The Basic Transcriptional Machinery

  • Stefan G. E. Roberts
  • Michael R. Green
Part of the Progress in Gene Expression book series (PRGE)


Recent years have seen a vast increase in our understanding of the mechanisms by which gene transcription is initiated. Indeed, several of the components of the transcriptional machinery have now been cloned, and current work is concentrating on the function of these proteins and the way in which they assemble to form the transcriptionally competent preinitiation complex. The preinitiation complex is an obvious target for the action of sequence specific transcription factors including those involved in cell-type-specific gene expression.


General Transcription Factor TATA Binding Protein Preinitiation Complex Basic Transcriptional Machinery HeLa Nuclear Extract 


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© Birkhäuser Boston 1993

Authors and Affiliations

  • Stefan G. E. Roberts
  • Michael R. Green

There are no affiliations available

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