatti C, Ciliberto G (1990): Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J 9:457–465.Google Scholar
  240. Marinkovic’ S, Baumann H (1990): Structure, hormonal regulation and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene. Mol Cell Biol 10:1573–1583.Google Scholar
  241. Martinez E, Wahli W (1989): Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity. EMBO J 8:3781–3791.Google Scholar
  242. Mendel DB, Hansen LP, Graves MK, Conley PB, Crabtree GR (1991a): HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and horneo domains, but not activation domains, and form heterodimers in vitro. Genes & Dev 5(6): 1042–1056.CrossRefGoogle Scholar
  243. Mendel DB, Khavari PA, Conley PB, Graves MK, Hansen LP, Admon A, Crabtree GR (1991b): Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. Science 254:1762–1767.CrossRefGoogle Scholar
  244. Mendelzon D, Boissier F, Zakin MM (1990): The binding site for the liver-specific transcription factor Tf-LFl and the TATA box of the human transferrin gene promoter are the only elements necessary to direct liver-specific transcription in vitro. Nucleic Acids Res 18:5717–5721.CrossRefGoogle Scholar
  245. Mermod N, O’Neill EA, Kelly TJ, Tjian R (1989): The proline-rich transcriptional activator of CTF/NF-1 is distinct from the replication and DNA binding domain. Cell 58:741–753.CrossRefGoogle Scholar
  246. Metz R, Ziff E (1991): cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription. Genes &Dev 5:1754–1766.CrossRefGoogle Scholar
  247. Metzger S, Leff T, Breslow JL (1990): Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and modulate its transcriptional activity in hepatic cells. J Biol Chem 265:9978–9983.Google Scholar
  248. Mirkovitch J, Darnell JE Jr (1991): Rapid in vivo footprinting technique identifies proteins bound to the TTR gene in the mouse liver. Genes & Dev 5:83–93.CrossRefGoogle Scholar
  249. Molitor JA, Walker WH, Doerre S, Ballard DW, Greene WC (1990): NF-kB: A family of inducible and differentially expressed enhancer-binding proteins in human T cells. Proc Natl Acad Sci USA 87:10028–10032.CrossRefGoogle Scholar
  250. Monaci P, Nicosia A, Cortese R (1988): Two different liver-specific factors stimulate in vitro transcription from the human α 1-antitrypsin promoter. EMBO J 7:2075–2087.Google Scholar
  251. Morrison LE, Kabrun N, Mudri S, Hayman MJ, Enrielto PJ (1989): Viral rel and cellular rel associated with oncogene proteins in transformed and normal cells. Oncogene Res 4:677–683.Google Scholar
  252. Morrone G, Cortese R, Sorrentino V (1989): Post-transcriptional control of negative acute phase genes by transforming growth factor beta. EMBO J 8:3764–3771.Google Scholar
  253. Morrone G, Ciliberto G, Oliviero S, Arcone R, Dente L, Content J, Cortese R (1988): Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J Biol Chem 263:12554–12558.Google Scholar
  254. Möröy T, Marchio A, Etiemble J, Trépo C, Tiollais P, Buendia M-A (1986): Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks. Nature (Lond) 324:276–279.CrossRefGoogle Scholar
  255. Mueller CR, Maire P, Schibier U (1990): DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined post-transcriptionally. Cell 61:279–291.CrossRefGoogle Scholar
  256. Nakabayashi H, Watanabe K, Saito A, Otsuru A, Sawadaishi K, Tamaoki T (1989): Transcriptional regulation of α-fetoprotein expression by dexametha-sone in human hepatoma cells. J Biol Chem 261:266–271.Google Scholar
  257. Nakao K, Lawless L, Ohe Y, Miyao Y, Nakabayashi H, Kamiya H, Miura K, Ohtsuka E, Tamaoki T (1990): c-Ha-ras down regulates the a-fetoprotein gene but not the albumin gene in human hepatoma cells. Mol Cell Biol 10:1461–1469.Google Scholar
  258. Nicosia A, Monaci P, Tomei L, De Francesco R, Nuzzo M, Stunnenberg H, Cortese R (1990): A myosin-like dimerization helix and an extra-large home-odomain are essential elements of the tripartite DNA binding structure of LFB1. Cell 61:1225–1236.CrossRefGoogle Scholar
  259. Nitsch D, Stewart AF, Boshart M, Mestril R, Weih F, Schuetz G (1990): Chromatin structures of the rat aminotransferase gene relate to the function of its cis-acting elements. Mol Cell Biol 10:3334–3342.Google Scholar
