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Spontaneous Spike-and-Wave Discharges in Wistar Rats: A Model of Genetic Generalized Nonconvulsive Epilepsy

  • M. Vergnes
  • Ch. Marescaux
  • A. Depaulis
  • G. Micheletti
  • J.-M. Warter

Abstract

The spontaneous occurrence of rhythmic par-oxystic discharges on the cortical EEG of rodents, especially in laboratory rats, has been described by many authors. Libouban and Oswaldo-Cruz (1958) first described such patterns, which they related to facial twitching in albino rats. Klingberg and Pickenhain (1968) studied these discharges and found that 20% of their rats presented with “Spindelent-ladungen.” These large “spindle” discharges (7 to 10 cps) were predominant in the frontal cortex and occurred in awake, but quiet animals. They could be elicited by a simple electrical shock applied to the thalamus (Kohler and Klingberg, 1969). These authors considered this phenomenon as borderline between a physiological and pathological activity. Vanderwolf described a similar EEG activity in some rats (Whishaw and Vanderwolf, 1971; Vanderwolf, 1975; Vanderwolf and Robinson, 1981).

Keywords

Corpus Callosum Cortical Spreading Depression Absence Seizure Absence Epilepsy Wave Discharge 
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© Birkhäuser Boston, Inc. 1990

Authors and Affiliations

  • M. Vergnes
  • Ch. Marescaux
  • A. Depaulis
  • G. Micheletti
  • J.-M. Warter

There are no affiliations available

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