Structural, Functional, and Genetic Aspects of Receptors Coupled to G-Proteins

  • Brian O’Dowd
  • Sheila Collins
  • Michel Bouvier
  • Marc G. Caron
  • Robert J. Lefkowitz
Part of the Applications of Molecular Genetics to Pharmacology book series


A remarkably diverse array of biologically active substances elicit their actions by interacting with Cell surface receptors which are coupled via guanine nucleotide regulatory proteins (G-proteins) to specific biochemical effectors. Examples include neurotransmitters, hormones, many drugs, and even sensory stimuli such as light and odorants. Perhaps the most thoroughly studied example of such a receptor system is the β2-adrenergic receptor for catecholamines which mediates stimulation of adenylyl cyclase via Gs. Within the past few years its primary structure has become known via molecular cloning, and substantial progress has also been made in learning how its unique structural features determine such specific functions as ligand binding and G-protein activation. Much has also been learned about the mechanisms by which its function is regulated. Moreover, a great deal of this information appears to be generally applicable to the other members of the broad family of G-protein-coupled receptors. This chapter reviews some of the most important information developed over the past several years.


Adenylyl Cyclase Bovine Rhodopsin Rhodopsin Kinase Frog Erythrocyte Guanine Nucleotide Regulatory Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Boston 1992

Authors and Affiliations

  • Brian O’Dowd
  • Sheila Collins
  • Michel Bouvier
  • Marc G. Caron
  • Robert J. Lefkowitz

There are no affiliations available

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