  260. Nolan GP, Ghosh S, Liou H-C, Tempst P, Baltimore D (1991): DNA binding and IkB inhibition of the cloned p65 subunit of NF-kB, a rel-related polypeptide. Cell 64:961–969.CrossRefGoogle Scholar
  261. Ochoa A, Brunei F, Mendelzon D, Cohen GN, Zakin MM (1989): Different liver nuclear proteins bind to similar DNA sequences in the 5′ flanking regions of three hepatic genes. Nucleic Acids Res 17:119–133.CrossRefGoogle Scholar
  262. Ogami K, Hadzopoulou-Cladaras M, Zannis VI (1990): Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene. J Biol Chem 265:9808–9815.Google Scholar
  263. Ogami K, Kardassis D, Cladaras C, Zannis VI (1991): Purification and characterization of a heat-stable nuclear factor CIIIB1 involved in the regulation of the human ApoC-III gene. J Biol Chem 266:9640–9646.Google Scholar
  264. Oliviero S, Cortese R (1989): The human haptoglobin gene promoter: Interleu-kin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. EMBO J 8:1145–1151.Google Scholar
  265. Oliviero S, Morrone G, Cortese R (1987): The human haptoglobin gene: Transcriptional regulation during development and acute phase induction. EMBO 7 6:1905–1912.Google Scholar
  266. O’Rourke RW, Miller CW, Kato GJ, Simon KJ, Chen D-L, Dang C-V, Koeffler HP (1990): A potential transcriptional activation element in the p53 protein. Oncogene 5:1829–1832.Google Scholar
  267. Pajk Y-K, Chang DJ, Reardon CA, Walker MD, Taxman E, Taylor JM (1988): Identification and characterization of transcriptional regulatory regions associated with expression of the human apolipoprotein E gene. J Biol Chem 263:13340–13349.Google Scholar
  268. Paonessa G, Gounari F, Frank R, Cortese R (1988): Purification of a NFl-like DNA-binding protein from rat liver and cloning of the corresponding cDNA. EMBO J 7:315–3123.Google Scholar
  269. Papazafiri P, Ogami K, Ramji DP, Nicosia A, Monaci P, Cladaras C, Zannis VI (1991): Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites. J Biol Chem 266:5790–5797.Google Scholar
  270. Park EA, Roesler WJ, Liu J, Klemm DJ, Gurney AL, Thatcher JD, Schuman J, Friedman A, Hanson RW (1990): The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP). Mol Cell Biol 10:6264–6272.Google Scholar
  271. Parker Ponder K, Gupta S, Leland F, Darlington G, Finegold M, DeMayo J, Ledley FD, Chowdhury JR, Woo SLC (1991): Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc Natl Acad Sci USA 88:1217–1221.CrossRefGoogle Scholar
  272. Pastore A, De Francesco R, Barbato G, Castiglione Morelli MA, Motta A, Cortese R (1991): 1H resonance assignment and secondary structure determination of the dimerization domain of transcription factor LFB1. Biochemistry 30(1): 148–153.CrossRefGoogle Scholar
  273. Patel NU, Jameel S, Isom H, Siddiqui A (1989): Interactions between nuclear factors and the hepatitis B virus enhancer. J Virol 63:5293–5301.Google Scholar
  274. Paul D, Hohne M, Pinkert C, Piasecki A, Ummelmann E, Brinster RL (1988): Immortalized differentiated hepatocyte lines derived from transgenic mice harboring SV40 T-antigen genes. Exp Cell Res 175:354–362.CrossRefGoogle Scholar
  275. Pawlak A, Bryans M, Jost J-P (1990): An avian 40-KDa nucleoprotein binds preferentially to a promoter sequence containing one single pair of methylated CpG. Nucleic Acids Res 19:1029–1034.CrossRefGoogle Scholar
  276. Pei D, Shih C (1991): An “attenuator domain” is sandwiched by two distinct transactivation domains in the transcription factor C/EBP. Mol Cell Biol 11:1480–1487.Google Scholar
  277. Pei D, Shih C (1990): Transcriptional activation and repression by cellular DNA-binding protein C/EBP. J Virol 64:1517–1522.Google Scholar
  278. Peng H, Armentano D, MacKenzie-Graham L, Shen R-F, Darlington G, Ledley FD, Woo SLC (1988): Retroviral-mediated gene transfer and expression of human phenylalanine hydroxylase in primary mouse hepatocytes. Proc Natl Acad Sci USA 85:8146–8150.CrossRefGoogle Scholar
  279. Perlmutter DH (1991): The cellular basis for liver injury in α 1-antitrypsin deficiency. Hepatology 13(1): 172–185.CrossRefGoogle Scholar
  280. Perlmutter DH, Dinarello CA, Punsal PJ, Colten HR (1986): Cathetin/tumor necrosis factor regulates hepatic acute-phase gene expression. J Clin Invest 78:1349–1354.CrossRefGoogle Scholar
