Neuroendocrine Changes in Aging and Alzheimer’s Disease

  • D. F. Swaab
  • E. Goudsmit
  • H. P. H. Kremer
  • R. Ravid
  • W. Witting


Alterations in hypothalamic structures and functions are thought to be causal in diseases such as anorexia nervosa, depression, Cushing’s disease, diabetes insipidus, Prader-Willi-syndrome, polycystic ovaries syndrome, and the malignant neuroleptic syndrome, as well as in disturbances in sleep and temperature regulation. In addition, the hypothalamus is affected in neurodegenerative diseases and might be responsible for particular symptoms, e.g., in Alzheimer’s, Parkinson’s and Huntington’s diseases and possibly in multiple sclerosis. Moreover, this brain region is presumed to be altered in adrenogenital syndrome, by hormones given during development (e.g., diethylstibestrol (DES)), and in Turner’s, Klinefelter’s and Kallman’s syndromes.


Circadian Rhythm Anorexia Nervosa Suprachiasmatic Nucleus Preoptic Area Neuroendocrine Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Boston 1992

Authors and Affiliations

  • D. F. Swaab
  • E. Goudsmit
  • H. P. H. Kremer
  • R. Ravid
  • W. Witting

There are no affiliations available

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