The Action of Radiation on Viruses

  • Hermann Dertinger
  • Horst Jung
Part of the Heidelberg Science Library book series (HSL)


Viruses are biological objects which have no metabolism of their own and can replicate only with the aid of the genetic and metabolic systems of a host cell, i. e. they are “parasites at the molecular level”. If the host cell is a bacterium they are referred to as bacteriophages, or phages. Since the effects of radiation have been investigated more thoroughly in bacterial viruses than in other systems, a large proportion of the experimental material discussed in this chapter is derived from investigations on bacteriophages.


Strand Break Double Strand Break Single Strand Break Radiation Sensitivity Inactivation Curve 
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  1. Adams, M. H.: Bacteriophages. New York: Interscience Publ. 1959.Google Scholar
  2. Aurisicchio, S., Coppo, A., Frontali, C., Graziosi, F., Toschi, G.: Nuovo Cimento 25, 35 (1962).CrossRefGoogle Scholar
  3. Becarevic, A., Djordjevic, B., Sutic, D.: Nature 198, 612 (1963).PubMedCrossRefGoogle Scholar
  4. Bohne, L., Coquerelle, Th., Hagen, U.: Int. J. Radiat. Biol., in press (1970)Google Scholar
  5. Boyce, R. P., Tepper, M.: Virology 34, 344 (1968).PubMedCrossRefGoogle Scholar
  6. Celano, A., Aurisicchio, S., Coppo, A., Domini, P., Graziosi, F.: Nuovo Cimento 18, 190 (1960).CrossRefGoogle Scholar
  7. Denhardt, D. T., Sinsheimer, R. L.: J. molec. Biol. 12, 663 (1965).CrossRefGoogle Scholar
  8. Dewey, D. L., Stein, G.: Nature 217, 351 (1968).PubMedCrossRefGoogle Scholar
  9. Freifelder, D.: Proc. nat. Acad. Sci. (Wash.) 54, 128 (1965).CrossRefGoogle Scholar
  10. Freifelder, D.: Proc. nat. Acad. Sci. Virology 30, 328 (1966).CrossRefGoogle Scholar
  11. Freifelder, D.: Proc. nat. Acad. Sci. Freifelder, D. R.: Mutation Res. 3, 177 (1966).CrossRefGoogle Scholar
  12. Ginoza, W.: Ann. Rev. Microbiol. 21, 325 (1967).CrossRefGoogle Scholar
  13. Freifelder, D.: Proc. nat. Acad. Sci. Miller, R. C.: Proc. nat. Acad. Sci. (Wash.) 54, 551 (1965).CrossRefGoogle Scholar
  14. Harm, W.: In: Repair from genetic radiation damage. Ed.: F. H. Sobels. New York: Pergamon Press 1963, p. 107.Google Scholar
  15. Harm, W.: Z. Vererbungsl. 94, 67 (1963b).CrossRefGoogle Scholar
  16. Harm, W.: Mutation Res. 1, 344 (1964).CrossRefGoogle Scholar
  17. Haynes, R. H., Baker, R. M., Jones, G. E.: In: Energetics and mechanisms in radiation biology. Ed.: G. O. Phillips. London, New York: Academic Press 1968, p. 425.Google Scholar
  18. Herak, J. N., Gordy, W.: Proc. nat. Acad. Sci. (Wash.) 56, 1354 (1966).CrossRefGoogle Scholar
  19. Hotz, G.: Biochem. biophys. Res. Commun. 11, 393 (1963).Google Scholar
  20. Hotz, G.: Z. Vererbungsl. 95, 211 (1964).PubMedCrossRefGoogle Scholar
  21. Hotz, G.: Photochem. Photobiol., in press (1970).Google Scholar
  22. Hotz, G.: Reuschl, H.: Molec. Gen. Genetics 99, 5 (1967).CrossRefGoogle Scholar
  23. Hotz, G.: Zimmer, K. G.: Int. J. Radiat. Biol. 7, 75 (1963).CrossRefGoogle Scholar
  24. Howard-Flanders, P.: Ann. Rev. Biochem. 37, 175 (1968).PubMedCrossRefGoogle Scholar
