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The Neuropharmacology of Serotonin and Sleep: an Evaluation

  • John D. Fernstrom
  • Ross H. Pastel

Abstract

Depression is often associated with disruption of the normal sleep cycle. In particular, though patients frequently show disturbances in sleep continuity and a reduction in slow wave sleep, the most commonly observed effects are a shortened latency to the first episode of rapid eye movement (REM) sleep after sleep onset (i.e., a reduced REM latency), and an increase in REM density in the first REM periods during the night (Kupfer, 1982). The administration of antidepressant drugs typically suppresses most measures of REM sleep (see Kupfer, 1982), and it is an issue of general interest whether there is a connection between the pharmacologies of REM suppression and of antidepressant treatment. Several of the antidepressants in past, current, and experimental use are active at serotonin (5HT) synapses. The antidepressant action of such drugs is commonly thought to be associated with their ability to enhance transmission across 5HT synapses (see Willner, 1985). If this is the case and if there is a connection between a drug’s effects on sleep and depression, then these agents should have predictable actions on sleep, as should other drugs that affect 5HT synaptic function. The purpose of this review is to evaluate this latter proposition. To this end, a discussion is presented of the effects that each of several classes of agents that modify 5HT transmission has on sleep in mammals. These are broadly classed as agents that decrease or increase synaptic transmission.

Keywords

NREM Sleep NREM Sleep Time Cortical Slow Wave 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Further Reading

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Copyright information

© Birkhäuser Boston 1989

Authors and Affiliations

  • John D. Fernstrom
  • Ross H. Pastel

There are no affiliations available

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