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Metabolic Studies of Generalized Epilepsy

  • J. EngelJr.
  • R. F. Ochs
  • P. Gloor

Abstract

Positron emission tomography (PET) with [18F] fluorodeoxyglucose (FDG) has been used to study local cerebral metabolic rate for glucose (LCMRGlc) associated with a variety of epileptic conditions. Most published reports are concerned primarily with partial epilepsies (Abou-Khalil et al., 1987; Engel et al., 1982a-d, 1983; Franck et al., 1986; Theodore et al., 1984; Yamamoto et al., 1983), particularly the recognized value of FDG-PET in the selection of patients with medically intractable partial seizures for resective surgical treatment (Engel, 1987). Centers with PET scan facilities have paid less attention to the generalized epilepsies. However, sufficient data are available to allow speculation concerning the potential role for functional imaging in clinical diagnosis of generalized epileptic disorders, as well as for understanding the basic mechanisms of generalized epileptic seizures.

Keywords

Positron Emission Tomography Positron Emission Tomography Study Absence Seizure Infantile Spasm Partial Epilepsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abou-Khalil, B.W., Siegel, G.J., Sackellares, J.C., Gilman, S., Hichwa, R., and Marshall, R., 1987. Positron emission tomography studies of cerebral glucose metabolism in chronic partial epilepsy, Ann. Neurol. 22: 480–486.CrossRefGoogle Scholar
  2. Ackermann, R.F., Chugani, H.T., Caldecott-Hazard, S., and Engel, J. Jr., 1984, Postictal cerebral metabolism-blood flow mismatches observed in hippocampus and substantia nigra of amygdala-kindled rats, Soc. Neurosci. Abstr. 10: 3 (Abstr.).Google Scholar
  3. Ackermann, R.F., Engel, J. Jr., and Baxter L., 1986, PET and autoradiographic studies of glucose utilization following electroconvulsive seizures in humans and rats, Ann. NY Acad. Sci 462: 263–269.CrossRefGoogle Scholar
  4. Chugani, H.T., and Engel, J. Jr., 1986, PET in intractable epilepsy, in: Workshop on Intractable Epilepsy: Experimental and Clinical Aspects (P.L. Morslli and D. Schmidt, eds.), Raven Press, New York, pp. 119–128.Google Scholar
  5. Chugani, H.T., Ackermann, R.F., Chugani, D.C., and Engel, J. Jr., 1984, Opioid-induced epileptogenic phenomena: Anatomical, behavioral, and electroencephalographic features, Ann. Neurol. 15: 361–368.CrossRefGoogle Scholar
  6. Chugani, H.T., Mazziotta, J.C., Engel, J. Jr., and Phelps M.E., 1987, The Lennox-Gastaut syndrome: Metabolic subtypes determined by 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography, Ann. Neurol. 21: 4–13.CrossRefGoogle Scholar
  7. Engel, J. Jr., ed., 1987, Surgical Treatment of the Epilepsies, Raven Press, New York.Google Scholar
  8. Engel, J. Jr., 1988, Comparison of positron emission tomography and electroencephalography as measures of cerebral function in epilepsy, in: Functional Brain Imaging (G. Pfurtscheller and F.H. Lopes da Silva, eds.), Hans Huber, Bern, pp. 229–238.Google Scholar
  9. Engel, J. Jr., and Wilson, C.L., 1986, Evidence for enhanced synaptic inhibition in human epilepsy, in: Neurotransmitters, Seizures, and Epilepsy, Vol. III (G. Nistico, P.L. Morselli, K.G. Lloyd, R.G. Fariello, and J. Engel Jr., eds.), Raven Press, New York, pp. 1–10.Google Scholar
  10. Engel, J., Jr., Wolfson, L., and Brown, L., 1978, Anatomical correlates of electrical and behavioral events related to amygdaloid kindling, Ann. Neurol. 3: 538–544.CrossRefGoogle Scholar
  11. Engel, J. Jr., Brown, W.J., Kuhl, D.E., Phelps, M.E., Mazziotta, J.C., and Crandall, P.H., 1982a, Pathological findings underlying focal temporal lobe hypometabolism in partial epilepsy, Ann. Neurol. 12: 518–528.CrossRefGoogle Scholar
  12. Engel, J. Jr., Kuhl, D.E., and Phelps, M.E., 1982b, Patterns of human local cerebral glucose metabolism during epileptic seizures, Science 218: 64–66.CrossRefGoogle Scholar
  13. Engel, J. Jr., Kuhl, D.E., Phelps, M.E., and Crandall, P.H., 1982c, Comparative localization of epileptic foci in partial epilepsy by PCT and EEG, Ann. Neurol. 12: 529–537.CrossRefGoogle Scholar
  14. Engel, J. Jr., Kuhl, D.E., Phelps, M.E., and Mazziotta, J.C., 1982d, Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes, Ann. Neurol. 12: 510–517.CrossRefGoogle Scholar
  15. Engel, J. Jr., Kuhl, D.E., Phelps, M.E., Rausch, R., and Nuwer, M., 1983, Local cerebral metabolism during partial seizures, Neurology 33: 400–413.Google Scholar
  16. Engel, J. Jr., Lubens, P., Kuhl, D.E., and Phelps, M., 1985, Local cerebral metabolic rate for glucose during petit mal absences, Ann. Neurol. 17: 121–128.CrossRefGoogle Scholar