  25. Howard-Flanders, P.: Boyce, R. P., Theriot, L.: Nature 195, 51 (1962).CrossRefGoogle Scholar
  26. Hüttermann, J., Müller, A.: Int. J. Radiat. Biol. 15, 297 (1969).CrossRefGoogle Scholar
  27. Ikenaga, M.: Radiat. Res. 34, 421 (1968).PubMedCrossRefGoogle Scholar
  28. Jung, H., Kürzinger, K.: Radiat. Res. 36, 369 (1968).PubMedCrossRefGoogle Scholar
  29. Kaplan, H. S.: In: Actions chimiques et biologiques des radiations, Tome 12. Ed.: M. Haissinsky. Paris: Masson et Cie 1968, p. 69.Google Scholar
  30. Lytle, C. D., Ginoza, W.: Virology 38, 152 (1969a).PubMedCrossRefGoogle Scholar
  31. Lytle, C. D., Int. J. Radiat. Biol. 14, 553 (1969b).CrossRefGoogle Scholar
  32. Müller, A., Köhnlein, W., Zimmer, K. G.: J. Mol. Biol. 7, 92 (1963).CrossRefGoogle Scholar
  33. Réslovâ, S., Drobnik, J.: Biochem. biophys. Res. Commun. 31, 119 (1968).Google Scholar
  34. Rörsch, A., van de Camp, C., Adema, J.: Biochim biophys. Acta (Amst.) 80, 246 (1964).Google Scholar
  35. Rupert, C. S., Harm, W.: In: Advances in radiation biology, Vol. 2. Eds.: L. G. Augenstein, R. Mason, and M. Zelle. New York: Academic Press 1966, p. 1. Sauerbier, W.: Virology 17, 164 (1962).Google Scholar
  36. Rupert, C. S., Harm, W.: Z. Vererbungsl. 95, 145 (1964).CrossRefGoogle Scholar
  37. Rupert, C. S., Harm, W.: Biochem. biophys. Res. Commun. 17, 46 (1964).Google Scholar
  38. Setlow, R., Boyce, R. P.: Biochim. biophys. Acta (Amst.) 68, 455 (1963).CrossRefGoogle Scholar
  39. Sinsheimer, R. L.: Progr. Nucleic Acid Res. 8, 115 (1968).CrossRefGoogle Scholar
  40. Stahl, F. W., Crasemann, J. M., Okun, L., Fox, E., Laird, C.: Virology 13, 98 (1961).CrossRefGoogle Scholar
  41. Stent, G. S.: Molecular biology of bacterial viruses. San Francisco: W. H. Freeman & Co 1963.Google Scholar
  42. Stent, G. S.: Fuerst, C. R.: In: Advances in biological and medical physics, Vol. VII. Eds.: C. A. Tobias and J. H. Lawrence. New York: Academic Press 1960, p. 1. Symonds, N.: J. molec. Biol. 4, 319 (1962).Google Scholar
  43. Tanooka, H.: Radiat. Res. 21, 26 (1964).PubMedCrossRefGoogle Scholar
  44. Taylor, W. D., Ginoza, W.: Proc. nat. Acad. Sci. (Wash.) 58, 1753 (1967).CrossRefGoogle Scholar
  45. Tocchini-Valentini, G. P., Stodolsky, M., Aurisicchio, A., Sarnat, M., Graziosi, F.,Weiss, S. B., Geiduschek, E. P.: Proc. nat. Acad. Sci. (Wash.) 50, 935 (1963).CrossRefGoogle Scholar
  46. Watson, J. D.: J. Bact. 60, 697 (1950).PubMedGoogle Scholar
  47. Watson, J. D.: J. Bacteriol. 63, 473 (1952).PubMedGoogle Scholar
  48. Weil, R.: Proc. nat. Acad. Sci. (Wash.) 49, 480 (1963).CrossRefGoogle Scholar
  49. Weiss, W., Richardson, C.: Proc. nat. Acad. Sci. (Wash.) 57, 1021 (1967).CrossRefGoogle Scholar
  50. Winkler, U.: Photochem. Photobiol. 3, 37 (1964a).CrossRefGoogle Scholar
  51. Winkler, U.: Virology 24, 518 (1964b).PubMedCrossRefGoogle Scholar
  52. Yarus, M. J., Sinsheimer, R. L.: J. molec. Biol. 8, 614 (1964).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1970

Authors and Affiliations

  • Hermann Dertinger
    • 1
  • Horst Jung
    • 1
  1. 1.Nuclear Science CenterUniversity of Heidelberg and Institute for Radiation BiologyKarlsruheGermany

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