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Infectious Mononucleosis Epidemiology and Pathogenesis

  • Stephen E. Straus
  • Gary R. Fleisher
Part of the Clinical Topics in Infectious Disease book series (CLIN.TOP.INFECT)

Abstract

The earliest reports of illnesses resembling acute infectious mononucleosis (IM) appeared in the last two decades of the nineteenth century, but it was not until 1920 that the syndrome as we currently know it was described. The apparent lack of prior recognition of IM rests not on oversight but rather on the infrequency of this disease.

Keywords

Acquire Immune Deficiency Syndrome Infectious Mononucleosis Oral Secretion Military Academy Heterophile Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Albeck, H., et al. (1985). Epstein-Barr virus infection and serological profile in Greenland Eskimo children. Acta Fed. Scand. 74:691–696.Google Scholar
  2. Andersson, J., et al. (1986). Effect of Acyclovir on infectious mononucleosis. J. Infect. Dis. 153: 283–290.PubMedGoogle Scholar
  3. Baehner, R. L., and Shuler, S. E. (1967). Infectious mononucleosis in children.Clin. Fed. 6:393.Google Scholar
  4. Bang, J. (1942). Experiments with the transfer of infectious mononucleosis to monkeys—with negative results. Acta Med. Scand. 111:291.Google Scholar
  5. Bang, J. (1943). Experiments with the transfer of infectious mononucleosis to man. Acta Med. Scand. 123:304.Google Scholar
  6. Belfrage, S. (1962). Infectious mononucleosis: An epidemiological and clinical study. Acta Med. Scand. 171:531.PubMedGoogle Scholar
  7. Biggar, R.J., Henle, G., Bocker, J., et al. (1978). Primary Epstein-Barr virus infections in African infants. II. Clinical and serological observations during seroconversion. Int. J. Cancer 22:244.PubMedGoogle Scholar
  8. Biggar, R.J., Henle, W., Heisher, G.R., et al. (1978). Primary Epstein-Barr virus infections in African infants. I. Decline of maternal antibodies and time of infection.Int. J. Cancer 22:239.PubMedGoogle Scholar
  9. Black, F. L., Woodall, J. P., Evans, A. S., et al. (1970). Prevalence of antibody against viruses in the Tir- iyo, an isolated Amazon tribe. Am. J. Epidemiol. 91:430.PubMedGoogle Scholar
  10. Blacklow, N.R., Watson, B.R., Miller, G., et al. (1971). Mononucleosis with heterophil antibodies in EB virus infection: Acquisition by an elderly patient in hospital.Am. J. Med. 51:549.PubMedGoogle Scholar
  11. Bland, J.O.W. (1931). Discussion on glandular fever. Froc. Roy. Soc. Med 25:155.Google Scholar
  12. Bums, J.E. (1909). Glandular fever: Report of an epidemic in the children’s ward of Union Protestant Infirmary. Arch. Intern. Med. 4:118.Google Scholar
  13. Chang, R.S. (1975). Interpersonal transmission of EB-vinis infection. N. Engl. J. Med. 293:454.PubMedGoogle Scholar
  14. Chang, R.S., and Golden, H.D. (1971). Transformation of human leucocytes by throat washing from infectious mononucleosis patients. Nature 234:359.PubMedGoogle Scholar
  15. Chang, R.S., Lewis, J.P., and Abildgaard, C.E. (1973). Prevalence of oropharyngeal excreters of leukocyte transforming agents among a human population. N. Engl. J. Med. 289:1325.PubMedGoogle Scholar
  16. Chang, R.S., Lewis, J.S., Reynolds, R.D. et al. (1978). Oropharyngeal excretion of Epstein-Barr virus by patients with lymphoproliferative disorders and by recipients of renal homografts. Ann. Intern. Med. 88:34.PubMedGoogle Scholar
  17. Christine, B.W. (1968). Infectious mononucleosis. Conn. Health Bull. 82:115.Google Scholar
