Neurologic Complications of Infectious Mononucleosis

  • Charles Grose
Part of the Clinical Topics in Infectious Disease book series (CLIN.TOP.INFECT)


The neurologic manifestations of infectious mononucleosis (IM) were first recognized over 50 years ago (Johansen 1931; Epstein and Dameshek 1931) and probably occur in 1 to 5 percent of children and adults with primary Epstein-Barr virus (EBV) infections (Bernstein and Wolff 1950; Hoagland 1967; Silverstein, Steinberg, and Nathanson 1972). The neurologic symptoms and signs usually appear concomitantly with or follow overt IM (Bernstein and Wolff 1950); less commonly, they precede IM or are the only clinically apparent sequelae of EBV infection (Silverstein, Steinberg, and Nathanson). In this chapter, I will first present a likely schema of the pathogenesis of IM, including the neurologic disease; then I will describe the varied clinical presentations of IM-associated neurologic syndromes; finally I will discuss diagnosis and management of the patient. In the last regard, magnetic resonance imaging represents a major advance in the early diagnosis of EBV involvement of the brain.


Neurologic Disease Infectious Mononucleosis Herpes Simplex Encephalitis Barre Syndrome Peripheral Neuritis 
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  • Charles Grose

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