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Emerging Strategies in Neuroprotection pp 289–306Cite as

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Temperature Modulation of Neuronal Injury

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Part of the book series: Advances in Neuroprotection ((AN,volume 22))

Abstract

The concept of altering the body temperature to achieve a therapeutic result in an injured brain is not new. Much has been written, both in the experimental and clinical literature, on therapeutic hypo- and hyperthermia. The protective effect of profound hypothermia (30°C or less) has been well established during cardiac and intracranial surgical procedures necessitating interruption of blood flow to the brain. Hypothermia has also been and continues to be used in the head-injured patient for the control of increased intracranial pressure that is refractory to hyperventilation, ventricular drainage, osmotherapy, and barbiturates. Conversely, the adjunctive chemotherapeutic effect of selective brain tumor hyperthermia remains under intense investigation.

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Authors
  1. Mordecai Y.-T. Globus
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  2. Raul Busto
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  3. W. Dalton Dietrich
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  4. Linda Sternau
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  5. Eiharu Morikawa
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  6. Myron D. Ginsberg
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Editors and Affiliations

  1. NeuroTherapeutics Corp. and Center for Neurologic Study, 11211 Sorrento Valley Road, 92121, San Diego, CA, USA

    Paul J. Marangos

  2. Department of Pharmacology, Texas College of Osteopathic Medicine, 3500 Camp Bowie Boulevard, 76107, Fort Worth, TX, USA

    Harbans Lal

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© 1992 Birkhäuser Boston

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Globus, M.YT., Busto, R., Dietrich, W.D., Sternau, L., Morikawa, E., Ginsberg, M.D. (1992). Temperature Modulation of Neuronal Injury. In: Marangos, P.J., Lal, H. (eds) Emerging Strategies in Neuroprotection. Advances in Neuroprotection, vol 22. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4684-6796-3_15

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  • DOI: https://doi.org/10.1007/978-1-4684-6796-3_15

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  • Publisher Name: Birkhäuser, Boston, MA

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  • Online ISBN: 978-1-4684-6796-3

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