  281. Petersen DD, Magnuson MA, Granner DK (1988): Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 8:96–104.Google Scholar
  282. Petit C, Levilliers J, Ott MO, Weiss MC (1986): Tissue-specific expression of the rat albumin gene: Genetic control of its extinction in microcell hybrids. Proc Natl Acad Sci USA 83:2561–2565.CrossRefGoogle Scholar
  283. Philipsen JNJ, Hennis BC, Ab G (1988): In vivo footprinting of the estrogen-inducible vitellogenin II gene from chicken. Nucleic Acids Res 16:9663–9676.CrossRefGoogle Scholar
  284. Pinkert CA, Ornitz DM, Brinster RL, Palmiter RD (1987): An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes & Dev 1:268–276.CrossRefGoogle Scholar
  285. Poli V, Cortese R (1989): Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. Proc Natl Acad Sci USA 86:8202–8206.CrossRefGoogle Scholar
  286. Poli V, Mancini FP, Cortese R (1990): IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 63:643–653.CrossRefGoogle Scholar
  287. Poli V, Silengo L, Altruda F, Cortese R (1989): The analysis of the human hemopexin promoter defines a new class of liver-specific genes. Nucleic Acids Res 17:9351–9365.Google Scholar
  288. Popper H, Shafritz DA, Hoofnagle JH (1987): Relation of the hepatitis B virus carrier state to hepatocellular carcinoma. Hepatology 7:764–772.CrossRefGoogle Scholar
  289. Prowse KR, Baumann H (1988): Hepatocyte-stimulating factor, β 2 interferon and interleukin-1 enhance expression of the rat α 1 -acid glycoprotein gene via a distal upstream regulatory region. Mol Cell Biol 8:42–51.Google Scholar
  290. Putnam FW (1975): The Plasma Proteins: Structure, Function and Genetic Control. New York: Academic Press.Google Scholar
  291. Quinn PG, Granner DK (1990): Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element. Mol Cell Biol 10:3347–3364.Google Scholar
  292. Quinn PG, Wong TW, Magnuson MA, Shabb JB, Granner DK (1988): Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 8:3467–3475.Google Scholar
  293. Quistorff B (1990): Metabolic heterogeneity of liver parenchymal cells. Essays Biochem 25:83–136.Google Scholar
  294. Ramadori G, Sipe JD, Dinarello CA, Mitzel SB, Colten HR (1985): Pretransla-tional modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. I. Exp Med 162:930–942.CrossRefGoogle Scholar
  295. Ramji DP, Tadros MH, Hardon EM, Cortese R (1991): The transcription factor LF-A1 interacts with a bipartite recognition sequence in the promoter regions of several liver-specific genes. Nucleic Acids Res 19:1139–1146.CrossRefGoogle Scholar
  296. Ramji DP, Vitelli A, Tronche F, Cortese R, Ciliberto G (1993): The two C/EBP isoforms, IL-6 DBP/NF-IL6 and C/EBP6/NF-IL6β are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucl Acids Res 21:289–294.CrossRefGoogle Scholar
  297. Ramji DP, Tronche F, Gallinari P, Vitelli A, Ciliberto G, Cortese R (1992): Induetion of gene transcription by interleukin-6 (IL-6) requires post-translational modification of IL-6 DBP. In: IL-6: Physiopathology and Clinical Potentials, Revel M, ed., pp. 55–62. Raven Press.Google Scholar
  298. Raney AK, Milich DR, McLachlan A (1989): Characterization of hepatitis B virus major surface antigen gene transcriptional regulatory elements in differentiated hepatoma cell lines. J Virol 63:3919–3925.Google Scholar
  299. Raney AK, Easton AJ, Milich DR, McLachlan A (1991): Promoter-specific trans-activation of hepatitis B virus transcription by a glutamine- and proline-rich domain of hepatocyte nuclear factor 1. J Virol 65:5774–5781.Google Scholar
  300. Raney AK, Milich DR, Easton AJ, McLachlan A (1990): Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines. J Virol 64:2360–2368.Google Scholar
  301. Rangan VS, Das GC (1990): Purification and biochemical characterization of hepatocyte nuclear factor 2 involved in liver-specific transcription of the human alpha 1-antitrypsin gene. J Biol Chem 265:8874–8879.Google Scholar
  302. Raycroft L, Wu H, Lozano G (1990): Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science 249:1049–1051.CrossRefGoogle Scholar
  303. Raycroft L, Schmidt JR, Yoas K, Hao M, Lozano G (1991): Analysis of p53 mutants for transcriptional activity. Mol Cell Biol 11:6067–6074.Google Scholar
