Specificities of Steroid Antibodies
Numerous disciplines borrow concepts and methods from the field of immunology. None has found wider application than the principles which underlie immune assay of important protein molecules in body fluids. Certain nonprotein substances, e.g., α-DNP- (lys)7, arsanilic acid azo-D are able, despite low molecular weight and initial absence of reactive groups, to induce antibody formation (Kabat, 1968). Steroids are not immunogenic by themselves but can serve effectively as haptens. Lieberman, Goodfriend, and their colleagues made the significant original observations without which we would have very little to discuss at this symposium (Beiser et al., 1959; Erlanger et al., 1957, 1959; Goodfriend and Sehon, 1958, 1961a and 1961b; Lieberman et al., 1959).
KeywordsFluorescence Enhancement Sulfamic Acid Hydroxy Steroid Estrone Sulfate Steroid Molecule
Unable to display preview. Download preview PDF.
- Kabat, E. A. 1968. Structural Concepts in Immunology and Immunochemistry. New York, Holt, Rinehart and Winston, Inc.Google Scholar
- Karush, F. 1962. Immunologic specificity and molecular structure. In Taliaferro, W. H., and J. H. Humphrey, eds. Advances in Immunology, vol. 2, 1–40, New York, Academic Press, Inc.Google Scholar
- Lieberman, S., B. F. Erlanger, S. M. Beiser, and F. J. Agate, Jr. 1959. Steroid-protein conjugates: Their chemical, immunochemical, and endocrinological properties. Recent Progr. Hormone Res., 15:165–200.Google Scholar