Anhedonia as an Animal Model of Depression

  • George F. Koob


The clinical syndrome of depression is characterized by significant and long-term changes in mood and cognitive function. One of the most salient symptoms of a major depressive episode is a failure to obtain pleasure from activities that previously brought enjoyment (Klein, 1974). Recreational activities, sex, and eating now provide little or no gratification. The mood of the individual is characterized as depressed, sad, hopeless, and discouraged.


Major Depressive Episode Lateral Hypothalamus Inescapable Shock Medial Forebrain Bundle Dysphoric Mood 
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© Birkhäuser Boston 1989

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  • George F. Koob

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