Application of Nuclear Imaging to Drug Delivery Evaluation and Development: A Review of Radiolabeled, Injectable, Colloidal Systems of Delivery

  • Nancy J. Brenner
  • Christine Fioravanti
  • H. Donald Burns


The formulation or vehicle for a drug varies with the method of required administration (for example, oral, intravenous, intramuscular, or intraperitoneal) and, in some cases, according to which organs or tissues are targeted. Emulsions have been widely used as drug formulations for oral administration for many years, and recently, interest in emulsions as formulations for intravenous use has increased. This interest stems primarily from the fact that the distribution of a lipophilic drug can be altered if it is administered in an emulsion formulation. In addition, emulsions can be used to develop formulations of lipid soluble drugs which are not very soluble in aqueous solutions. Of particular interest are micro and nanocolloidal particles, liposomes, fat emulsions, and microfine emulsions.


High Performance Liquid Chromatography Nuclear Imaging Drug Vehicle Drug Analogue Lipid Soluble Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Boston 1993

Authors and Affiliations

  • Nancy J. Brenner
    • 1
  • Christine Fioravanti
    • 1
  • H. Donald Burns
    • 1
  1. 1.Merck Research LaboratoriesUSA

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