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Alzheimer’s Disease and the Cerebral Amyloidoses

  • Thomas M. Wisniewski
  • Henryk M. Wisniewski

Abstract

Alzheimer’s disease (AD) is the most common illness characterized by the accumulation of amyloid. It was first described by Alois Alzheimer in 1907, when it was regarded as a rare and inconsequential neuropathological entity. However, since that time there has been a major reappraisal of the pathological basis of common senile dementia. AD is now known to cause well over half of the senile dementias and has become a medical, social, and economic problem of enormous dimensions. Nearly 5% of the population over the age of 65 is severely demented and approximately another 10% moderately so. Furthermore, in most Western countries it is the population over the age of 75 that is growing at the fastest rate. With advancing age, a significant proportion of the population returns to a kind of second childhood, handing over responsibility for their own care to the rest of society. Indeed, some researchers view AD as a reversal of development. There are many analogies between childhood and dementia, such as the dependency and the infantile position of advanced AD patients (Reisberg et al., 1990). Studies of aged animals and humans reveal that with the passage of time the cells, organs, and organism accumulate changes that are not seen during their peak function. One such substance that accumulates is amyloid.

Keywords

Familial Mediterranean Fever Amyloid Fibril Cerebral Amyloid Angiopathy Neuritic Plaque Systemic Amyloidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Allsop D, Landon M, Kidd M, Lowe JS, Reynolds GP, Gardner A (1986): Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque core, plaque periphery and cerebrovascular amyloid in Alzheimer’s disease. Neurosci Lett 68:252–256CrossRefGoogle Scholar
  2. Allsop D, Wong CW, Ikeda SK, Landon M, Kidd M, Glenner GG (1988): Im-munohistological evidence for derivation of a peptide ligand from the amyloid a-protein precursor of Alzheimer’s disease. Proc Nat Acad Sci USA 85:2790–2794CrossRefGoogle Scholar
  3. Alzheimer A (1907): Uberline eigenartige erkrangkung der hirnrinde. Allg Z Psy-chiat 64:146–148Google Scholar
  4. Bahmanyar S, Higgins A, Goldgaber D, Lewis DA, Morrison JH, Wilson MC, Shanker SK, Gadjusek DC (1987): Localization of amyloid β-protein messenger RNA in brains from patients with Alzheimer’s disease. Science 237:77–80CrossRefGoogle Scholar
  5. Benditt EP, Erikssen N, Hermodson NA, Ericsson LH (1971): The major proteins of human and monkey amyloid substance: common properties including unusual N-terminal amino acids sequences. FEBS Lett 19:169.Google Scholar
  6. Benson MD, Kleiner E (1980): Synthesis and secretion of serum amyloid protein A (SAA) by hepatocytes in mice treated with casein. J Immunol 124:495–499Google Scholar
  7. Castano EM, Frangione B (1988): Biology of Disease: Human amyloidosis, Alzheimer’s disease and related disorders. Letts Invest 58:122–132Google Scholar
  8. Cohen DH, Feiner H, Jensson D, Frangione B (1983): Amyloid fibril in hereditary cerebral hemorrhage with amyloidosis (HCHWA) is related to the gastroen-teropancreatic neuroendocrine protein gamma trace. J Exp Med 158:623.Google Scholar
  9. Corsellis Jan (1962): Mental Illness and the Aging Brain. Institute of Psychiatry, Maudsley Monographs, No. 9, Oxford University PressGoogle Scholar
  10. Cunningham BA, Hemperly TJ, Murray BA, Prediger EA, Brackenburg R, Edel-Man GM (1987): Neuronal cell adhesion molecule: structure immunoglobulin-like domains, cell surface modulation and alternative RNA splicing. Science 236:799–806CrossRefGoogle Scholar
  11. Currie J, Wisniewski HM, Chauhan A, Brockerhoff H, Wegiel J (1990): Alzheimer amyloid β-protein: Cell of origin and possible fusogenic and membranolytic properties. In: Regulation of Gene Expression in the Nervous System, Giuffida A, de Vellis J, eds. Alan R. Liss, in press.Google Scholar
  12. Dunlop DS (1983): Protein turn-over in brain: Synthesis and degradation. In: Handbook of Neurochemistry, Lajtha A, ed. New York: Plenum Press, pp. 25–65Google Scholar
  13. Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, Oltersdork T, Mc-Clure D, Ward PJ (1990): Cleavage of amyloid β-peptide during constitutive processing of its precursor. Science 248:1122–1124CrossRefGoogle Scholar