  304. Raymondjean M, Cereghini S, Yaniv M (1988): Several distinct “CCAAT” box binding proteins coexist in eukaryotic cells. Proc Natl Acad Sci USA 85:757–761.CrossRefGoogle Scholar
  305. Raymondjean M, Pichard A-L, Gregori C, Ginot F, Kahn A (1991): Interplay of an original combination of factors: C/EBP, NFY, HNF3, and HNF1 in the rat aldolase B gene promoter. Nucleic Acids Res 19:6145–6153.CrossRefGoogle Scholar
  306. Reik A, Schuetz G, Stewart AF (1991): Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: Induction leads to a reversible disruption of nucleosomes over an enhancer. EMBO J 10:2569–2576.Google Scholar
  307. Reue K, Leff T, Breslow JL (1988): Human apolipoprotein Oil gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors. J Biol Chem 263:6857–6864.Google Scholar
  308. Rey-Campos J, Chouard T, Yaniv M, Cereghini S (1991): vHNFl is a homeopro-tein that activates transcription and forms heterodimers with HNF-1. EMBO J 10(6):1445–1457.Google Scholar
  309. Rigaud G, Roux J, Pictet R, Grange T (1991): In vivo footprinting of rat TAT gene: Dynamic interplay between the glucocorticoid receptor and a liver-specific factor. Cell 67:977–986.CrossRefGoogle Scholar
  310. Ro HS, Roncari DA (1991): The C/EBP-binding region and adjacent sites regulate expression of the adipose P2 gene in human preadipocytes. Mol Cell Biol 11:2303–2306.Google Scholar
  311. Roesler WJ, Vandenbark GR, Hanson RW (1989): Identification of multiple protein binding domains in the promoter-regulatory region of the phospho-enolpyruvate carboxykinase (GTP) gene. J Biol Chem 264:9657–9664.Google Scholar
  312. Roman C, Platero JS, Shuman J, Calame K (1990): Ig/EBP-1: A ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes & Dev 4:1404–1415.CrossRefGoogle Scholar
  313. Ron D, Habener JF (1992): CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes & Dev 6:439–453.CrossRefGoogle Scholar
  314. Ron D, Brasier AR, Wright KA, Habener JF (1990): The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers. Mol Cell Biol 10:4389–4395.Google Scholar
  315. Ross RS, Li AC, Hoeg JM, Schumacher UK, Demosky SJ Jr, Brewer HB Jr (1991): Apolipoprotein B upstream suppressor site: Identification of an element which can decrease apolipoprotein B transcription. Biochem Biophys Res Commun 176:1116–1122.CrossRefGoogle Scholar
  316. Roth S, Stein D, Nüsslein-Volhard C (1989): A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo. Cell 59:1189–1202.CrossRefGoogle Scholar
  317. Rottman JN, Widom RL, Nadal-Ginard B, Mahdavi V, Karathanasis SK (1991): A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways. Mol Cell Biol 11:3814–3820.Google Scholar
  318. Rubin EM, Ishida BY, Clift SM, Krauss RM (1991): Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two new high density lipoprotein size subclasses. Proc Natl Acad Sci USA 88:434–438.CrossRefGoogle Scholar
  319. Ruiz-Bravo N, Ernest MJ (1982): Induction of tyrosine aminotransferase mRNA by glucocorticoids and cAMP in fetal rat liver. Proc Natl Acad Sci USA 79:365–368.CrossRefGoogle Scholar
  320. Ruppert S, Kelsey G, Scedl A, Schmid E, Thies E, Schutz G (1992): Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice. Genes & Dev 6:1430–1443.CrossRefGoogle Scholar
  321. Ruppert S, Boshart M, Bosch FX, Schmid W, Fournier REK, Schuetz G (1990): Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes. Cell 61:895–904.CrossRefGoogle Scholar
  322. Rushlow CA, Han K, Manley JL, Levine M (1989): The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila, Cell 59:1165–1177.CrossRefGoogle Scholar
  323. Rüther U, Woodroofe C, Fattori E, Ciliberto G (1993): Inducible formation of liver tumors in transgenic mice. Oncogene 8:87–93.Google Scholar
  324. Rüther U, Tripodi M, Cortese R, Wagner E (1987): The expression of the human alpha-1-antitrypsin gene in transgenic mice. Nucleic Acids Res 15:7519–7529.CrossRefGoogle Scholar
  325. Samuelsson L, Strömberg K, Vikman K, Bjursell G, Enerbäck S (1991): The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. EMBO J 10:3787–3793.Google Scholar
