Sensory Transduction, Small-Signal Analysis of
Applied mathematics is a mainstay of quantitative physiology—from the cable theory of the cell membrane to the cross-bridge theories relating macromolecular events and tension in muscle. A subset of this work has applied engineering transfer-function analysis or input-output analysis to the dynamic responses of sensory cells of several modalities. This approach involves close control of inputs such as light and mechanical deformation, and monitoring of output changes of generator potential and spike rate. Moreover, with small sinusoidal or step-like changes of such inputs, the differential equations describing the measured input-output dynamics are often nearly linear.
KeywordsSpike Rate Linear Transfer Function Sensory Transduction Cable Theory Tactile Spine
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