Artificial Sweeteners: Do They Live Up to Expectations?

  • Robin B. Kanarek
  • Robin Marks-Kaufman


Over the past decade, the taste of the American public for both gourmet fare and fast foods has increased exponentially. It is impossible to find a major metropolitan area, and difficult to find a smaller city, without a fancy food store or gourmet deli. Our desire for convenient fast foods is clearly evidenced by the rise of fast food chains throughout the country. During this same period, however, there has also been a striking increase in public concern about excess caloric intake and its possible consequences: obesity, heart disease, and diabetes. It has been proposed that low-calorie or artificial sweeteners may help to satisfy our twin cravings for palatable, convenient foods and slimness (Lecos 1985).


Caloric Intake Artificial Sweetener Plasma Amino Acid Snack Intake Calorie Sweetener 
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  1. Anderson, G. H., S. Saravis, R. Schacher, S. Zlotkin, and L. A. Leiter. 1989. Aspartame: Effect on lunch-time food intake, appetite and hedonic response in children. Appetite 13: 93–103.CrossRefGoogle Scholar
  2. Anonymous. 1988. Acesulfame-K: A new artificial sweetener. The Medical Letter p. 116.Google Scholar
  3. Birch, L. L., L. McPhee, and S. Sullivan. 1989. Children’s food intake following drinks sweetened with sucrose or aspartame: Time course effects. Physiology and Behavior 45 (2): 387–395.CrossRefGoogle Scholar
  4. Blundell, J. E. and A. J. Hill. 1986. Paradoxical effects of an intense sweetener (aspartame) on appetite. Lancet 1: 1092–1093.CrossRefGoogle Scholar
  5. Blundell, J. E. and A. J. Hill. 1987. Artificial sweeteners and the control of appetite: Implications for the eating disorders. In The Future of Predictive Safety Evaluation, vol. 2, ed. A. Worden, D. Parke, and J. Marks, pp. 263–282. Lancas¬ter, England: MTP Press.CrossRefGoogle Scholar
  6. Blundell, J. E., P. J. Rogers, and A. J. Hill. 1988. Uncoupling sweetness and calories: Methodological aspects of laboratory studies on appetite control. Appetite 11 (Suppl): 54–61.Google Scholar
  7. Bradstock, M. K., M. K. Serdula, J. S. Marks, R. J. Barnard, N. T. Crane, P. L. Remington, and F. L. Trowbridge. 1986. Evaluation of reactions to food additives: The aspartame experience. American Journal of Clinical Nutrition 43: 464–469.Google Scholar
  8. Bray, G. A. 1987. Overweight is risking fate. Definition, classification, prevalence, and risks. Annals of the New York Academy of Sciences 499: 14–28.CrossRefGoogle Scholar
  9. Calorie Control Council. 1988. “A Review of Low-Calorie Sweetener Benefits.” Atlanta, GA: Calorie Control Council.Google Scholar
  10. Cooper, J. R, F. E. Bloom, and R. H. Roth. 1986. The Biochemical Basis of Neuropharmacology. New York: Oxford University Press.Google Scholar
  11. Council on Scientific Affairs. 1985. Aspartame: Review of safety issues. Journal of the American Medical Association 254 (3): 400–402.CrossRefGoogle Scholar
  12. Federal Register. 1981. Aspartame: Commissioner’s final decision. 46 (142): 38285–38299.Google Scholar
  13. Filer, L. J. and L. D. Stegink. 1989. Aspartame metabolism in normal adults, phenylketonuric heterozygotes, and diabetic subjects. Diabetes Care 12 (1): 67 — 74.CrossRefGoogle Scholar
  14. Franz, M. 1986. Is it safe to consume aspartame during pregnancy? A review. The Diabetes Educator 12 (2): 145–148.CrossRefGoogle Scholar
  15. Kanarek, R. B., N. Orthen-Gambill, R. Marks-Kaufman, and J. Mayer. 1984. Obesity: Possible psychological and metabolic determinants. In Nutrition and Behavior, ed. Janina Galler, pp. 339–396. New York: Plenum.Google Scholar
  16. Kanders, B. S., P. T. Lavin, M. B. Kowalchuk, I. Greenberg, and G. L. Black¬burn. 1988. The effect of artificial sweeteners (aspartame) on weight loss, dietary compliance and quality of life. Appetite 11 (Suppl.): 73–84.Google Scholar
  17. Lapierre, K. A., D. J. Greenblatt, J. E. Goddard, J. S. Harmatz and R. I. Shader. 1990. The Neuropsychiatry effects of aspartame in normal volunteers. Journal of Clinical Pharmacology 30: 454–460.Google Scholar
  18. Lecos, C. W. 1985. Sweetness minus calories = controversy. FDA Consumer, February: 18–23.Google Scholar
  19. Leon, A. S., D. B. Hunninghake, C. Bell, D. K. Rassin, and T. R. Tephly. 1989. Safety of long-term large doses of aspartame. Archives of Internal Medicine 149: 2318–2324.CrossRefGoogle Scholar
  20. Levy, H. L. and S. E. Waisbren. 1987. The PKU paradigm: The mixed results from early dietary treatment. In Amino Acids in Health and Disease: New Perspectives, ed. S. Kaufman, pp. 539–551. New York: Alan R. Liss.Google Scholar