  18. Davidsohn, I. (1937). Serologic diagnosis of infectious mononucleosis.JAMA 108:289.Google Scholar
  19. Davidsohn, R. J. L. (1970). A survey of infectious mononucleosis in the North-East Regional Hospital Board area of Scotland, 1960–1969.J. Hyg. (Camb.) 68:393.Google Scholar
  20. Davis, C.M. (1929). Acute glandular fever of Pfeiffer: Report of a nursery epidemic. JAMA 92:1417.Google Scholar
  21. Demissie, A., and Svedmyr, A. (1969). Age distribution of antibodies to EB virus in Swedish females as studied by indirect immunofluorescence on Burkitt cells. Acta Fathol. Microbiol. Scand. 75:457.Google Scholar
  22. Downey, A., and McKinlay, C.A. (1923). Acute lymphadenosis compared with acute lymphatic leukemia. Arch. Intern. Med. 32: 82–112.Google Scholar
  23. Enberg, R.N., Eberle, B.J., and Williams, R.C. (1974). T and B cells in peripheral blood during infectious mononucleosis. J. Infect. Dis. 130:103–111.Google Scholar
  24. Epstein, M.A., Achong, B.G., and Barr, M. (1964). Virus, particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 1:702–703.PubMedGoogle Scholar
  25. Evans, A.S. (1947). Experimental attempts to transmit infectious mononucleosis to man. Yale J. Biol Med. 20:19.PubMedGoogle Scholar
  26. Evans, A.S. (1950). Further experimental attempts to transmit infectious mononucleosis to man. J. Clin. Invest. 29:508.PubMedGoogle Scholar
  27. Evans, A.S. (1960). Infectious mononucleosis in University of Wisconsin students: Report of a 5-year investigation. Am. J. Hyg. 71:342.PubMedGoogle Scholar
  28. Evans, A.S. (1969). Infectious mononucleosis: Recent developments. Gen. Pract. 60:127.Google Scholar
  29. Evans, A.S. (1970). Infectious mononucleosis in the Armed Forces. Milit. Med. 135:300.Google Scholar
  30. Evans, A.S. (1981). Epidemiology of Epstein-Barr virus infection and disease. In A.J. Nahmias et al. (eds.). The Human Herpesviruses, New York, Elsevier, p. 172.Google Scholar
  31. Evans, A.S., Evans, B.K., and Sturtz, U. (1953). Standards for hepatic and hematologic tests in monkeys: Observations during experiments with hepatitis and mononucleosis. Proc. Soc. Exp. Biol. Med. 82:437.PubMedGoogle Scholar
  32. Evans, A.S., and Robinton, E.D. (1950). An epidemiologic study of infectious mononucleosis. N. Engl. J. Med 242:492–496.Google Scholar
  33. Filatov, N.F. (1985) Lektuse ob ostrikh infektsion Nikh Lolieznyak (Lectures on acute infectious diseases of children), Moscow, U Deitel, cited by Wising, P.J., Acta Med. Scand. Suppl. 133:1–102 (1942).Google Scholar
  34. Reisher, G., and Bolognese, R. (1984). Epstein-Barr virus in pregnancy: A prospective study. J. Ped. 104:374.Google Scholar
  35. Reisher, G., Henle, W., Henle, G., et al. (1979b). Primary infection with Epstein-Barr virus in infants in the United States: Clinical and serological observations.J. Infect. Dis. 139:553.Google Scholar
  36. Reisher, G.R., Lennette, E.T., Henle, G., et al. (1979a). Incidence of heterophile-antibody responses in children with infectious mononucleosis.J Ped 94:723.Google Scholar
  37. Reisher, G.R., Paradise, J.E., and Lennette, E.T. (1981b). Leukocyte response in childhood infectious mononucleosis caused by Epstein-Barr virus. Am. J. Dis. Child 135:699.Google Scholar
  38. Reisher, G.R., Pasquariello, P.S., Warren, W.S., et al. (1981a). Intrafamilial transmission of Epstein-Barr virus infections. J. Ped. 98:16.Google Scholar
  39. Gachet, F.S., and Price, W.C., (1954). Infectious mononucleosis in infants and children. J. Florida Med. Assoc. 41:280.Google Scholar
