Infectious Mononucleosis: The Classic Clinical Syndrome

  • Paul A. Chervenick
Part of the Clinical Topics in Infectious Disease book series (CLIN.TOP.INFECT)


Infectious mononucleosis is primarily a disease of the adolescent and young adult, and in this age group the clinical manifestations are characteristic and uniform in nature but vary in severity. The disease is caused by the Epstein-Barr virus and is characterized clinically by fever, pharyngitis, lymphadenopathy, and splenomegaly and by laboratory findings of lymphocytosis, atypical lymphocytes in the blood, and the presence of heterophile antibody and various antibodies specific for the Epstein-Barr virus. These findings have been described in a number of reviews (Hoagland 1967; Finch 1969; Chervenick 1974, 1983; Karzon 1976; Schleupner and Overall 1979; Chang 1980, Schlossberg 1983). Similar clinical findings may be seen in patients with a heterophile-negative mononucleosis-like illness, most notably cytomegalovirus infection, toxoplasmosis, or infection with human immunodeficiency virus (Steeper et al. 1988).


Sore Throat Cranial Nerve Palsy Infectious Mononucleosis Erythema Multiforme Organ System Involvement 
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© Springer-Verlag New York Inc. 1989

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  • Paul A. Chervenick

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