  14. Galloway PG, Perry G, Gambetti P (1988): Hirano body filaments contain actin and actin associated proteins. J Neuropathol Exp Neurol 46:185–199CrossRefGoogle Scholar
  15. Ghiso G, Jensson O, Frangione B (1986): Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic Type is a variant of gamma-trace basic protein (Cystatin C). Proc Natl Acad Sci USA 83:2974.Google Scholar
  16. Glenner GG, Terry W, Harada M, Isersky C, Paye C (1971a): Amyloid fibril proteins: proof of nomology with immunoglobulin light chains by sequence analysis. Science 172:1150CrossRefGoogle Scholar
  17. Glenner GG, Ein D, Eanes ED, Bladen HA, Terry W, Page D (1971b): Creation of amyloid fibrils from Bence Jones proteins in vitro. Science 174:712.Google Scholar
  18. Glenner GG (1979): Congophilic microangiopathy in the pathogenesis of Alzheimer’s syndrome (presenile dementia). Med Hypotheses 5:1231–1236CrossRefGoogle Scholar
  19. Glenner GG (1980): Amyloid deposits and amyloidosis: The α-fibrilloses. N Engl J Med 302:1283CrossRefGoogle Scholar
  20. Glenner GG, Henry JH, Fujihara S (1981): Congophilic angiopathy in the pathogenesis of Alzheimer’s degeneration. Ann Pathol 1:120–129Google Scholar
  21. Glenner GG, Wong CW (1984a): Alzheimer’s disease and Down’s syndrome: Sharing of a unique cerebrovascular amyloid protein. Biochem Biophys Res Commun 122:1131–1135CrossRefGoogle Scholar
  22. Glenner GG, Wong CW (1984b): Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885–890CrossRefGoogle Scholar
  23. Goate A, Chartier-Harlin MC, Brown J, Crawford F, Fidami L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rosser M, Owen M, Hardy J (1991): Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 349:704–706CrossRefGoogle Scholar
  24. Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC (1987): Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease. Science 235:877–880CrossRefGoogle Scholar
  25. Grubb A, Lofberg H (1984): Human trace, a basic microprotein: Amino acid sequences and presence in the adenohypophysis. Proc Natl Acad Sci USA 79:3024CrossRefGoogle Scholar
  26. Gudmundsson G, Hallgrimsson J, Jonasson TA, Bjarnason O (1972): Hereditary cerebral hemorrhage and amyloidosis. Brain 95:587CrossRefGoogle Scholar
  27. Hirano A, Dembitzer HM, Kurland LT, Zimmerman HM (1968): The fine structure of some intraganglionic alterations: Neurofibrillary tangles, granulovac-uolar bodies and “rod-like” structures as seen in Guam amyotrophic lateral sclerosis and Parkinson dementia complex. J Neuropathol Exp Neurol 27:167–182CrossRefGoogle Scholar
  28. Hirano A, Malamud N, Kurland LT (1961): Parkinsonism-dementia complex, an endemic disease on the Island of Guam. Brain 84:662–679CrossRefGoogle Scholar
  29. Hirano A, Zimmerman HM (1962): Alzheimer’s neurofibrillary changes. Arch Neurol 7:227–241CrossRefGoogle Scholar
  30. Hooper MW, Vogel FS (1976): The limbic system in Alzheimer’s disease: A neuropathologic investigation. Amer J Pathol 85:1–20Google Scholar
  31. Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D (1989): Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol 24:173–182CrossRefGoogle Scholar
  32. Joachim CL, Duffy LK, Morris JH, Selkoe DJ (1988): Protein chemical and immunocytochemical studies of meningovascular-vascular ß-amyloid protein in Alzheimer’s disease and normal aging. Brain Res 474:100–101CrossRefGoogle Scholar
  33. Johnson SA, McNeil T, Cordell B, Finch CE (1990): Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer’s disease. Science 248:854–857CrossRefGoogle Scholar
  34. Kang J, Lemaire HG, Unterbeck A et al. (1987): The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733–736CrossRefGoogle Scholar
  35. Kingsbury DW (1985): Orthomyxo and paramyxoviruses and their replication. In: Virology, Fields et al., eds. New York: Raven Press, pp. 1151–1178Google Scholar
  36. Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H (1988): Novel precursors of Alzheimer’s disease protein shows protease inhibitory activity. Nature 331:530–532CrossRefGoogle Scholar
  37. Lavie G, Zucker-Franklin D, Franklin EC (1978): Degradation of serum amyloid A protein by surface-associated enzymes of human blood monocytes. J Exp Med 148:1020–1023CrossRefGoogle Scholar
