Angiography in Experimental Atherosclerosis
The ability to detect atherosclerotic plaques and to document changes in their luminal intrusion in seriatim are important operational goals of experimental design. During the past 12 years we have evolved methods for serial arteriography in monkeys and dogs (1–3) and have performed more than 100 of these procedures. Initially, arteriography was used as a tool in experimental atherosclerosis much as it is used clinically: to detect the presence of gross atherosclerotic disease. Serial interventions in animal models, which could not be performed in humans, made it possible to monitor radiographically atherosclerotic plaque dynamics at known and characteristic sites (4,5). Angiography in combination with serial morphologic observations was found to be useful in detecting regressive lesion change in individual animals (6,7). This report presents data on sensitivity and specificity of angiography for detection of atherosclerosis. These data also provide an estimate of the degree of discrepancy between angiographic and conventional pathologic grading. Advantages of angiography, as well as its assumptions and limits, will be considered in relationship to experimental design.
KeywordsInternal Carotid Artery Cynomolgus Monkey Inferior Mesenteric Artery Lumbar Artery Atherogenic Diet
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- 2.DePalma RG, Bellon EM, Insull W, Roth WT, Robinson AV (1972) Studies on progression and regression of experimental atherosclerosis. Techniques and application to the rhesus monkey. In: Goldsmith EI, Moor-Jankowski J (eds) Medical Primatology. Karger, Basel III, pp 313–323Google Scholar
- 4.Bellon EM, DePalma RG, Klein L, Koletsky S, Robinson AV (1979) The utility of arteriography in the evaluation of experimental atherosclerosis: a ten-year experience with rhesus and fascicularis monkeys. Abstracts of Fifth International Symposium on Atherosclerosis, Houston, TXGoogle Scholar
- 8.DePalma RG, Bellon EM, Manalo PM (1981) Failure of anti-platelet agents to control dietary atherosclerosis. J Cardiovasc Surg 22: 445Google Scholar
- 9.Klein L, DePalma RG, Insull W Jr, Koletsky S, Bellon EM (1976) Stability of original collagen and elastin and gain of new collagen in atherosclerotic plaques. Abstracts of 30th Annual Meeting Council on Atherosclerosis, p 3Google Scholar
- 10.Wissler RW (1968) Recent progress in studies of experimental primate atherosclerosis. Prog Biochem Pharmacol 4: 378–392Google Scholar
- 13.DePalma RG (1981) Regression or arrest of atherosclerosis-Does it happen? In: Greenhalgh RM (ed) Proceedings of International Symposium: Hormones and vascular disease. Pitman Publishers, Ltd, London, pp 71–92Google Scholar
- 14.Blankenhorn DH, Brooks SH, Selzer RH, Barndt R (1978) The rate of atherosclerosis change during treatment of hyperlipoproteinemia. Circulation 57: 335–361Google Scholar
- 15.Bond MG, Bullock BC, Lehner NDM, Clarkson TB (1978) Regression of primate carotid artery atherosclerosis at 200 vs 300 mg/di plasma cholesterol concentration. Stroke 9: 97–98Google Scholar
- 16.Bond MG, Adams MR, Kaduck JM, Bullock BC (1981) The effects of coronary artery size: Implications for myocardial infarction. Fed Proc 40: 773Google Scholar
- 18.DePalma RG (1981) Biochemical abnormalities and atherosclerotic aneurysm. In: Bergan JJ, Yao JST (eds) Aneurysms: Diagnosis and treatment. Grune and Stratton, New York, pp 45–59Google Scholar