  40. Gamer, J.S., and Simmons, B.P. (eds.) (1983). CDC guidelines for Isolation precautions in Hospitals. Infect. Control 4 (Suppl.):245.Google Scholar
  41. Gerber, P., Lucas, S., Nonoyama, M., et al. (1972). Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis. Lancet 2:988.PubMedGoogle Scholar
  42. Gerber, P., Walsh, J.H., Rosenblum, E.N., et al. (1969). Association of EB-virus infection with the post-perfusion syndrome. Lancet 1:593.PubMedGoogle Scholar
  43. Ginsberg, C.M., Henle, G., and Henle, W. (1976). An outbreak of infectious mononucleosis among the personnel of an outpatient clinic. Am. J. Epidemiol. 104:571.Google Scholar
  44. Ginsburg, C.M., Henle, W., Henle, G., et al. (1977). Infectious mononucleosis in children: Evaluation of Epstein-Barr virus-specific serology. JAMA 237:781.PubMedGoogle Scholar
  45. Golden, H.D., Chang, R.S., Prescott, W., et al. (1973). Leukocyte transforming agent: Prolonged excretion by patients with mononucleosis and excretion by normal individuals. J. Infect. Dis. 127:471.PubMedGoogle Scholar
  46. Golubjatnikov, R., Allen, V.D., Steadman, S., et al. (1973) Prevalence of antibodies to Epstein-Barr virus, cytomegalovirus and toxoplasma in a Mexican highland community.Am. J. Epidemiol. 97:116.PubMedGoogle Scholar
  47. Goode, R. L., and Coursey, D. L. (1976). Tonsillectomy and infectious mononucleosis—a possible relationship. Laryngoscope 87:992.Google Scholar
  48. Guthrie, C.D., and Pessel, J.E. (1925). An epidemic of “glandular fever” in a preparatory school for boys. Am. J. Med Sei. 29:492.Google Scholar
  49. Halcrow, J.P.A., Owen, L.M., Rodger, N.O. (1943). Infectious mononucleosis with an account of an epidemic in an E.M.S. Hospital. Br. Med. J. 2:443.PubMedGoogle Scholar
  50. Hallee, T.J., Evans, A.S., Niederman, J.C., et al. (1974) Infectious mononucleosis at the United States Military Academy. Yale J. Biol. Med. 47:182.PubMedGoogle Scholar
  51. Hanto, D.W., Frizzera, G., Purtilo, D.T., et al. (1981). Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Can. Res. 41:4253.Google Scholar
  52. Haynes, B.F, Schooley, R.T., Payling-Wright, C.R., et al. (1979). Emergence of suppressor cells of immunoglobulin synthesis during acute Epstein-Barr virus-induced infectious mononucleosis. J. Immunol. 123:2095.PubMedGoogle Scholar
  53. Heath, C. W., Brodsky, A. L., and Potolsky, A. L. (1972). Infectious mononucleosis in a general population. Am. J. Epidemiol. 95:46.PubMedGoogle Scholar
  54. Henke, G.E., Kurland, L.T., and Elveback, L.R. (1973). Infectious mononucleosis in Rochester, Minn, 1950 through 1969. Am. J. Epidemiol. 98:483.PubMedGoogle Scholar
  55. Henle, G., and Henle, W. (1967). Immunofluorescence, interference and complement fixation techniques in the detection of herpes types virus in Burkitt tumor cell lines. Cancer Res. 27:2442.PubMedGoogle Scholar
  56. Henle, G., and Henle, W. (1970). Observations on childhood infections with the Epstein-Barr virus. J. Infect Dis. 121:303.PubMedGoogle Scholar
  57. Henle, G., Henle, W., Clifford, P., et al. (1969). Antibodies to Epstein-Barr virus in Burkitt’s lymphoma and control groups. J. Natl Cancer Inst. 43:1147.PubMedGoogle Scholar
  58. Henle, G., Henle, W., and Diehl, V. (1968). Relation of Burkitt’s tumor associated herpes-type virus to infectious mononucleosis. Proc. Natl Acad. Sei. (USA) 59:94Google Scholar
  59. Hoagland, RJ. (1955). The transmission of infectious mononucleosis. Am. J. Med. Sei. 229:262.Google Scholar