  326. Sandgren EP, Quaife CJ, Pinkert CA, Palmiter RD, Brinster RL (1989): Onco-gene-induced liver neoplasia in transgenic mice. Oncogene 4:715–724.Google Scholar
  327. Sawadaishi K, Morinaga T, Tamaoki T (1988): Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human α-fetopro-tein and albumin genes. Mol Cell Biol 8:5179–5187.Google Scholar
  328. Schmid E, Schmid W, Mayer D, Jastorff B, Schuetz G (1987): Transcriptional activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes. Eur J Biochem 165:499–506.CrossRefGoogle Scholar
  329. Schneider JA, Weiss MC (1971): Expression of differentiated functions in hepatoma cell hybrids. I. Tyrosine aminotransferase in hepatoma-fibroblast hybrids. Proc Natl Acad Sci USA 68:127–131.CrossRefGoogle Scholar
  330. Seal SN, Davis DL, Burch JBE (1991): Mutational studies reveal a complex set of positive and negative control elements within the chicken vitellogenin II promoter. Mol Cell Biol 11:2704–2717.Google Scholar
  331. Sen R, Baltimore D (1986): Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705–716.CrossRefGoogle Scholar
  332. Sepulveda AR, Finegold MJ, Smith B, Slagle BL, DeMayo JL, Shen R-F, Woo SLC, Butel JS (1989): Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human α-antitrypsin gene. Cancer Res 49:6108–6117.Google Scholar
  333. Seto E, Mitchell PJ, Yen TSB (1990): Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature (Lond) 344:72–74.CrossRefGoogle Scholar
  334. Shaul Y, Rutter WJ, Laub O (1985): A human hepatitis B viral enhancer element. EMBO J 4:427–430.Google Scholar
  335. Shen R-F, Li Y, Sifers RN, Wang HH, Jardick C, Tsai SY, Woo SLC (1987): Tissue-specific expression of the human α 1 -antitrypsin gene is controlled by multiple cis-regulatory elements. Nucleic Acids Res 15:8399–8415.CrossRefGoogle Scholar
  336. Shimada T, Noda T, Tashiro M, Murakami T, Takiguchi M, Mori M, Yamamura K-I, Saheki T (1991): Correction of ornithine transcarbamylase (OTC) deficiency in spfash mice by introduction of rat OTC gene. FEBS Lett 279:198–200.CrossRefGoogle Scholar
  337. Shirakata Y, Kawada M, Fujkik Y, Sano H, Oda M, Yaginuma K, Kobayashi M, Koike K (1989): The X gene of hepatitis B viras induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells. Jpn J Cancer Res 80:617–621.CrossRefGoogle Scholar
  338. Shoshani T, Benvenisty N, Tras M, Reshef L (1991): cis-Regulatory elements that confer differential expression upon the rat gene encoding phosphoenolpyru-vate carboxykinase in kidney and liver. Gene 101:279–283.CrossRefGoogle Scholar
  339. Siddiqui A, Jameel S, Mapoles J (1987): Expression of the hepatitis B virus X gene in mammalian cells. Proc Natl Acad Sci USA 84:2513–2517.CrossRefGoogle Scholar
  340. Siddiqui A, Gaynor R, Srinivasan A, Mapoles J, Farr RW (1989): taws-Activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein. Virology 169:479–484.CrossRefGoogle Scholar
  341. Sifers RN, Finegold MJ, Woo SLC (1989): Alpha-1-antitrypsin deficiency: Accumulation or degradation of mutant variants within the hepatic endoplasmic reticulum. Am J Respir Cell Mol Biol 1:341–345.Google Scholar
  342. Simek S, Rice NR (1988): p59 v-rel, The transforming protein of reticuloen-dotheliosis virus, is complexed with at least four other proteins in transformed chicken lymphoid cells. J Virol 62:4730–4736.Google Scholar
  343. Sladek FM, Zhong WM, Lai E, Darnell JE Jr (1990): Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes & Dev 4:2353–2365.CrossRefGoogle Scholar
  344. Slagle BL, Zhou Y-Z, Butel JS (1991): Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas. Cancer Res 51:49–54.Google Scholar
  345. Spandau DF, Lee C-H (1988): trans-Activation of viral enhancers by the hepatitis B virus X protein. J Virol 62(2):427–434.Google Scholar
  346. Thayer MJ, Fournier REK (1989): Hormonal regulation of TSE-1 repressed genes: Evidence for multiple genetic controls in extinction. Mol Cell Biol 9:2837–2846.Google Scholar
  347. Theiler (1989): The House Mouse. New York: Springer-Verlag.Google Scholar
  348. Theill LE, Castrillo JL, Wu D, Karin M (1989): Dissection of functional domains of the pituitary-specific transcription factor GHF-1. Nature (Lond) 342:945–948.CrossRefGoogle Scholar
