Pain Management, Focal Instillation of Opiates in the Central Nervous System
The use of implantable systems for the long-term focal delivery of pharmacologic agents to the central nervous system (CNS) represents a major therapeutic advance. These systems can now be used to deliver opiates, hormones, neurotransmitters, antibiotics, anticoagulants, oncolytic agents, and other compounds targeted to the epidural space, cerebrospinal fluid, neu-raxis, or bloodstream. In the management of pain states this approach has the advantage of avoiding both the systemic effects associated with high-dose narcotics and the problems associated with the surgical destruction of portions of the nervous system.
KeywordsEpidural Space Opiate Receptor Phantom Limb Pain Spinal Subarachnoid Space Spinal Morphine
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