Cerebral Metabolic Rates of 2-[18F]Fluoro-2-Deoxy-D-Glucose in the Presence of Ofloxacin A GABAA Receptor Antagonist
The involvement of the γ-aminobutyric acid (GABA) receptors in the mediation of inhibitory activity in the central nervous system has been well documented (Nistri and Constanti, 1979; Tallman and Gallager, 1985). Agents that block GABA receptors are potentially excitatory, in that they decrease inhibitory activity in the central nervous system. The reported hyperexcitability caused by some quinolones may be explained on the basis of their action as GABA receptor-blocking agents (Tsuji et al., 1988).
KeywordsPositron Emission Tomography Imaging Cerebral Metabolic Rate GABAA Receptor Antagonist Quinolone Derivative Positron Emission Tomography Imaging Study
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