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Emerging Strategies in Neuroprotection pp 326–343Cite as

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Excitotoxicity and Neurodegenerative Disorders

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Part of the book series: Advances in Neuroprotection ((AN,volume 22))

Abstract

The excitatory amino acids (EAA) glutamate (Glu) and aspartate (Asp) are now recognized as key participants in a variety of physiologic and pathologic processes. On the one hand, these agents are likely to function as neurotransmitters at the majority of fast excitatory synapses in the vertebrate central nervous system (CNS), playing roles in normal synaptic transmission (Collingridge and Lester, 1989; Mayer and Westbrook, 1987a) and several forms of synaptic plasticity (Kuba and Kumamoto, 1990). Yet exposure of neurons to these agents clearly has toxic consequences, prompting hypotheses regarding the involvement of EAA in human neuro-degenerative syndromes (Olney, 1990). In this chapter we will review evidence linking EAA to specific neuropsychiatric syndromes.

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Authors
  1. Charles F. Zorumski
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  2. John W. Olney
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Editors and Affiliations

  1. NeuroTherapeutics Corp. and Center for Neurologic Study, 11211 Sorrento Valley Road, 92121, San Diego, CA, USA

    Paul J. Marangos

  2. Department of Pharmacology, Texas College of Osteopathic Medicine, 3500 Camp Bowie Boulevard, 76107, Fort Worth, TX, USA

    Harbans Lal

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Zorumski, C.F., Olney, J.W. (1992). Excitotoxicity and Neurodegenerative Disorders. In: Marangos, P.J., Lal, H. (eds) Emerging Strategies in Neuroprotection. Advances in Neuroprotection, vol 22. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4684-6796-3_17

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