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Isolated Preparations: Dose—Response Data

  • Ronald J. Tallarida
  • Leonard S. Jacob

Abstract

Much of our practical knowledge of pharmacology and many of the theories of drug action have been attained from experiments conducted on isolated preparations. When we work with isolated preparations we can observe the direct actions of drugs on the organ of interest. These observations are reasonably unencumbered by the many compensatory mechanisms of the organism that often mask the drugs’ direct actions. Yet, working at this level, we remain within the realm of investigation that permits us to connect observations on the whole animal with the more intimate action of drugs on individual molecules. In this chapter we discuss several of these isolated preparations and present dose-response data for selected agents which act on them.

Keywords

Phrenic Nerve Hypogastric Nerve Isolate Rabbit Heart Rabbit Thoracic Aorta Rabbit Aortic Strip 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1979

Authors and Affiliations

  • Ronald J. Tallarida
    • 1
  • Leonard S. Jacob
    • 2
    • 3
    • 4
  1. 1.Temple University School of MedicinePhiladelphiaUSA
  2. 2.Department of AnesthesiologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  3. 3.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  4. 4.Medical College of PennsylvaniaPhiladelphiaUSA

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