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Isolated Preparations: Dose—Response Data

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Book cover The Dose—Response Relation in Pharmacology

Abstract

Much of our practical knowledge of pharmacology and many of the theories of drug action have been attained from experiments conducted on isolated preparations. When we work with isolated preparations we can observe the direct actions of drugs on the organ of interest. These observations are reasonably unencumbered by the many compensatory mechanisms of the organism that often mask the drugs’ direct actions. Yet, working at this level, we remain within the realm of investigation that permits us to connect observations on the whole animal with the more intimate action of drugs on individual molecules. In this chapter we discuss several of these isolated preparations and present dose-response data for selected agents which act on them.

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Author information

Authors and Affiliations

  1. Temple University School of Medicine, 19140, Philadelphia, Pennsylvania, USA

    Ronald J. Tallarida Ph.D. (Professor of Pharmacology)

  2. Department of Anesthesiology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania, USA

    Leonard S. Jacob M.D., Ph.D. (Faculty, Visiting Assistant Professor of Pharmacology)

  3. Department of Pharmacology, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania, USA

    Leonard S. Jacob M.D., Ph.D. (Faculty, Visiting Assistant Professor of Pharmacology)

  4. Medical College of Pennsylvania, 19129, Philadelphia, Pennsylvania, USA

    Leonard S. Jacob M.D., Ph.D. (Faculty, Visiting Assistant Professor of Pharmacology)

Authors
  1. Ronald J. Tallarida Ph.D.
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  2. Leonard S. Jacob M.D., Ph.D.
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© 1979 Springer-Verlag New York Inc.

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Tallarida, R.J., Jacob, L.S. (1979). Isolated Preparations: Dose—Response Data. In: The Dose—Response Relation in Pharmacology. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-6265-4_6

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  • DOI: https://doi.org/10.1007/978-1-4684-6265-4_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-6267-8

  • Online ISBN: 978-1-4684-6265-4

  • eBook Packages: Springer Book Archive

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