Construction of Dose—Response Curves: Statistical Considerations

  • Ronald J. Tallarida
  • Leonard S. Jacob


Biological systems demonstrate variability in their responses to drugs. Thus, the same muscle taken from two different animals (of the same species) and studied in vitro under controlled conditions will often give quantitatively different responses to identical doses of the same drug. Such variability is not unexpected since each muscle contains a large number of muscle fibers, and even the most careful surgical preparation of each is not likely to yield identical specimens. In addition to the variability in drug response that is due to slight differences in muscle composition or muscle orientation, there are other (unknown) factors that contribute to the variability. Indeed, there is generally even greater variability in drug responses in the whole animal, regardless of what response is measured. For these reasons we must use mean responses or average responses.


Drug Response Normal Curve Statistical Consideration Sample Standard Deviation Morphine Sulfate 
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Copyright information

© Springer-Verlag New York Inc. 1979

Authors and Affiliations

  • Ronald J. Tallarida
    • 1
  • Leonard S. Jacob
    • 2
    • 3
    • 4
  1. 1.Temple University School of MedicinePhiladelphiaUSA
  2. 2.Department of AnesthesiologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  3. 3.Department of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  4. 4.Medical College of PennsylvaniaPhiladelphiaUSA

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