  17. Engel, J. Jr., Lubens, P., and Phelps, M., 1988, Metabolic correlates of diffuse EEG spike-and-wave and absence seizures, Ann. Neurol. 23: 207 (Letter).CrossRefGoogle Scholar
  18. Franck, G., Sadzot, B., Salmon, E., Depresseux, J.C., Grisar, T., Peters, J.M., Guillaume, M., Quaglia, L., Elfiore, G., and Lamotte, D., 1986, Regional cerebral blood flow and metabolic rates in human focal epilepsy and status epilepticus, in: Advances in neurology, Vol. 44: Basic Mechanisms of the Epilepsies, Molecular and Cellular Approaches (A.V. Delgado-Escueta, A.A. Ward Jr., D.M. Woodbury, and R.J. Porter, eds.), Raven Press, New York, pp. 935–948.Google Scholar
  19. Fromm, G.H., 1986, Role of inhibitory mechanisms in staring spells, J. Clin. Neurophysiol. 3: 297–311.CrossRefGoogle Scholar
  20. Gloor, P., and Fariello, R.G., 1988, Generalized epilepsy: Some of its cellular mechanisms differ from those of focal epilepsy, Trends Neuroscie. 11: 63–68.CrossRefGoogle Scholar
  21. Gur, R.C., Sussman, N.M., Alavi, A., Gur, R.E., Rosen, A.D., O’Connor, M., Goldberg, H.I., Greenberg, J.H., and Reivich, M., 1982, Positron emission tomography in two cases of childhood epileptic encephalopathy (Lennox-Gastaut syndrome), Neurology 32: 1191–1194.Google Scholar
  22. Henry, T.R., Engel, J. Jr., and Mazziotta, J.C., 1988, PET studies of functional cerebral anatomy in human epilepsy, in: Anatomy of Epilep-togenesis (B.S. Meldrum, J. Ferendelli, and H.G. Wieser, eds.), John Libbey Eurotext, London, pp. 155–178.Google Scholar
  23. Kellaway, P., Frost, J.D. Jr., and Hrachovy, R.A., 1983, Infantile spasms, in: Antiepileptic Drug Therapy in Pediatrics (P.L. Morselli, C.E. Pippenger, and J.K. Penry, eds.), Raven Press, New York, pp. 115–136.Google Scholar
  24. Loiseau, P., 1985, Childhood absence epilepsy, in: Epileptic Syndromes in Infancy, Childhood and Adolescence (J. Roger, C. Dravet, M. Bureau, F.E. Dreifuss, and P. Wolf, eds.), John Libbey Eurotext, London, pp. 106–120.Google Scholar
  25. Ochs, R.F., Gloor, P., Tyler, J.L., Wolfson, T., Worsley, K., Andermann, F., Diksic, M., Meyer, E., and Evans, A., 1987, Effect of generalized spike-and-wave discharge on glucose metabolism measured by positron emission tomography, Ann. Neurol. 21: 458–464.CrossRefGoogle Scholar
  26. Ochs, R.F., Gloor, P., Tyler, J.I., Wolfson, T., Worsley, K., Andermann, F., Diksic, M., Meyer, E., Evans, A., 1988, Metabolic correlates of diffuse EEG spike-and-wave and absence seizures. Reply, Ann. Neurol. 23: 207–208 (Letter).CrossRefGoogle Scholar
  27. Snead, O.C., 1978, Gamma hydroxybutyrate in the monkey: III. Effects of intravenous anticonvulsant drugs, Neurology 28: 1173–1178.Google Scholar
  28. Theodore, W.H., Newmark, M.E., Sato, S., De La Paz, R., DiChiro, G., Brooks, R., Patronas, N., Kessler, R.M., Anning, R., Margolin, R., Channing, M., and Porter, R.J., 1984, 18F-Fluorodeoxyglucose positron emission tomography in refractory complex partial seizures, Ann. Neurol. 14: 429–437.CrossRefGoogle Scholar
  29. Theodore, W.H., Brooks, R., Margolin, R., Patronas, N., Sato, S., Porter, R.J., Mansi, L., Bairamian, D., and DiChiro, G., 1985, Positron emission tomography in generalized seizures, Neurology 35: 684–690.Google Scholar
  30. Theodore, W.H., Rose, D., Patronas, N., Sato, S., Holmes, M., Bairamian, D., Porter, R.J., DiChiro, G., Larson, S., and Fishbein, D., 1987, Cerebral glucose metabolism in the Lennox-Gastaut syndrome, Ann. Neurol. 21: 14–21.CrossRefGoogle Scholar
  31. Vergnes, M., Marescaux, C., Micheletti, G., Reis, J., Depaulis, A., Rumbach, L. and Warter, J.M., 1982, Spontaneous paroxysmal electroclinical patterns in rat: a model of generalized non-convulsive epilepsy, Neurosci. Lett. 33: 97–101.CrossRefGoogle Scholar
  32. Wolfson, L.I., Sakurada, O., and Sokoloff, L., 1977, Effects of γ-butyrolactone on local cerebral glucose utilization in the rat, J. Neurochem. 29: 777–783.CrossRefGoogle Scholar
  33. Yamamoto, Y.L., Ochs, R., Gloor, P., Ammann, W., Meyer, E., Evans, A.C., Cooke, B., Sako, K., Gotman, J., Eindel, W.H., Diksic, M., Thompson, C.J., and Robitaille, Y., 1983, Patterns of rCBF and focal energy metabolic changes in relation to electroencephalographic abnormality in the inter-ictal phase of partial epilepsy, in: Current Problems in Epilepsy: I. Cerebral Blood Flow, Metabolism and Epilepsy (M. Baldy-Moulinier, D.-H. Ingvar, and B.S. Meldrum, eds.), John Libbey Eurotext, London, pp. 51–62.Google Scholar

Copyright information

© Birkhäuser Boston, Inc. 1990

Authors and Affiliations

  • J. EngelJr.
  • R. F. Ochs
  • P. Gloor

There are no affiliations available

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