  60. Hobson, E.G., Lawson, B., and Wigfield, M. (1958). Glandular fever: A field study. Brit. Med. J. 1:845.PubMedGoogle Scholar
  61. Holswade, G.R., Engle, M.A., Redo, S.F., et al. (1963). Development of viral diseases and a viral- disease-Uke syndrome after extra-corporeal circulation. Cireulation 27:812.Google Scholar
  62. Horwitz, C., Henle, W., Henle, G., et al. (1981). Clinical and laboratory evaluation of infants and children with EBV-induced infectious mononucleosis. Blood 57:433.Google Scholar
  63. Horwitz, C.A., Henle, W., Henle, G., et al. (1976). Clinical and laboratory evaluation of elderly patients with heterophile-antibody positive infectious mononucleosis.Am. J. Med. 61:333.PubMedGoogle Scholar
  64. Horwitz, C.A., Henle, W., Henle, G., et al. (1983). Infectious mononucleosis in patients aged 40 to 72 years: Report 27 cases, including 3 without rhetero- phil-antibody responses. Medicine 62:256–262.PubMedGoogle Scholar
  65. Joncas, J., and Mitnyan, C. (1970). Serologic response of the EBV antibodies in pediatric cases on infectious mononucleosis and their contacts. Can. Med. Assoc. J. 102:1260.PubMedGoogle Scholar
  66. Julianelle, J.A., Bierbaum, O.S., and Moore, C.V. (1944). Studies on infectious mononucleosis. Ann. Intern. Med. 20:281.Google Scholar
  67. Kafuko, G.W., Henderson, B.E., Kirya, B.G., et al. (1972). Epstein-Barr virus antibody levels in children from the west Nile District of Uganda. Lancet 1:706.PubMedGoogle Scholar
  68. Kreel, I., Zaroff, L.I., Carter, J.W., et al. (1960). A syndrome following total body perfusion. Surg. Gyn. Obst. 111:317.PubMedGoogle Scholar
  69. Lamy, M.E., Favart, A.M., Comue, C., et al. (1982). Study of Epstein-Barr virus (EBV) antibodies. Acta Clin. Belg. 37:5.Google Scholar
  70. Lang, D.J., Garruto, R.M., and Gajdusek, D.C. (1977). Early acquisition of cytomegalovirus and Epstein-Barr virus antibody in several isolated Me- lanesian populations. Am. J. Epidemiol. 105:480.PubMedGoogle Scholar
  71. Lemon, S.M., Hütt, L.M., Shaw, J.E., et al. (1977). Replication of EBV in epithelial cells during infectious mononucleosis. Nature 268:268.PubMedGoogle Scholar
  72. Levy, J.A., and Henle, G. (1966). Indirect immuno- fluorescent tests with sera from African children and cultured Burkitt lymphoma cells. J. Bacteriol 92:275.PubMedGoogle Scholar
  73. McKendrick, M.W., Gesses, A.M., and Edwards J. (1979). Atypical infectious mononucleosis in the elderly. For. Med. J. 2:970.Google Scholar
  74. Mangi, G., Niederman, J.C., Kelleher, J.E., et al. (1974). Depression of cell mediated immunity during acute infectious mononucleosis. N. Engl. J. Med. 291:1149.PubMedGoogle Scholar
  75. Martin, P.J., Shulman, H.M., Schubach, W.H., et al. (1984). Fatal Epstein-Barr-virus-associated proliferation of donor B cells after treatment of acute graft- versus-host disease with a murine anti-T-cell antibody. Ann. Intern. Med. 101:310.PubMedGoogle Scholar
  76. Miller, G., Niederman, J.C., and Andrews, L. (1973). Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis. N. Engl. J. Med 288:299.Google Scholar
  77. Newell, K.W. (1957). The reported incidence of glandular fever, and analysis of a report of the Public Health Laboratory Service. J. Clin. Path. 10:20.PubMedGoogle Scholar
  78. Niederman, J.C., Evans, A.S., Subrahmanyan, L., et al. (1970). Prevalence, incidence, and persistence of EB virus antibody in young aduhs. N. Engl. J. Med. 282:361.PubMedGoogle Scholar