  21. Mattes, R. 1990. Effects of aspartame and sucrose on hunger and energy intake in humans. Physiology and Behavior 47: 1037–1044.CrossRefGoogle Scholar
  22. Mazur, R. H. 1984. Discovery of aspartame. In Asparatame, ed. L. D. Stegink and L. J. Filer, pp. 3–7. New York: Marcel Dekker.Google Scholar
  23. Miller, S. A. and V. P. Frattali 1989. Saccharin. Diabetes Care 12 (l): 75–80.CrossRefGoogle Scholar
  24. National Research Council. 1985. Evaluation of Cyclamate for Carcinogenicity. Washington, DC: National Academy Press.Google Scholar
  25. Olney, J. W. 1976a. Brain damage and oral intake of certain amino acids. Advances in Experimental Biology and Medicine 69: 497–507.Google Scholar
  26. Olney, J. W. 1976b. L-glutamic and L-aspartic acids: A question of hazard? Food and Cosmetic Toxicology 13: 595–596.CrossRefGoogle Scholar
  27. Pardridge, W. M. 1986. Potential effects of the dipeptide sweetener aspartame on the brain. In Nutrition and the Brain, vol. 7, ed. R. J. Wurtman and J. J. Wurtman, pp. 199–241. New York: Raven Press.Google Scholar
  28. Porikos, K. P., G. Booth, and T. B. Van Itallie. 1977. Effect of covert nutritive dilution on the spontaneous food intake of obese individuals: A pilot study. American Journal of Clinical Nutrition 30: 1638–1644.Google Scholar
  29. Porikos, K. P., M. F. Hesser, and T. B. Van Itallie. 1982. Caloric regulation in normal weight men maintained on a palatable diet of conventional foods. Physiology and Behavior 29: 293–300.CrossRefGoogle Scholar
  30. Reynolds, W. A., V. Butler, and N. Lemkey-Johnston. 1976. Hypothalamic mor-phology following ingestion of aspartame or MSG in the neonatal rodent and primate: A preliminary report. Journal of Toxicology and Environmental Health 2: 471–480.CrossRefGoogle Scholar
  31. Rogers, P. J. and J. E. Blundell. 1989. Separating the actions of sweetness and calories: Effects of saccharin and carbohydrates on hunger and food intake in human subjects. Physiology and Behavior 45: 1093–1099.CrossRefGoogle Scholar
  32. Rogers, P. J., J. Carlyle, A. J. Hill, and J. E. Blundell. 1988. Uncoupling sweet taste and calories: Comparison of the effects of glucose and three intense sweeteners on hunger and food intake. Physiology and Behavior 43 (5): 547–552.CrossRefGoogle Scholar
  33. Rogers, P. J., H. C. Pleming, and J. E. Blundell. 1990. Aspartame ingested without tasting inhibits hunger and food intake. Physiology and Behavior 47: 1239–1243.CrossRefGoogle Scholar
  34. Rolls, B. J., S. Kim, and I. C. Fedoroff. 1990. Effects of drinks sweetened with sucrose or aspartame on hunger, thirst and food intake in men. Physiology and Behavior 48: 19–26.CrossRefGoogle Scholar
  35. Schiffman, S. S., C. E. Buckley, III, H. A. Sampson, E. W. Massey, J. N. Baraniuk, J. V. Follett, and Z. S. Warwick. 1987. Aspartame and suceptibility to headache. New England Journal of Medicine 317 (19): 1181–1185.CrossRefGoogle Scholar
  36. Spreen, O., D. Tupper, A. Risser, H. Tuokko, and D. Edgell. 1984. Human Developmental Neuropsychology. New York: Oxford University Press.Google Scholar
  37. Stegink, L. D. 1987. The aspartame story: A model for the clinical testing of a food additive. American Journal of Clinical Nutrition 46: 204–215.Google Scholar
  38. Stegink, L. D., L. J. Filer, and G. L. Baker. 1987. Plasma amino acid concentra¬tions in normal adults ingesting aspartame and monosodium L-glutamate as part of a soup/beverage meal. Metabolism 36: 1073–1079.CrossRefGoogle Scholar
  39. Stegink, L. D., L. J. Filer, and G. L. Baker. 1988. Repeated ingestion of aspartame-sweetened beverage: Effect on plasma amino acid concentrations in normal adults. Metabolism 37 (3): 246–251.CrossRefGoogle Scholar
  40. Tordoff, M. G. and A. M. Alleva. 1990. Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight. American Journal of Clinical Nutrition 51: 963–968.Google Scholar
  41. Vander, Arthur J. 1981. Nutrition, Stress, and Toxic Chemicals. Ann Arbor: University of Michigan Press.Google Scholar
  42. Van Itallie, T. B., M.-U. Yang, and K. P. Porikos. 1988. Use of aspartame to test the body weight set point hypothesis. Appetite 11 (Suppl.): 68–72.CrossRefGoogle Scholar
  43. Wolf-Novak, L. C., L. D. Stegink, M. C. Brummel, T. J. Persoon, L. J. Flier, E. F. Bell, E. E. Ziegler, and W. L. Krause. 1990. Aspartame ingestion with and without carbohydrate in phenylketonuric and normal subjects: Effect on plasma concentra-tions of amino acids, glucose, and insulin. Metabolism 39: 391–396.CrossRefGoogle Scholar

Copyright information

© Van Nostrand Reinhold 1991

Authors and Affiliations

  • Robin B. Kanarek
    • 1
  • Robin Marks-Kaufman
    • 1
  1. 1.Tufts UniversityMedfordUSA

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