Artificial Insemination by Donor: Discrete time survival data with crossed and nested random effects
A discrete time survival problem arising in studies of artificial insemination by donor is described. This problem involves two levels of “ frailty” effect to model heterogeneity of female fecundability, together with a further two nested sets of random effects for sperm donor and donation. Parametric and non-parametric approaches to modelling such data are discussed, and computational difficulties highlighted. Attention is also drawn to the relationship of such problems to the extensive literature on generalised linear mixed models.
KeywordsCovariance Infertility Rene Clomiphene Azoospermia
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