The Dopamine D2 Receptor

  • Olivier Civelli
  • James Bunzow
  • Paul Albert
  • Hubert H. M. Van Tol
  • David Grandy
Part of the Applications of Molecular Genetics to Pharmacology book series


Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and Calne, 1979). Binding of dopamine to its receptors induces several second messenger systems, most importantly affecting cAMP levels (Vallar and Meldolesi, 1989). Activation of the D1 receptor stimulates adenylyl cyclase activity which results in an increase in intracellular cAMP levels while binding of dopamine to the D2 receptor inhibits the cyclase activity (Caron et al., 1978).


Tourette Syndrome Adenylyl Cyclase Activity Entire Central Nervous System Tuberoinfundibular Tract Affect cAMP Level 
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Copyright information

© Birkhäuser Boston 1992

Authors and Affiliations

  • Olivier Civelli
  • James Bunzow
  • Paul Albert
  • Hubert H. M. Van Tol
  • David Grandy

There are no affiliations available

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