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Pain Management, Focal Instillation of Opiates in the Central Nervous System

  • Charles E. Poletti
Part of the Readings from the Encyclopedia of Neuroscience book series (REN)

Abstract

The use of implantable systems for the long-term focal delivery of pharmacologic agents to the central nervous system (CNS) represents a major therapeutic advance. These systems can now be used to deliver opiates, hormones, neurotransmitters, antibiotics, anticoagulants, oncolytic agents, and other compounds targeted to the epidural space, cerebrospinal fluid, neu-raxis, or bloodstream. In the management of pain states this approach has the advantage of avoiding both the systemic effects associated with high-dose narcotics and the problems associated with the surgical destruction of portions of the nervous system.

Keywords

Epidural Space Opiate Receptor Phantom Limb Pain Spinal Subarachnoid Space Spinal Morphine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further reading

  1. Cousin MJ, Mather LE (1984): Intrathecal and epidural administration of opioids. Anesthesiology 61:276–310CrossRefGoogle Scholar
  2. Poletti CE, Schmidek HH, Sweet WH, Pilon RN (1982): Pain control with implantable systems for the long-term infusion of intraspinal opioids in man. In: Operative Neurosurgical Techniques 2:1199–1210Google Scholar
  3. Yaksh TL (1981): Spinal opiate analgesia: characteristics and principle of action. Pain 11:293–346CrossRefGoogle Scholar

Copyright information

© Birkhäuser Boston, Inc. 1988

Authors and Affiliations

  • Charles E. Poletti

There are no affiliations available

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