  38. Levin M, Franklin EC, Frangione B, Pras M (1972): The amino acid sequence of a major non-immunoglobulin component of some amyloid fibrils. J Clin Invest 51:2773–2776CrossRefGoogle Scholar
  39. Levy E, Carman MD, Fernandez-Madrid IJ, Power MD, Lieberburg I, Van Duinen SG, Bots GThAM, Luyendijk W, Frangione B (1990): Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 248:1124–1126CrossRefGoogle Scholar
  40. Luyendijk W, Bots GThAM, Vegter Van der Vlis M, Went LN (1986): Familiaire hersenblocdingen als gevolg van cerebral amyloid angiopathie. Ned Tijdschr Geneesk 130:1935–1940Google Scholar
  41. Masters CL, Multraup G, Simms G, Pottgiesser J, Martius RW, Beyreuther K (1985): Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer’s disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J 4:2747–2763Google Scholar
  42. Miller DL, Currie JR, Iqbal K, Potempska A, Styles J (1989): Relationship among the cerebral amyloid peptides and their precursors. Ann Med 21:83–87CrossRefGoogle Scholar
  43. Miyakawa T, Sumiyoshi S, Murayama E, Deshimaru M (1974): Ultrastructure of capillary plaque-like degeneration in senile dementia. Mechanism of amyloid production. Acta Neuropath (Bed) 29:229–236CrossRefGoogle Scholar
  44. Morrison TG (1988): Structure, function and intracellular processing of paramyxovirus membrane proteins. Virus Res 10:113–136CrossRefGoogle Scholar
  45. Morrow JF, Stearman RS, Peltzman, CO, Potter DA (1981): Induction of hepatic synthesis of serum amyloid A protein and actin. Proc Natl Acad Sci USA 78:4718–4722CrossRefGoogle Scholar
  46. Narlise S, Igarashi S, Aoki K, Kaneko K, Ihara K, Miyatake T, Kobayashi H, Inuzuka T, Schimizu T, Kojima T, Tsuji S (1991): Missense mutation Val → Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer’s. Lancet 337:978–979Google Scholar
  47. Palmert MR, Golde TE, Cohen ML et al. (1988): Amyloid protein precursor messenger RNAs: Differential expression in Alzheimer’s disease. Science 241:1080–1084CrossRefGoogle Scholar
  48. Ponti P, Gonzalez De Whitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Leiderberg I, Fuller F, Cordell B (1988): A new A4 amyloid mRNA contains a domain homologous to a serine proteinase inhibitor. Nature 331:525–527CrossRefGoogle Scholar
  49. Powers JM (1986): Senile cerebral amyloid-evidence for a neuronal origin of the fibril protein. In: Amyloidosis, Glenner GG, Osserman EF, Benditt EP, Calkins E, Cohen AS, Zucker-Franklin, D, eds. Plenum Press, pp.743–749Google Scholar
  50. Powers JM, Sheen JT (1988): Ultrastructural heterogeneity in cerebral amyloid of Alzheimer’s disease. Acta Neuropath 76:613–623.CrossRefGoogle Scholar
  51. Pras M, Franklin EC, Prelli F, Frangione B (1981): A variant of prealbumen from amyloid fibrils in familial polyneuropathy of Jewish type. / Exp Med 154:989CrossRefGoogle Scholar
  52. Prelli F, Castano E, Glenner GG, Frangione B (1988): Differences between vascular and plaque core amyloid in Alzheimer’s disease. J Neurochem 15:648–651CrossRefGoogle Scholar
  53. Ranlov P, Wanstrup J (1967): Ultrastructural investigations on the cellular morphogenesis of experimental mouse amyloidosis. Acta Pathol Microbiol Scand 71:575–591CrossRefGoogle Scholar
  54. Reisberg B, Pattschull-Furlan A, Franssen E, Sclan S, Kluger A, Dingcong L, Ferris SH (1990). Cognition related functional, praxis and feeding changes in CNS aging and Alzheimer’s disease and their developmental analogies. In: Molecular Mechanisms in Aging, K. Beyreuther ed. Berlin: Springer-Verlag, pp. 18–40Google Scholar
  55. Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM (1987): Molecular cloning and characterization of a cDNA encoding the neuritic plaque amyloid peptides. Proc Nat Acad Sci USA 84:4190–4194CrossRefGoogle Scholar
  56. Selkoe DJ, Abraham CR, Podlismy MB, Duffly LK (1986): Isolation of low-molecular weight proteins from amyloid plaques fibers in Alzheimer’s disease. J Neurochem 46:1820–1834CrossRefGoogle Scholar
  57. Simchowicz T (1911): Histologische Studien über die senile demenz. In: Histologische und Histopathologische Arbeiten uber die grosshirnrinde. Nissl F, Alzheimer A, eds. Gustav Fisher, 4:267–444Google Scholar
  58. Sletten K, Husby G, Natvig JB (1974): N-terminal amino acid sequence of amyloid fibril protein AR, prototype of a new lambda-variable subgroup Vrl. Scand J Immunol 3:831–836Google Scholar
