Advertisement

The Physiological Evaluation of Gene Therapies of Dystrophin-Deficient Muscles

  • J. M. Gillis
  • N. Deconinck
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 453)

Abstract

This paper summarizes the results obtained in collaborative works with T. Ragot and M. Pérricaudet (Villejuif, France; for the minidystrophin experiments, see ref. 1), with J. Tinsley, R. Fisher, S. Phelps, K. Davies (Oxford, England; for the utrophin experiments, see ref. 2) and with our colleagues F. De Backer, D.Kahn and G.Maréchal, see refs. 1–3).

Keywords

Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy Eccentric Contraction Duchenne Muscular Dystrophy Patient Extensor Digitorum Longus Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Deconinck, N., Ragot, T., Maréchal, G., Pérricaudet, M. & Gillis, J.M. Proc.Natl.Acad.Sci.USA, 93, 3570–3574 (1996).PubMedCrossRefGoogle Scholar
  2. 2.
    Deconinck, N. et al. Nature Med. (in the press).Google Scholar
  3. 3.
    Moens, P., Baatsen, P.H.W.W., & Maréchal, G. J. Musc. Res. Cell Mot., 14, 446–451 (1993).CrossRefGoogle Scholar
  4. 4.
    Hoffman, E.P., Brown, R.H. and Kunkel, L.M. Cell 51, 919–928 (1987).PubMedCrossRefGoogle Scholar
  5. 5.
    Zubrzycka-Gaarn E.E. et al. Nature, 333, 466–9 (1988).PubMedCrossRefGoogle Scholar
  6. 6.
    Matsumura, K. and Campbell, K.P. Muscle Nerve, 17, 2–15 (1994).PubMedCrossRefGoogle Scholar
  7. 7.
    Matsumura, K. et al. Nature, 359, 320–322 (1992).PubMedCrossRefGoogle Scholar
  8. 8.
    Bulfield G., Silier W.G., Wight P.A.L. & Moore K.J. Proc. Natl. Acad. Sci. USA, 81, 1189–92 (1984).PubMedCrossRefGoogle Scholar
  9. 9.
    Ragot, Th. et al. Nature, 361, 647–650 (1993).PubMedCrossRefGoogle Scholar
  10. 10.
    Tinsley, J.M., Potter, A.C., Phelps, S.R., Fisher, R. Trickett, J.I. & Davies, K.E. Nature, 384, 349–353 (1996).PubMedCrossRefGoogle Scholar
  11. 11.
    Tinsley, J.M. et al. Nature, 360, 591–592 (1992).PubMedCrossRefGoogle Scholar
  12. 12.
    Fardeau, M. et al. C.R. Acad. Sci. Paris, 311, 197–204 (1990).PubMedGoogle Scholar
  13. 13.
    Vincent, N. et al Nature Genetics, 5, 130–134 (1993).PubMedCrossRefGoogle Scholar
  14. 14.
    Coulton G.R., Curtin N., Morgan J.E. & Partridge T.A. Neuropathol. Appl. Neurobiol., 14, 299–314 (1988).PubMedCrossRefGoogle Scholar
  15. 15.
    Petrof, B.J., Shrager, J.B., Stedman, H.H., Kelly, A.M. & Sweeney, H.L. Proc. Natl. Acad. Sci. USA, 90, 3710-3714(1993).Google Scholar
  16. 16.
    Stedman, H.H. et al. Nature, 352, 536–539 (1991).PubMedCrossRefGoogle Scholar
  17. 17.
    Gillis, J.M. Muscle & Nerve, 19, 1230 (1996).Google Scholar
  18. 18.
    Dunn, J.F. & Radda, G.K. J. neurol. Sci, 103, 1105–1110 (1991).CrossRefGoogle Scholar
  19. 19.
    Franco, A. and Lansman, J.B. Nature, 344, 670–673 (1990).PubMedCrossRefGoogle Scholar
  20. 20.
    Turner P.R., Westwood T., Regen C.M. & Steinhardt R.A.: Nature, 355, 735–8 (1988).CrossRefGoogle Scholar
  21. 21.
    Gailly, Ph., Boland, B., Himpens, B., Casteels, R. & Gillis, J.M. Cell Calcium, 14, 473–483 (1993).PubMedCrossRefGoogle Scholar
  22. 22.
    Head, S.I. J. Physiol., 469, 11–19 (1993).PubMedGoogle Scholar
  23. 23.
    Pressmar, J., Brinkmeier, H., Seewald, M.J. Naumann, T. & Rüdel, R. Pflügers Arch., 426, 499–505 (1994).PubMedCrossRefGoogle Scholar
  24. 24.
    Gillis, J.M. Act. Physiol. Scand, 156, 397–406 (1996).CrossRefGoogle Scholar
  25. 25.
    Leijendekker, W.J., Passaquin, A.C., Metzinger, L & Rüegg, U.T. Br. J. Pharmacol., 118, 611–616 (1996).PubMedGoogle Scholar
  26. 26.
    Imbert, N. et al. Neuromusc. Disord., 6, 351–360 (1996).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1998

Authors and Affiliations

  • J. M. Gillis
    • 1
  • N. Deconinck
    • 1
  1. 1.Department of Physiology, UCL 5540Catholic University of LouvainBruxellesBelgium

Personalised recommendations