Electrophysiology of the Locus Coeruleus: Implications for Stress-Induced Depression

  • Jay M. Weiss
  • Peter E. Simson


Exposing rats to uncontrollable shock produces behavioral and vegetative changes which bear considerable similarity to what is seen in human depression. This procedure represents the most widely studied animal model of psychopathology. As a result of this extensive study, similarity of the model to human depression has been shown with respect to etiology, symptomatology, and responsiveness to treatment. These similarities will now be reviewed briefly.


Firing Rate Locus Coeruleus Inescapable Shock Locus Coeruleus Neuron Spontaneous Firing Rate 
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© Birkhäuser Boston 1989

Authors and Affiliations

  • Jay M. Weiss
  • Peter E. Simson

There are no affiliations available

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