Pathology of Infectious Mononucleosis

  • Barbara H. Tindle
Part of the Clinical Topics in Infectious Disease book series (CLIN.TOP.INFECT)


The histopathology of infectious mononucleosis was described in 1920 by Sprunt and Evans, whose findings were based on lymph node biopsy sections from three of six individuals who were afflicted with this malady. Several reports subsequently stressed the lymphoid hyperplasia in various tissues and suggested similarities between this reactive lesion and lymphoproliferative neoplasms (Longcope 1922; Baldridge, Rohner, and Hansmann 1926; Downey and Stasney 1936; Gall and Stout 1940; Custer and Smith 1948). In more recent publications, while the problem of distinguishing between reactive and neoplastic processes is cited, specific histopathologic differences between infectious mononucleosis and malignant lymphoma are also discussed and emphasized (Lukes, Tindle, and Parker 1969; McMahon, Gordon, and Rosen 1970; Agliozzzo and Reingold 1971; Salvador, Harrison, and Kyle 1972; Tindle, Parker, and Lukes 1972; Gowing 1975). The identification of the cellular proliferation in infectious mononucleosis as predominantly that of immunoblasts, as cells resulting from antigenic stimulation (Dameshek 1963), has contributed greatly to our interpretation and understanding of this and other immunoblastic processes.


Infectious Mononucleosis Atypical Lymphocyte Lymphogranuloma Venereum Sternberg Cell Epithelioid Histiocyte 
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