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Cerebral Metabolic Rates of 2-[18F]Fluoro-2-Deoxy-D-Glucose in the Presence of Ofloxacin A GABAA Receptor Antagonist

  • Edwaldo E. Camargo
  • Zsolt Szabo
  • Robert F. Dannals
  • Henry N. WagnerJr.

Abstract

The involvement of the γ-aminobutyric acid (GABA) receptors in the mediation of inhibitory activity in the central nervous system has been well documented (Nistri and Constanti, 1979; Tallman and Gallager, 1985). Agents that block GABA receptors are potentially excitatory, in that they decrease inhibitory activity in the central nervous system. The reported hyperexcitability caused by some quinolones may be explained on the basis of their action as GABA receptor-blocking agents (Tsuji et al., 1988).

Keywords

Positron Emission Tomography Imaging Cerebral Metabolic Rate GABAA Receptor Antagonist Quinolone Derivative Positron Emission Tomography Imaging Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bartlett MS (1937): Some examples of statistical methods of research in agriculture and applied biology. JR Statist Soc (Suppl) 4: 137–170.Google Scholar
  2. Box GEP (1953): Non-normality and tests on variances. Biometrika 40: 318–335.Google Scholar
  3. Cochran WG (1941): The distribution of the largest of a set of estimated variances as a fraction of their total. Ann Eugen (London) 11: 47–52.CrossRefGoogle Scholar
  4. Duara R, Grady C, Haxby J, Ingvar D, Sokoloff L, Margolin RA, Manning RG, Cutler NR and Rapoport RI (1984): Human brain glucose utilization and cognitive function in relation to age. Ann Neurol 16: 702–713.CrossRefGoogle Scholar
  5. Duara R, Gross-Glenn K, Barker WW, Chang JY, Apicella A, Lowenstein D and Boothe T (1987): Behavioral activation and the variability of cerebral glucose metabolic measurements. J Cereb Blood Flow Metab 7: 266–271.CrossRefGoogle Scholar
  6. Guilarte TR, Miceli RC and Camargo EE (1989): Personal communication.Google Scholar
  7. Hamacher K, Coenen HH and Stocklin G (1986): Efficient stereospecific synthesis of no-carrier-added 2-[18F]fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 27: 235–238.Google Scholar
  8. Heiss WD, Pawlik G, Herholz K, Wagner R, Goldner H and Weinhard K (1984): Regional kinetic constants and cerebral metabolic rate for glucose in normal human volunteers determined by dynamic positron emission tomography of [18F]-2-fluoro-2-deoxyglucose. J Cereb Blood Flow Metab 4: 212–223.CrossRefGoogle Scholar
  9. Huang SC, Phelps ME, Hoffman EJ, Sideris K, Selin CJ and Kuhl DE (1989): Non-invasive determination of local cerebral metabolic rate of glucose in man. Am J Physiol 238: E89–E69.Google Scholar
  10. Metz JT, Odeh H and Cooper MD (1989): “First session” effects in PET studies. J Nucl Med 30: 899.Google Scholar
  11. Monk JP and Campoli-Richards DM (1987): Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 33: 346–391.CrossRefGoogle Scholar
  12. Nistri A and Constanti A (1979): Pharmacological characterization of different types of GABA and glutamate receptors in vertabrates and invertebrates. Prog Neurobiol 13: 117–235.CrossRefGoogle Scholar
  13. Sato K, Matsuura Y, Inoue M, Une T, Osada Y, Ogawa H and Mitsuhashi S (1982): In vitro and in vivo activity of DL-8280, a new oxazine derivative. Antimicrob Agents Chemother 22: 548–553.Google Scholar
  14. Tallman JF and Gallager DW (1985): The GABA-ergic system: a locus of benzodiazepine action. Ann Rev Neurosci 8: 21–44.CrossRefGoogle Scholar
  15. Tsuji A, Sato H, Kume Y, Tamai I, Okezaki E, Hagata O and Kato H (1988): Inhibitory effects of quinolone antibacterial agents of g-aminobutyric acid binding to receptor sites in rat brain membranes. Antimicrob Agents Chemother 32: 190–194.Google Scholar
  16. Tukey JW (1949):. Comparing individual means in the analysis of variance. Biometrics 5: 99–114.CrossRefGoogle Scholar
  17. Tyler JL, Strother SC, Zatorre RJ, Alivisatos B, Worsley KJ, Diksic M and Yamamoto YL (1988): Stability of regional cerebral glucose metabolism in the normal brain measured by positron emission tomography. J Nucl Med 29: 631–642.Google Scholar
  18. Van Caekenberghe DL and Pattyn SR (1984): In vitro activity of ciprofloxacin compared with those of other new fluorinated piperazinyl-substituted quinolone derivatives. Antimicrob Agents Chemother 25: 518–521.Google Scholar

Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Edwaldo E. Camargo
    • 1
  • Zsolt Szabo
    • 1
  • Robert F. Dannals
    • 1
  • Henry N. WagnerJr.
    • 1
  1. 1.Department of Radiology and Radiological ScienceThe Johns Hopkins Medical InstitutionsUSA

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