  59. Sorenson GD, Hoefner WA, Kiewpatrick JP (1964): Experimental amyloidosis II. Light and electron microscopic observations of liver. Am J Pathol 44:629–644Google Scholar
  60. St. George-Hyslop PH, Tanzi RE, Polinsky J et al. (1987): The genetic defect causing familial Alzheimer’s disease maps on chromosome 21. Science 235:885CrossRefGoogle Scholar
  61. Tagliavini F, Giaccone G, Frangione B, Bugiani O (1988): Pre-amyloid deposits in the cerebral cortex of patients with Alzheimer’s disease and non-demented individuals. Neuroscience Lett 93:191–196CrossRefGoogle Scholar
  62. Tanzi, RE, Gusella JF, Watkins PC et al. (1987): Amyloid β-protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus. Science 235:880–884CrossRefGoogle Scholar
  63. Tanzi RE, McClatchey AI, Lamperti ED et al. (1988): Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer’s disease. Nature 331:528–530CrossRefGoogle Scholar
  64. Uchino F, Takahashi M, Yokota T, Ishihara T (1985): Experimental amyloidosis. Role of hepatocyte and Kuffer cells in amyloid formation. Appl Pathol 3:78–87Google Scholar
  65. Van Broeckhaven C, Haan J, Bakker E, Hardy JA, Van Hul W, Wehnert A, Vegter Van der Vlis M, Roos RAC (1990): Amyloid β-protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science 248:1120–1122CrossRefGoogle Scholar
  66. Van Duinen SG, Castano EM, Prelli F, Bots GThAB, Luyendijk W, Frangione B (1987): Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer’s disease. Proc Natl Acad Sci USA 84:5991–5994CrossRefGoogle Scholar
  67. Van Nostrand WE, Schmaier Farrow JS, Cunningham DD (1990): Protease Nexin II (Amyloid β-protein precursor): A platelet a-granule protein. Science 248: 745–748CrossRefGoogle Scholar
  68. Wattendosff AR, Bots GThAM, Went LN, Endtz LJ (1982): Familial cerebral amyloid angiopathy presenting as recurrent cerebral hemorrhage. J Neurol Sci 55:121CrossRefGoogle Scholar
  69. Wiley DC (1985): Viral membranes. In: Virology, Fields et al., eds. New York: Raven Press, pp. 45–67Google Scholar
  70. White J, Kielian M, Helenius A (1983): Membrane fusion proteins of enveloped animal viruses. Quart Rev Biophys 16:151–195CrossRefGoogle Scholar
  71. Wisniewski HM, Terry RD (1973): The examination of the pathogenesis of senile plaques. In: Progress in Neuropathology, Vol 2. Zimmer HM, ed. New York: Grune and Stratton, pp. 1–26Google Scholar
  72. Wisniewski HM, Narang HK, Corsellis JAN, Terry RD (1976): Ultrastructural studies of the neuropil and neurofibrillary tangles in Alzheimer’s disease and post-traumatic dementia. J Neuropathol Exp Neurol Abst. 35:367CrossRefGoogle Scholar
  73. Wisniewski HM, Moretz RC, Lossinsky AS (1981): Evidence for induction of localized amyloid deposits and neuritic plaques by an infectious agent. Ann Neurol 10:517–522CrossRefGoogle Scholar
  74. Wisniewski HM, Bancher C, Barcikowska M, Wen GY, Currie J (1989a): Spectrum of morphological appearance of amyloid deposits in Alzheimer’s disease. Acta Neuropathol 78:337–347CrossRefGoogle Scholar
  75. Wisniewski HM, Wegiel J, Wang KC, Kujawa M, Lach B (1989b): Ultrastructural studies of the cells forming amyloid fibers in classical plaques. Can J Neurol Sci 16:535–542Google Scholar
  76. Wisniewski HM, Vorbrodt AW, Wegiel J, Morys J, Lossinsky AS (1990): Ultra-structure of the cells forming amyloid fibers in Alzheimer disease and scrapie. Am J Med Genetics, Suppl 7:287–297Google Scholar
  77. Wisniewski HM, Barcikowska M, Kida E (1991): Phagocytois of B/A4 amyloid fibrils of the neuritic neocortical plaques, Acta Neuropathol 81:588–590CrossRefGoogle Scholar
  78. Wisniewski K, Jervis GA, Moretz RC, Wisniewski HM (1979): Alzheimer neurofibrillary tangles in diseases and other than senile and presenile dementia. Ann Neurol 5:228–294CrossRefGoogle Scholar
  79. Wong CW, Quaranta V, Glenner GG (1985): Neuritic plaques and cerebrovascular amyloid in Alzheimer’s disease are antigenically related. Proc Natl Acad Sci USA 82:8729–8732CrossRefGoogle Scholar
  80. Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Harigaya Y (1988): Acta Neuropathol (Berl) 71:113Google Scholar

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© Birkhäuser Boston 1992

Authors and Affiliations

  • Thomas M. Wisniewski
  • Henryk M. Wisniewski

There are no affiliations available

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