Control of Transcription and Cellular Proliferation by cAMP

  • Marc R. Montminy
Part of the Progress in Gene Expression book series (PRGE)


Cyclic AMP (cAMP) regulates a striking number of physiological processes, including intermediary metabolism, cellular proliferation, and neuronal signaling, by altering basic patterns of gene expression. In the liver, for example, cAMP stimulates glucose production in part by inducing the transcription of the gene for phosphoenol-pyruvate carboxy-kinase (PEPCK), a rate-limiting gluconeogenic enzyme, more than 15 fold (Lamers et al., 1982; Sasaki et al., 1984). The transcriptional induction by cAMP is rapid, peaking at 30 min and declining gradually over 24 h. This burst in transcription does not depend on new protein synthesis and suggests, therefore, that transcriptional modulation by cAMP involves the covalent modification of a preexisting nuclear factor. Because all the known cellular effects of cAMP occur via cAMP-dependent protein kinase, it appears that phosphorylation is the most likely mechanism by which cAMP would regulate gene expression.


PC12 Cell Bovine Leukemia Virus Phosphoenolpyruvate Carboxykinase Dimerization Domain CREB Protein 
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© Birkhäuser Boston 1993

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  • Marc R. Montminy

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