Possible Epileptogenic Consequences of Misused GABAergic Relationships

  • J. Champagnat
  • C. Silva-Barrat
  • S. Brailowsky
  • Ch. Menini


Recent experiments have suggested that an epileptogenic syndrome develops following the interruption of prolonged intracerebral administration of GABA (Brailowsky et al., 1987; Fukuda et al., 1987; Silva-Barrat et al., 1988). An implanted cannula connected to osmotic minipumps provides a simple method for infusing solutions inside the cerebral tissue for several days, with a delivery rate slow enough to prevent extensive cellular damage (Fukuda et al., 1987; see also Brailowsky, Chapter 10, this volume). Using this method, GABA was infused into the somatomotor cortex of rats and baboons chronically (1 to 7 days). Ten to sixty minutes after discontinuation of these infusions, spontaneous cortical EEG paroxysmal spikes were recorded in the previously infused motor area and found to be associated with myoclonic twitches limited to the corresponding body territory. This epileptogenic syndrome has been called the GABA withdrawal syndrome (Brailowsky et al., 1988).


Infusion Site Generalize Epilepsy Gaba Response Extracellular Gaba GABAA Agonist 
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Copyright information

© Birkhäuser Boston, Inc. 1990

Authors and Affiliations

  • J. Champagnat
  • C. Silva-Barrat
  • S. Brailowsky
  • Ch. Menini

There are no affiliations available

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