Anticonvulsant Effects of Intracortical Chronic Infusion of GABA in Generalized Epilepsy

  • S. Brailowsky
  • C. Silva-Barrat
  • Ch. Ménini
  • D. Riche
  • R. Naquet


The photosensitive baboon Papio papio affords a primate model of light-induced epilepsy in which intermittent light stimulation (ILS) induces the appearance of paroxysmal discharges (PD) and bilateral myoclonus (Killam et al., 1967). The electrophysiological characteristics of this model have been described (Menini’s chapter, this book), and here we will concentrate on, first, reviewing the pharmacological studies in the baboon that have employed drugs related to the GABAergic system; second, on describing our recent data using GABA itself in localized, chronic infusion, and, third, describing a new epileptogenic syndrome discovered in these animals at the end of GABA infusions: a GABA withdrawal syndrome.


Motor Cortex Anticonvulsant Effect Generalize Epilepsy Paroxysmal Activity Convulsant Effect 
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Copyright information

© Birkhäuser Boston, Inc. 1990

Authors and Affiliations

  • S. Brailowsky
  • C. Silva-Barrat
  • Ch. Ménini
  • D. Riche
  • R. Naquet

There are no affiliations available

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