Focal and Generalized Epileptiform Activity in the Cortex: In Search of Differences in Synaptic Mechanisms, Ionic Movements, and Long-Lasting Changes in Neuronal Excitability

  • M. Avoli
  • P. Gloor
  • G. Kostopoulos


The aim of this chapter is to compare the cellular and the ionic mechanisms that characterize the focal and generalized epileptiform discharges recorded in the cortex. In this review of experimental findings obtained in both in vivo and in vitro brain preparations, we have set as our goal understanding the differences that might exist at the cellular level in these epileptic patterns in humans.


GABAA Receptor Hippocampal Slice Epileptiform Discharge Convulsive Seizure Wave Discharge 
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© Birkhäuser Boston, Inc. 1990

Authors and Affiliations

  • M. Avoli
  • P. Gloor
  • G. Kostopoulos

There are no affiliations available

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