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The Dopamine D1 Receptors

  • Chapter
Molecular Biology of G-Protein-Coupled Receptors

Part of the book series: Applications of Molecular Genetics to Pharmacology ((AMGP))

Abstract

Many psychomotor signs and symptoms are influenced by the activity of dopaminergic neurons and by drugs that selectively interact with neuronal dopamine receptors. These include rigidity in Parkinson’s disease, hallucinations in schizophrenia and Alzheimer’s disease, dyskinesia in Huntington’s chorea, and spontaneous oral dyskinesia in the elderly (Seeman, 1987; Seeman et al., 1987; Seeman and Niznik, 1990). These receptors may also play a significant role in drug addiction and alcoholism (Blum et al., 1990). On the basis of pharmacological, biochemical, and physiological criteria, receptors for dopamine have been classified into two types, termed D1 and D2 (Kebabian and Calne, 1979; Seeman, 1980; Niznik and Jarvie, 1989). These are members of a large gene family of hormone/neurotransmitter receptors that exert their biological actions via signal transduction pathways that involve guanine nucleotide-binding proteins. While D2 dopamine receptors inhibit the activation of adenylyl cyclase and appear to couple to numerous other effector systems, D1 dopamine receptors, found in the brain, retina, and parathyroid gland, stimulate adenylyl cyclase and subsequently activate cAMP-dependent protein kinases (Niznik, 1987; Seeman and Niznik, 1988; Hess and Creese, 1987; Hemmings et al., 1987).

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Authors
  1. Hyman B. Niznik
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  2. Roger K. Sunahara
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  3. Hubert H. M. Van Tol
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  4. Philip Seeman
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  5. David M. Weiner
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  6. Tom M. Stormann
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  7. Mark R. Brann
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  8. Brian F. O’Dowd
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Editor information

Editors and Affiliations

  1. Molecular Neuropharmacology Section Department of Psychiatry College of Medicine, University of Vermont, 05405-0068, Burlington, VT, USA

    Mark R. Brann

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© 1992 Birkhäuser Boston

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Niznik, H.B. et al. (1992). The Dopamine D1 Receptors. In: Brann, M.R. (eds) Molecular Biology of G-Protein-Coupled Receptors. Applications of Molecular Genetics to Pharmacology. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6772-7_6

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  • DOI: https://doi.org/10.1007/978-1-4684-6772-7_6

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4684-6774-1

  • Online ISBN: 978-1-4684-6772-7

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