Intragenomic Hierarchies of DNA Damage Recognition

  • Hanspeter Naegeli
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Nuclear DNA in mammalian cells is a highly nonuniform substrate with respect to its susceptibility to genotoxic reactions. For example, cyclobutane pyrimidine dimer formation is modulated at the nucleosomal level with a 10.3 base average periodicity.1,2 The frequency of pyrimidine(6-4)pyrimidone photoproducts is greater in nuclease-sensitive DNA than in nuclease-resistant fractions of chromatin.3 Binding of transcription factors may either enhance or suppress photoproduct formation within active genes.4 Similarly, the distribution of DNA adducts formed by chemical reagents is dependent on the protein environment and the nucleotide sequence context.5–7

Keywords

Adduct Compaction Glucocorticoid Lactose Leucine 

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© R.G. Landes Company 1997

Authors and Affiliations

  • Hanspeter Naegeli
    • 1
  1. 1.Institute of Pharmacology and ToxicologyUniversity of Zürich-TierspitalZürichSwitzerland

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