  79. Nolan, R.A., (1935). Report of so-called epidemic of glandular fever (infectious mononucleosis).U.S. Nav. Med Bull. 33:479.Google Scholar
  80. Nye, F.S., and Lambert, H.D. (1973). Epstein-Barr virus antibody in cases and contacts of infectious mononucleosis: A family study. J. Hyg. (Camb.) 71:151.Google Scholar
  81. Nyfelt, A. (1932). Klinische und experimentelle Untersuchungen über die mononucleosis infectiosa. Folia Haemat. 47:1.Google Scholar
  82. Paloheima, J. A., and Halonen, P. L. (1965). A case of mononucleosis-like syndrome after blood transfusion from a donor with asymptomatic mononucleosis. J. Cardiovasc. Surg. 6:558.Google Scholar
  83. Pass, R.F., Hutto, S.C., Reynolds, D.W., et al. (1984). Increased frequency of cytomegalovirus infection in children in group day care. Pediatrics 74:121.PubMedGoogle Scholar
  84. Paul, J.R., and Bunnell, W. (1932). The presence of heterophil antibodies in infectious mononucleosis. Am. J. Med Sei. 183:90.Google Scholar
  85. Paul, O. (1945). Mononucleosis on board a destroyer. U.S. Nav. Med Bull. 44:614.Google Scholar
  86. Penman, H.G. (1966). The incidence of glandular fever. J. Hyg. (Camb.) 64:457.Google Scholar
  87. Pereira, M.S., Blake, J.M., and Macrae, A.D. (1969). EB vims antibody at different ages. Br. Med. J. 4:526.PubMedGoogle Scholar
  88. Pereira, M.S., Field, A.M., Blake, J.M., et al. (1972). Evidence for oral excretion of EB virus in infectious mononucleosis. Lancet 1:710.PubMedGoogle Scholar
  89. Pfeiffer, E. (1889). Drüsenfieber. Jahrb. F. Kinder 29:257.Google Scholar
  90. Phillips, K.D., and Stone, D.G.H. (1956). Glandular fever at the age of 6 weeks. Br. Med. J. 2:1222.PubMedGoogle Scholar
  91. Pickens, S. and McMurdoch, C.J. (1979). Infectious mononucleosis in the elderly.Age Aging 8:93.Google Scholar
  92. Porter, D.D., Wimberly, I., and Benyish-Melnick, M. (1969). Prevalence of anti-bodies to EB virus and other herpesviruses. JAMA 208:1675.PubMedGoogle Scholar
  93. Price, J.P. (1930). Infectious mononucleosis. Am. J. Dis. CA/W 40:581.Google Scholar
  94. Purtilo, D.T. (1981). Malignant lymphoproliferative diseases induced by Epstein-Barr virus in immuno- deficient patients, including X-linked, cytogenetic, and familial syndromes. Cancer Gen. Cytogen. 4:251.Google Scholar
  95. Purtilo, D.T., DeFlorio, Jr., D., Hütt, L.M., et al. (1977). Variable phenotypic expression of an X- linked recessive lymphoproliferative syndrome. N. Engl. J. Med. 297:1077.PubMedGoogle Scholar
  96. Purtilo, D.T., Paquin, L.A., Sakamoto, K., et al. (1980). Persistent transfusion-associated infectious mononucleosis with transient acquired immunodeficiency. Am. J. Med. 68:437.PubMedGoogle Scholar
  97. Quinnan, G.V., Masur, H., Rook, A.H., et al. (1984). Prevalence and possible relationship of herpesvirus infections to the etiology of the acquired immunodeficiency syndrome. JAMA 252:72.PubMedGoogle Scholar
  98. Rocchi, F., DeFelici, A., Ragona, G., et al. (1977). Quantitative evaluation of Epstein-Barr virus-in- fected mononuclear peripheral blood leukocytes in infectious mononucleosis. N. Engl. J. Med. 296: 132.PubMedGoogle Scholar
  99. Royston, I., Sullivan, J. L., Perlman, P. O., et al. (1975). Cell-mediated immunity to Epstein-Barr virus-transformed lymphoblastoid cells in acute infectious mononucleosis.N. Engl. J. Med. 293:1159.PubMedGoogle Scholar
  100. Sawyer, R.N., Evans, A.S., Niederman, J.C., et al. (1971). Prospective studies of a group of Yale University freshmen. I. Occurrence of infectious mononucleosis. J. Infect. Dis. 123:263.PubMedGoogle Scholar
