Angiography in Experimental Atherosclerosis

Advantages and Limitations
  • Ralph G. DePalma
  • Errol M. Bellon


The ability to detect atherosclerotic plaques and to document changes in their luminal intrusion in seriatim are important operational goals of experimental design. During the past 12 years we have evolved methods for serial arteriography in monkeys and dogs (1–3) and have performed more than 100 of these procedures. Initially, arteriography was used as a tool in experimental atherosclerosis much as it is used clinically: to detect the presence of gross atherosclerotic disease. Serial interventions in animal models, which could not be performed in humans, made it possible to monitor radiographically atherosclerotic plaque dynamics at known and characteristic sites (4,5). Angiography in combination with serial morphologic observations was found to be useful in detecting regressive lesion change in individual animals (6,7). This report presents data on sensitivity and specificity of angiography for detection of atherosclerosis. These data also provide an estimate of the degree of discrepancy between angiographic and conventional pathologic grading. Advantages of angiography, as well as its assumptions and limits, will be considered in relationship to experimental design.


Internal Carotid Artery Cynomolgus Monkey Inferior Mesenteric Artery Lumbar Artery Atherogenic Diet 
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Copyright information

© Springer-Verlag New York Inc. 1983

Authors and Affiliations

  • Ralph G. DePalma
  • Errol M. Bellon

There are no affiliations available

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