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Physiological Effects of Monounsaturated Oils

  • Gene A. Spiller

Abstract

Early investigation into the effects of diet on serum cholesterol showed that vegetable oils were hypocholesterolemic when substituted for saturated fatty acids. Subsequent work by many investigators seemed to indicate that polyunsaturated fats (PFAs) were cholesterol-lowering, saturated fats (SFAs) were cholesterol-raising, and monounsaturated fats (MFAs) were neutral. Linoleic acid became the polyunsaturated fat of choice. The conclusions of these studies gained wide acceptance in the medical and scientific world. For nearly two decades following this early work, research on the connection between diet and coronary heart disease was focused almost exclusively on the ratio of polyunsaturated to saturated fats (expressed as the PIS ratio), with MFAs receiving little attention.

Keywords

Linoleic Acid High Density Lipoprotein Cholesterol Total Serum Cholesterol Mediterranean Diet Monounsaturated Fatty Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aravanis, C., R. P. Mensink, N. Karalias, B. Christodoulou, A. Kafatos, and M. B. Katan. 1988. Serum lipids, apoproteins and nutrient intake in rural Cretan boys consuming high olive oil diets. J. Clin. Epidemiol. 41:1117–1123.PubMedCrossRefGoogle Scholar
  2. Baggio, G., A. Pagnan, M. Muraca, S. Martini, A. Opportuno, A. Bonanome, G. B. Ambrosio, S. Ferrari, P. Guarini, and D. Piccolo. 1988. Olive-oilenriched diet: effect on serum lipoprotein levels and biliary cholesterol saturation. Am. J. Clin. Nutr. 47(6):960–964.PubMedGoogle Scholar
  3. Bailey, A. E. 1951. Industrial Oil and Fat Products. New York: Interscience.Google Scholar
  4. Dreon, G. A., K. M. Vranizan, R. M. Krauss, M. A. Austin, and P. Wood. 1990. The effects of polyunsaturated fat vs monounsaturated fat on plasma lipoproteins. JAMA 263:2462–2466.PubMedCrossRefGoogle Scholar
  5. Gammal, E. B., K. K. Carroll, and E. R. Plunkett. 1967. Effect of dietary fat on mammary carcinogenesis by 7,12-dimethylbenz(alpha)anthracene in rats. Cancer Res. 27:1737–1742.PubMedGoogle Scholar
  6. Garg, A., A. Bonanome, S. M. Grundy, Z. J. Zhang, and. R. H. Unger. 1988. Comparison of a high-carbohydrate diet with a high-monounsaturated-fat diet in patients with non-insulin-dependent diabetes mellitus. New Engl. J. Med. 319:829–834.PubMedCrossRefGoogle Scholar
  7. Ginsberg, H. N., S. L. Barr, A. Gilbert, W. Karmally, R. Deckelbaum, K. Kaplan, R. Ramakrishnan, S. Holleran, and R. B. Dell. 1990. Reduction of plasma cholesterol levels in normal men on an American Heart Association Step 1 diet or a Step 1 diet with added monounsaturated fat. New Engl. J. Med. 322(9):574–579.PubMedCrossRefGoogle Scholar
  8. Grundy, S. M. 1986. Comparison of monounsaturated fatty acids and carbohy- drates for lowering plasma cholesterol. New Engl. J. Med. 314(12):745–748.PubMedCrossRefGoogle Scholar
  9. Grundy, S. M. 1987. Monounsaturated fatty acids, plasma cholesterol, and coronary heart disease. Am. J. Clin. Nutr. 45(suppl. 5):1168–1175.PubMedGoogle Scholar
  10. Grundy, S. M., L. Florentin, D. Nix, and M. F. Whelan. 1988. Comparison of monounsaturated fatty acids and carbohydrates for reducing raised levels of plasma cholesterol in man. Am. J. Clin. Nutr. 47(6):965–969.PubMedGoogle Scholar
  11. Keys, A. 1980. Seven Countries. A Multivariate Analysis of Death and Coronary Heart Disease. Cambridge, Mass.: Harvard University Press.Google Scholar
  12. McDonald, B. F., J. M. Gerrad, V. M. Bruce, and E. J. Corner. 1990. Comparison of the effects of canola oil and sunflower oil on plasma lipids and lipoproteins and on in vivo tromboxane A2 and prostacyclin production in healthy young men. Am. J. Clin. Nutr. 50:1382–1388.Google Scholar
  13. Mattson, F. H., and S. M. Grundy. 1985. Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J. Lipid Res. 26:194–202.PubMedGoogle Scholar
  14. Mensink, R. P., and M. B. Katan. 1987. Effect of monounsaturated fatty, acids versus complex carbohydrates on high-density lipoproteins in healthy men and women. Lancet 1(8525):122–125.PubMedCrossRefGoogle Scholar
  15. Mensink, R. P., and M. B. Katan. 1989. Effect of a diet enriched with monounsaturated or polyunsaturated fatty acids on levels of low-density and high-density lipoprotein cholesterol in healthy women and men. New Engl. J. Med. 321(7): 436–441.PubMedCrossRefGoogle Scholar
  16. Mensink, R. P., M. J. de Groot, L. T. van den Broeke, A. P. Severijnen-Nobels, P. N. Demacker, and M. B. Katan. 1989. Effects of monounsaturated fatty acids v. complex carbohydrates on serum lipoproteins and apoproteins in healthy men and women. Metabolism 38(2):172–178.PubMedCrossRefGoogle Scholar
  17. Spiller, G. A., J. E. Gates, D. J. A. Jenkins, O. Bosello, S. F. Nichols, and L. Cragen. 1990. Effect of two foods high in monounsaturated fat on plasma cholesterol and lipoproteins in adult humans. Am. J. Clin. Nutr. 51(3):524.Google Scholar
  18. Spiller, G. A., D. J. A. Jenkins, L. Cragen, O. Bosello, K. Berra, C. Rudd, and R. Superko. 1989. Sustained reductions of serum cholesterol over nine weeks on a diet with a high ratio of monounsaturated fats to other fats (Abstract). X Internat. Symp. Drugs Affecting Lipid Metabolism, Houston, Tex.Google Scholar
  19. Trevisan, M., V. Krogh, J. Freudenheim, A. Blake, P. P. S. Muti, E. Farinaro, M. Mancini, A. Menotti, and G. Ricci. 1990. Consumption of olive oil, butter, and vegetable oils and coronary heart disease risk factors. JAMA 263(5):688–692.PubMedCrossRefGoogle Scholar

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© Van Nostrand Reinhold 1991

Authors and Affiliations

  • Gene A. Spiller

There are no affiliations available

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