  101. Schmitz, H., Volz, D., Kraineck-Riechbert, C.M., et al. (1972). Acute Epstein-Barr virus infections in children. Med. Microbiol. Immunol. 158:58.PubMedGoogle Scholar
  102. Schultz, A. L., and Hall, W. H. (1952). Clinical observation in 100 cases of infectious mononucleosis and the results of treatment with penicillin and aureomycin.Ann. Intern. Med. 36:1498.PubMedGoogle Scholar
  103. Shadduck, R.K., Winkelstein, A., Zeigler, Z., et al. (1979). Aplastic anemia following infectious mononucleosis: Possible immune etiology. Exp. Hemat. 7:264.PubMedGoogle Scholar
  104. Shearer, W.J., Ritz, J., Finegold, M.J., et al. (1985). Epstein-Barr virus-associated B-cell proliferations of diverse clonal origins after bone marrow transplantation in a 12-year-old patient with severe combined immunodeficiency. N. Engl. J. Med. 312:1151.PubMedGoogle Scholar
  105. Sheldon, P.J., Papamichael, M., Hemsted, E.H., et al. (1973) Thymic origin of atypical lymphoid cells in infectious mononucleosis. Lancet 1:1153.PubMedGoogle Scholar
  106. Sohier, R., Lepine, P., and Sautter, V. (1940). Recherches sur la transmission experimentale de la mononucleose infectieuse au singe et ä I’homme. Ann. Inst. Pasteur 65:50–62.Google Scholar
  107. Sixbey, J.W., Vesterinen, E.H., Nedrud, J.G., et al. (1983). Replication of Epstein-Barr virus in human epithelial cells infected in vitro. Nature 306:480.PubMedGoogle Scholar
  108. Sixbey, J.W., Lemon, S.M., and Pagano, J.S. (1986). A second site for Epstein-Barr virus shedding: The uterine cervix. Lancet, 11:1122.Google Scholar
  109. Smith, D.R. (1964). A syndrome resembling infectious mononucleosis after heart surgery.Brit. Med. J. 1:945.PubMedGoogle Scholar
  110. Solem, J.H., and Jorgensen, W. (1969). Accidentally transmitted infectious mononucleosis. Acta Med. Scand 186:433.PubMedGoogle Scholar
  111. Starling, K.A., and Fembach, D.J. (1968). Infectious mononucleosis in the preschool child. JAMA 203:294.Google Scholar
  112. Storrie, M.C., Sphar, R., Sawyer, R.N., et al. (1976). Seroepidemiological studies of polaris submarine crews. II. Infectious mononucleosis. Milit. Med. 141:30.Google Scholar
  113. Strauch, B., Siegel, N., Andrews, L., et al. (1974). Oropharyngeal excretion of Epstein-Barr virus by renal transplant recipients and other patients treated with immunosuppresive drugs. Lancet 1:234.PubMedGoogle Scholar
  114. Strom, J. (1960). Infectious mononucleosis—is the incidence increasing? Acta Med. Scand. 168:35.Google Scholar
  115. Sumaya, C.V., Boswell, R.N., Ench, Y., et al. (1986). Enhanced serological and virological findings of Epstein-Barr virus in patients with AIDS and AIDS-related complex. J. Infect. Dis. 154:864.PubMedGoogle Scholar
  116. Sumaya, C.V., Downey, J., and Ullis, K.C. (1978). Tonsillectomy and infectious mononucleosis. Am. J. Epidemiol. 107:65.PubMedGoogle Scholar
  117. Sumaya, C.V., and Ench, Y., (1981). Epstein-Barr virus infections: Transmission and host response. In The Human Herpesviruses, A. J. Nahmias, et al. (eds.). Elsevier, New York, p. 613.Google Scholar
  118. Sumaya, C.F., and Ench, Y. (1985a). Epstein-Barr virus infectious mononucleosis in children. I. Clinical and general laboratory findings. Pediatrics 75:1003, attached.PubMedGoogle Scholar
  119. Sumaya, C.V., and Ench, Y. (1985b). Epstein-Barr virus infectious mononucleosis in children. II. Heterophil antibody and viral-specific responses. Pediatrics 75:1011.PubMedGoogle Scholar
