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Validation of in Vitro-in Vivo Correlation Models

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In Vitro-in Vivo Correlations

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 423))

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Abstract

A valid model can be defined as one that is a) well-grounded on principles or evidence, b) able to withstand criticism or objection, and c) capable of serving the purpose of the model. In the area of mathematical modelling, there are two criteria in the validation process: internal criteria and external criteria (1). The internal criteria establish the validity of a model within the conditions of the model itself (e.g., the model’s consistency and algorithmic integrity). The external criteria, on the other hand, are based on the model’s purpose, theory, and data, considering those conditions that are not internal properties of the model.

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References

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© 1997 Plenum Press, New York

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Young, D., Dowell, J.A., Piscitelli, D.A., Devane, J. (1997). Validation of in Vitro-in Vivo Correlation Models. In: Young, D., Devane, J.G., Butler, J. (eds) In Vitro-in Vivo Correlations. Advances in Experimental Medicine and Biology, vol 423. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6036-0_7

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  • DOI: https://doi.org/10.1007/978-1-4684-6036-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-6038-4

  • Online ISBN: 978-1-4684-6036-0

  • eBook Packages: Springer Book Archive

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