Transcription Factors Controlling Muscle-Specific Gene Expression

  • John J. Schwarz
  • James F. Martin
  • Eric N. Olson
Part of the Progress in Gene Expression book series (PRGE)


Understanding the mechanisms responsible for activation of cell-type-specific gene expression during development is a fundamental problem in molecular biology. Skeletal muscle has provided an important system for investigating this problem because differentiation of skeletal myoblasts is accompanied by the coordinate induction of a battery of genetically unlinked muscle-specific genes whose products are required for the specialized functions of the mature muscle fiber. Analysis of the events associated with muscle differentiation has also been facilitated by the availability of established muscle cell lines that differentiate rapidly and synchronously and whose differentiation can be negatively regulated by individual peptide growth factors or activated oncogenes encoding proteins which transduce growth factor signals from the cell membrane to the nucleus.


Serum Response Factor Muscle Cell Line Myogenic Factor MyoD Family bHLH Region 
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© Birkhäuser Boston 1993

Authors and Affiliations

  • John J. Schwarz
  • James F. Martin
  • Eric N. Olson

There are no affiliations available

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