  120. Sumaya, C.V., and Ench, Y. (1986). Epstein-Barr virus infections in families: The role of children with infectious mononucleosis. J. Infec. Dis. 154:842.Google Scholar
  121. Svedmyr, E., Emberg, I., Seeley, J., et al. (1984). Virologie, immunologic and clinical observations on a patient during the incubation, acute, and convalescent phases of infectious mononucleosis. Clin. Immunol. Immunopath. 30:437.Google Scholar
  122. Svedmyr, E., and Jondal, M. (1975). Cytotoxic effector cells specific for B cell lines transformed by Epstein-Barr virus are present within patients in infectious mononucleosis. Proc. Nat. Acad. Sei. (USA) 72:1622.Google Scholar
  123. Tallqvist, H., Henle, W., Klemola, E., et al. (1973). Antibodies to Epstein-Barr virus at the ages of 6 to 23 months in children with congenital heart disease. Scand. J. Infec. Dis. 5:159.Google Scholar
  124. Taylor, A.W. (1953). Effects of glandular fever infection in acute leukemia. Lancet 1:589.Google Scholar
  125. Tidy, H. L., and Daniel, E. G. (1923). Glandular fever and infective mononucleosis with an account of an epidemic. Lancet 2:9.Google Scholar
  126. Tischendorf, P., Shramek, G.J., Balagtas, R.C., et al. (1970). Development and persistence of immunity to Epstein-Barr virus in man. J. Infect. Dis. 122:401.PubMedGoogle Scholar
  127. Turner, R.A., MacDonald, R.N., and Cooper, B.S. (1972). Transmission of infectious mononucleosis by transmission of pre-illness plasma. Ann. Intern. Med. 77:751.PubMedGoogle Scholar
  128. University Health Physicians and P.H.L.S. Laboratories (1971). Infectious mononucleosis and its relationship to EB virus antibody. Br. Med. J. 4:643.Google Scholar
  129. Virtanen, S. (1962). Incidence of infectious mononucleosis antibodies in blood donors. Acta Pathol. Microbiol. Scand. 56:530.Google Scholar
  130. Wahren, B., Lantorp, K., Sterner, G., et al. (1970). EBV antibodies in family contacts of patients with infectious mononucleosis. Proc. Soc, Exp. Biol. Med. 133:934.Google Scholar
  131. Walker, S.H. (1951). Infectious mononucleosis manifested by diarrhea. U.S. Armed Forces Med. J. 2:1875.PubMedGoogle Scholar
  132. Wechsler, H.F., Rosenblum, A.H., and Sills, C.T. (1946). Infectious mononucleosis: Report of an epidemic in an army post. Ann. Intern. Med. 25:113.PubMedGoogle Scholar
  133. West, J.P. (1896). An epidemic of glandular fever. Arch. Ped 13:889.Google Scholar
  134. Wising, P.J. (1939). Some experiments with lymph gland material from cases of infectious mononucleosis. Acta Med Scand 98:328.Google Scholar
  135. Wising, P. J. (1942). Successful transmission of infectious mononucleosis to man by transfusion of hep- arinized blood. Acta Med. Scand. 109:507.Google Scholar
  136. Woodward, W. K., Thiele, R. L., and Fuller, R. (1954). Marked lymphocytic reaction in a one-month-old infant with problem infectious mononucleosis. J. Ped 45:717.Google Scholar
  137. Yadav, M.S., Malliga, N., and Ablashi, D.V. (1987). Development of immunity to Epstein-Barr virus in Malaysian children. Microbiologica 10:29.PubMedGoogle Scholar
  138. Yao, Q.Y., Rickinson, A.B., and Epstein, M.A. (1985). A re-examination of the Epstein-Barr virus carrier state in healthy seropositive individuals. Int. J. Cancer 35:35.PubMedGoogle Scholar

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  • Stephen E. Straus
  • Gary R. Fleisher

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