Excitotoxicity and Neurodegenerative Disorders

  • Charles F. Zorumski
  • John W. Olney
Part of the Advances in Neuroprotection book series (volume 22)


The excitatory amino acids (EAA) glutamate (Glu) and aspartate (Asp) are now recognized as key participants in a variety of physiologic and pathologic processes. On the one hand, these agents are likely to function as neurotransmitters at the majority of fast excitatory synapses in the vertebrate central nervous system (CNS), playing roles in normal synaptic transmission (Collingridge and Lester, 1989; Mayer and Westbrook, 1987a) and several forms of synaptic plasticity (Kuba and Kumamoto, 1990). Yet exposure of neurons to these agents clearly has toxic consequences, prompting hypotheses regarding the involvement of EAA in human neuro-degenerative syndromes (Olney, 1990). In this chapter we will review evidence linking EAA to specific neuropsychiatric syndromes.


Amyotrophic Lateral Sclerosis Excitatory Amino Acid NMDA Antagonist Domoic Acid Excitatory Amino Acid Receptor 
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© Birkhäuser Boston 1992

Authors and Affiliations

  • Charles F. Zorumski
  • John W. Olney

There are no affiliations available

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