  349. Tian J-M, Schibler U (1991): Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4. Genes & Dev 5:2225–2234.CrossRefGoogle Scholar
  350. Tiollais P, Pourcel C, Dejean A (1985): The hepatitis B virus. Nature (Lond) 317:489–495.CrossRefGoogle Scholar
  351. Tognoni A, Cattaneo R, Serfling E, Schaffner W (1985): A novel expression selection approach allows precise mapping of the hepatitis B virus enhancer. Nucleic Acids Res 13:7457–7464.CrossRefGoogle Scholar
  352. Tomei L, Piaggio G, Toniatti C, De Francesco R, Gerstner J, Cortese R (1993): LFB1/HNF1 Acts as repressor of its own transcription. Submitted.Google Scholar
  353. Tomei L, Cortese R, De Francesco R (1992): A POU-A related region dictates DNA binding specificity of LFB1/HNF1 by orienting the two XL-homeodomains in the dimer. EMBO J 11:4119–4129.Google Scholar
  354. Toniatti C, Monaci P, Nicosia A, Cortese R, Ciliberto G (1993): A bipartite activation domian is responsible for the activity of transcription factor HNF1/LFB1 in cells of hepatic and non-hepatic origin. DNA and Cell Biol, in press.Google Scholar
  355. Toniatti C, Monaci P, Nicosia A, Cortese R, Ciliberto G: A bipartite transactivation domain in transcriptional activator LFBl/HNF-1α functions in cells of non-hepatic origin (in manuscript).Google Scholar
  356. Toniatti C, Arcone R, Majello B, Ganter U, Arpaia G, Ciliberto G (1990a): Regulation of the human C-reactive protein gene, a major marker of inflammation and cancer. Mol Biol Med 7:199–212.Google Scholar
  357. Toniatti C, Demartis A, Monaci P, Nicosia A, Ciliberto G (1990b): Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites. EMBO J 9:4467–4475.Google Scholar
  358. Tripodi M, Abbott C, Vivian N, Cortese R, Lovell-Badge R (1991): Disruption of the LF-A1 and LF-B1 binding sites in the human alpha-1-antitrypsin gene has a differential effect during development in transgenic mice. EMBO J 10:3177–3182.Google Scholar
  359. Tronche F, Rollier A, Bach I, Weiss MC, Yaniv M (1989): The rat albumin promoter: Cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation. Mol Cell Biol 9:4759–4766.Google Scholar
  360. Tronche F, Rollier A, Herbomel P, Bach I, Cereghini S, Weiss M, Yaniv M (1990): Anatomy of the rat albumin promoter. Mol Biol Med 7:173–185.Google Scholar
  361. Trujillo MA, Letovsky J, Maguire HF, Lopez-Cabrera M, Siddiqui A (1991): Functional analysis of a liver-specific enhancer of the hepatitis B virus. Proc Natl Acad Sci USA 88:3797–3801.CrossRefGoogle Scholar
  362. Trus M, Benvenisty N, Cohen H, Reshef L (1990): Developmentally regulated interactions of liver nuclear factors with the rat phosphoenolpyruvate car-boxykinase promoter. Mol Cell Biol 10:2418–2422.Google Scholar
  363. Tsutsumi K-I, Ito K, Ishikawa K (1989): Developmental appearance of transcription factors that regulate liver-specific expression of the aldolase B gene. Mol Cell Biol 9:4923–931.Google Scholar
  364. Tung HYL, Bargmann WJ, Lim M-Y, Bose HR Jr (1988): The v-rel oncogene product is complexed to a 40-kDa phosphoprotein in transformed lymphoid cells. Proc Natl Acad Sci USA 85:2479–2483.CrossRefGoogle Scholar
  365. Tur-Kaspa R, Burk RD, Shaul Y, Shafritz DA (1986): Hepatitis B virus DNA contains a glucocorticoid-responsive element. Proc Natl Acad Sci USA 83:1627–1631.CrossRefGoogle Scholar
  366. Tur-Kaspa R, Shaul Y, Moore DD, Burk RD, Okret S, Poellinger R, Shafritz DA (1988): The glucocorticoid receptor recognizes a specific nucleotide sequence in hepatitis B virus DNA causing increased activity of the HBV enhancer. Virology 167:630–633.Google Scholar
  367. Twu JS, Robinson WS (1989): Hepatitis B virus X gene can transactivate heterologous viral sequences. Proc Natl Acad Sci USA 86:2046–2050.CrossRefGoogle Scholar
  368. Twu JS, Schloemer RH (1987): Transcriptional trans-activating function of hepatitis B virus. J Virol 61(11):3448–3453.Google Scholar
  369. Twu JS, Chu K, Robinson WS (1989): Hepatitis B virus X gene activates kB-like enhancer sequences in the long terminal repeat of human immunodeficiency virus 1. Proc Natl Acad Sci USA 86:5168–5172.CrossRefGoogle Scholar
  370. Umek RM, Friedman AD, McKnight SL (1991): CCAAT-enhancer binding protein: A component of a differentiation switch. Science 251:288–293.CrossRefGoogle Scholar
