Correlation of the S-100 Brain Protein with Behavior
During the last few years we have investigated the acidic brain protein S-100 in hippocampal nerve cells during a behavioral test in rats. We wish to report that the amount of nerve cell S-100 protein increases in trained animals and that the S-100 protein is specifically correlated to learning. This linkage was demonstrated by the use of antiserum against the S-100 protein, which was injected intraventricularly during the course of the training and localized in the hippocampus by specific fluorescence. The presence of antiserum against the S-100 protein in the hippocampus prevents further learning during continued training.
KeywordsNerve Cell Performance Curve Specific Fluorescence Brain Protein Trained Animal
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