Quantitative evaluation of lesions has an established and important role in atherosclerosis research. Atheroma measurement procedures were first used by European pathologists to study the relative distribution of lesions in various parts of the vascular system. These efforts led eventually to the extensive geographic surveys of atherosclerosis with standardized autopsy measurements, which have contributed much to the knowledge of atherogenesis. Quantitation of experimental atherosclerosis began shortly after it was shown that atherosclerosis could be induced in animal models, and has been extensively used to compare the potency of various atherogenic stimuli. Quantitation of lesions now plays a central role in studies of atheroma regression in experimental animals.
KeywordsLiving Subject Coronary Drug Project Coronary Artery Surgery Study Imaging Vessel Wall Human Lesion
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