  371. Vaccaro M, Pawlak A, Jost J-P (1990): Positive and negative regulatory elements of chicken vitellogenin II gene characterized by in vitro transcription competition assays in a homologous system. Proc Nail Acad Sci USA 87:3047–3051.CrossRefGoogle Scholar
  372. Van Snick J (1990): Interleukin-6: An overview. Annu Rev Immunol 8:253–278.CrossRefGoogle Scholar
  373. Vaulont S, Puzenat N, Kahn A, Raymondjean M (1989a): Analysis by cell-free transcription of the liver-specific pyruvate kinase gene promoter. Mol Cell Biol 9:4409–4415.Google Scholar
  374. Vaulont S, Puzenat N, Leyrat F, Cognet M, Kahn A, Raymondjean M (1989b): Proteins binding to the liver-specific pyruvate kinase gene promoter. A unique combination of known factors. J Mol Biol 209:205–219.CrossRefGoogle Scholar
  375. Verrijzer CP, Kal A-J, van der Vliet PC (1990): The oct-1 horneo domain contacts only part of the octamer sequence and full oct-1 DNA-binding activity requires the POU-specific domain. Genes & Dev 4:1964–1974.CrossRefGoogle Scholar
  376. Walsh A, Ito Y, Breslow JL (1989): High levels of human A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3. J Biol Chem 264:6488–6494.Google Scholar
  377. Wang Y, Chen P, Wu X, Sun A-L, Wang H, Zhu Y-A, Li Z-P (1990): A new enhancer element, ENII, identified in the X gene of hepatitis B virus. J Virol 64:3977–3981.Google Scholar
  378. Weigel D, Jäckie H (1990): Forkhead: A new eukaryotic DNA binding motif? Cell 63:455–456.CrossRefGoogle Scholar
  379. Weih F, Stewart AF, Boshart M, Nitsch D, Schuetz G (1990): In vivo monitoring of a cAMP-stimulated DNA-binding activity. Genes & Dev 4:1437–1449.CrossRefGoogle Scholar
  380. Widom RL, Ladias JAA, Kouidou S, Karathanasis SK (1991): Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells. Mol Cell Biol 11:677–687.Google Scholar
  381. Wijnholds J, Muller E, Ab G (1991): Oestrogen facilitates the binding of ubiquitous and liver-enriched nuclear proteins to the apoVLDL II promoter in vivo. Nucleic Acids Res 19:33–41.CrossRefGoogle Scholar
  382. Wijnholds, J, Philipsen JNF, Ab G (1988): Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apolVLDL II promoter in vivo. EMBO J 7:2757–2763.Google Scholar
  383. Williams PM, Ratajczak T, Lee SC, Ringold GM (1991): AGP/EBP (LAP) expressed in rat hepatoma cells interacts with multiple promoter sites and is necessary for maximal glucocorticoid induction of the rat alpha-1 acid glycoprotein gene. Mol Cell Biol 11:4959–4965.Google Scholar
  384. Williams SC, Cantwell CA, Johnson PF (1991): A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes & Dev 5:1553–1567.CrossRefGoogle Scholar
  385. Wilson DR, Juan TSC, Wilde MD, Fey GH, Darlington GJ (1990): A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6. Mol Cell Biol 10:6181–6191.Google Scholar
  386. Wilson JM, Johnston DE, Jefferson DM, Mulligan RC (1988): Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 85:4421–4425.CrossRefGoogle Scholar
  387. Wilson JM, Chowdhury NR, Grossman M, Wajsman R, Epstein A, Mulligan RC, Chowdhury JR (1990): Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes. Proc Natl Acad Sci USA 87:8437–8441.CrossRefGoogle Scholar
  388. Wolff JA, Yee J-K, Skelly HF, Moores JC, Respess JG, Friedmann T, Leffert H (1987): Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes. Proc Natl Acad Sci USA 84:3344–3348.CrossRefGoogle Scholar
  389. Wollersheim M, Debelka U, Hoschneider PH (1988): A transactivating function encoded in the hepatitis B virus X gene is conserved in the integrated state. Oncogene 3(5):545–552.Google Scholar
  390. Won K-A, Baumann H (1991): NF-AB, a liver-specific and cytokine-inducible nuclear factor that interacts with the interleukin-1 response element of the rat α 1-acid glycoprotein gene. Mol Cell Biol 11:3001–3008.Google Scholar
  391. Woo P, Sipe J, Dinarello CA, Colten HR (1987): Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells. J Biol Chem 262:15790–15795.Google Scholar
  392. Wu GY, Wilson JM, Shalaby F, Grossman M, Shafritz DA, Wu CH (1991): Receptor-mediated gene delivery in vivo. Partial correction of genetic anal-buminemia in Nagase rats. J Biol Chem 266(22): 14338–14342.Google Scholar
