Diagnostic Criteria and Differential Diagnosis

  • Tom D. Y. Chin
Part of the Clinical Topics in Infectious Disease book series (CLIN.TOP.INFECT)


Infectious mononucleosis is usually a benign, self-limited disease occurring most commonly in adolescents and young adults. It is an acute illness characterized by fever, sore throat, generalized lymphadenopathy, lymphocytosis with atypical lymphocytes, and development of heterophile agglutinins, ox cell hemolysin, and antibodies to Epstein-Barr virus (EBV).


Sore Throat Lyme Disease Infectious Mononucleosis Streptococcal Pharyngitis Atypical Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anderson, S.E., and Remington, J.S. (1975). The diagnosis of toxoplasmosis. South. Med. J. 68:1433.PubMedCrossRefGoogle Scholar
  2. Balakrishnan, S.L., Armstrong, D., Rubin, A.L., and Stenzel, K.H. (1969). Cytomegalovirus infection after renal transplantation. JAMA 207:1712.PubMedCrossRefGoogle Scholar
  3. Bradley, D.W. (1980). Hepatitis A virus infection: Pathogenesis and serodiagnosis of acute disease. J. Virol. Methods 2:31.PubMedCrossRefGoogle Scholar
  4. Davidsohn, I., and Henry, J.B. (1969). Todd-Sanford Clinical Diagnosis by Laboratory Methods, 15th ed. Philadelphia, W.B. Saunders Company.Google Scholar
  5. Evans, A.S. (1969). Infectious mononucleosis: Recent developments. GP 40:127.PubMedGoogle Scholar
  6. Evans, A.S., Niederman, J.C., Cenabre, L.C., et al. (1975). A prospective evaluation of heterophile and Epstein-Barr virus-specific IgM antibody tests in clinical and subclinical infectious mononucleosis: Specificity and sensitivity of the tests and persistence of antibody. J. Infect. Dis. 132:546.PubMedCrossRefGoogle Scholar
  7. Finch, S.C. (1969). Clinical symptoms and signs of infectious mononucleosis. In Infectious Mononucleosis. R.L. Carter and H.G. Penman (eds.). Oxford, Blackwell Scientific Publications, pp. 19–46.Google Scholar
  8. Foster, K.M., and Jack, I. (1969). A prospective study of the role of cytomegalovirus in post-transfusion mononucleosis.N. Engl. J. Med. 280:1311.PubMedCrossRefGoogle Scholar
  9. Fox, M.D., and Kaufmann, A.F. (1977). Brucellosis in the United States. J. Infect. Dis. 136:312.CrossRefGoogle Scholar
  10. Heath, C.W., Jr., Alexander, A.D., and Galton, M.M. (1965). Leptospirosis in the United States: Analysis of 483 cases in man, 1949–1961. IV. Engl. J. Med 273:857.CrossRefGoogle Scholar
  11. Henle, W., Henle, G.E., and Horwitz, C.A. (1974). Epstein-Barr virus specific diagnostic tests in infectious mononucleosis. Human Pathol. 5:551.CrossRefGoogle Scholar
  12. Ho, D.D., Samgadharan, M.G., Resnick, L., et al. (1985). Primary human T-lymphotropic virus type III infection. Ann. Intern. Med. 103:880.PubMedGoogle Scholar
  13. Hoagland, R.J. (1967). Infectious Mononucleosis. New York, Grune & Stratton.Google Scholar
  14. Horwitz, M.S., and Moore, G.T. (1968). Acute infectious lymphocytosis: An etiologic and epidemiologic study of an outbreak. N. Engl. J. Med. 279:399.PubMedCrossRefGoogle Scholar
  15. Horwitz, C.A., Henle, W., Henle, G., et al. (1979). Persistent falsely positive rapid tests for infectious mononucleosis. Report of five cases with four-six- year follow-up data. Am. J. Clin. Pathol. 72:807.PubMedGoogle Scholar
  16. Jordan, M.C., Rousseau, W.E., Stewart, J.A., et al. (1973). Spontaneous cytomegalovirus mononucleosis: clinical and laboratory observations in nine cases. Ann. Intern. Med. 79:153.PubMedGoogle Scholar
  17. Klemola, E., von Essen, R., Henle, G., et al. (1970). Infectious mononucleosis-like disease with negative heterophile agglutination test: clinical features in relation to Epstein-Barr virus and cytomegalovirus antibodies.J. Infect. Dis. 121:608.PubMedCrossRefGoogle Scholar
  18. Lang, D.J., and Hanshaw, J.B. (1969). Cytomegalovirus infection and the postperfusion syndrome: recognition of primary infections in four patients.N. Engl.J. Med 280:1145PubMedCrossRefGoogle Scholar
  19. Lemon, S.M., Gates, N.L., Simms, T.E., and Bancroft, W.H. (1981). IgM antibody to hepatitis B core antigen as a diagnostic parameter of acute infection with hepatitis B virus. J. Infect. Dis. 143:803.PubMedCrossRefGoogle Scholar
  20. Maynard, J.E. (1986). Hepatitis. In Maxcey-Rosenau Public Health and Preventive Medicine, 12th ed., John M. Last (ed.). New York, Appleton-Century- Crofts, pp. 176–187.Google Scholar
  21. Niederman, J.C. (1956). Infectious mononucleosis at the Yale-New Haven Medical Center 1946–1955. Yale J. Biol Med 28:629.PubMedGoogle Scholar
  22. Niederman, J.C., McCollum, R.W., Henle, G., et al. (1968). Infectious mononucleosis: Clinical manifestations in relation to EB virus antibodies. JAMA 203:205.PubMedCrossRefGoogle Scholar
  23. Rousseau, W.E., Noble, G.R., Chin, T.D.Y., et al. Unpublished data.Google Scholar
  24. Spink, W.W. (1956). The Nature of Brucellosis. Minneapolis, University of Minnesota Press.Google Scholar
  25. Steere, A.C., Bartenhagen, N.H., Craft, J.E., et al. (1983). The early clinical manifestations of Lyme disease. Ann. Intern. Med. 99:76.PubMedGoogle Scholar
  26. Wiesner, P.J., Tronca, E., Bonin, P., et al. (1972). Clinical spectrum of pharyngeal gonococcal infection. N. Engl J Med 228:181.Google Scholar
  27. Wood, T.A., and Frenkel, E.P. (1967). The atypical lymphocyte. Am J. Med. 43:923.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Tom D. Y. Chin

There are no affiliations available

Personalised recommendations