  393. Wu CH, Wilson JM, Wu GY (1989): Targeting genes: Delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo. J Biol Chem 264:16985–16987.Google Scholar
  394. Wu GY, Wu CH (1988): Receptor-mediated gene delivery and expression in vivo. J Biol Chem 263:14621–14624.Google Scholar
  395. Wu J, Zhou ZY, Judd A, Cartwright CA, Robinson WS (1990): The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/thereonine kinase. Cell 63(4):687–695.CrossRefGoogle Scholar
  396. Wuarin J, Schibier U (1990): Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm. Cell 63:1257–1266.CrossRefGoogle Scholar
  397. Wuarin J, Mueller C, Schibler U (1990): A ubiquitous CCAAT factor is required for efficient in vitro transcription from the mouse albumin promoter. J Mol Biol 214:865–874.CrossRefGoogle Scholar
  398. Xanthopoulos KG, Mirkovitch J, Decker T, Kuo CF, Darnell JE Jr (1989): Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP. Proc Natl Acad Sci USA 86:4117–4121.CrossRefGoogle Scholar
  399. Xanthopoulos KG, Prezioso VR, Chen WS, Sladek FM, Cortese R, Darnell JE Jr (1991): The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc Natl Acad Sci USA 88(9):3807–3811.CrossRefGoogle Scholar
  400. Yamada K, Noguchi T, Matsuda T, Monaci P, Nicosia A, Tanaka T (1990): Identification and characterization of hepatocyte-specific regulatory regions of the rat pyruvate kinase L gene. J Biol Chem 265:19885–19891.Google Scholar
  401. Yang N-S, Burkholder J, Roberts B, Martinell B, McCabe D (1990): In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 87:9568–9572.CrossRefGoogle Scholar
  402. Yee J-K (1989): A liver-specific enhancer in the core promoter region of human hepatitis B virus. Science 246:658–661.CrossRefGoogle Scholar
  403. Yokode M, Hammer RE, Ishibashi S, Brown MS, Goldstein JL (1990): Diet-induced hypercholesterolemia in mice: Prevention by overexpression of LDL receptors. Science 250:1273–1275.CrossRefGoogle Scholar
  404. Yuh C-H, Ting L-P (1990): The genome of hepatitis B virus contains a second enhancer: Cooperation of two elements within this enhancer is required for its function. J Virol 64:4281–4287.Google Scholar
  405. Yuh C-H, Ting L-P (1991): C/EBP-like proteins binding to the functional boxα and box-β of the second enhancer of hepatitis B virus. Mol Cell Biol 11:5044–5052.Google Scholar
  406. Zabel U, Baeuerle PA (1990): Purified human IkB can rapidly dissociate the complex of the NF-kB transcription factor with its cognate DNA. Cell 61:255–265.CrossRefGoogle Scholar
  407. Zhang D-E, Hoyt PR, Papaconstantinou J (1990): Localization of DNA protein-binding sites in the proximal and distal promoter regions of the mouse α-fetoprotein gene. J Biol Chem 265:3382–3391.Google Scholar
  408. Zhang X-K, Dong J-M, Chiu J-F (1991): Regulation of α-fetoprotein gene expression by antagonism between AP-1 and the glucocorticoid receptor at their overlapping binding site. J Biol Chem 266:8248–8254.Google Scholar
  409. Zhong W, Sladek FM, Darnell J Jr. (1993): The expression pattern of a Droso-phila homolog to the mouse transcription factor HNF-4 suggests a determinative role in the gut formation. EMBO J 12:537–544.Google Scholar
  410. Zhou D-X, Yen TSB (1990): Differential regulation of the hepatitis B virus surface gene promoters by a second viral enhancer. J Biol Chem 265:20731–20734.Google Scholar
  411. Zhou D-X, Yen TSB (1991): The ubiquitous transcription factor Oct-1 and the liver-specific factor HNF-1 are both required to activate transcription of a hepatitis B virus promoter. Mol Cell Biol 11:1353–1359.Google Scholar
  412. Zhou D-X, Taraboulos A, Ou JH, Yen TSB (1990): Activation of class I histocompatibility complex gene expression by hepatitis B virus. J Virol 64(8):4025–4028.Google Scholar
  413. zur Hausen H (1991): Viruses in human cancers. Science 254:1167–1173.CrossRefGoogle Scholar

Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Gennaro Ciliberto
  • Vittorio Colantuoni
  • Raffaele De Francesco
  • Vincenzo De Simone
  • Paolo Monaci
  • Alfredo Nicosia
  • Dipak P. Ramji
  • Carlo Toniatti
  • Riccardo Cortese

There are no affiliations available

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