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in Vivo-in Vitro Evaluation of the Impact of Accelerated Stability Conditions on a Hydrophilic Matrix Tablet

  • P. Stark
  • A. Kinahan
  • S. Cunningham
  • C. Farrell
  • J. Butler
  • M. Reilly
  • J. Devane
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 423)

Abstract

Changes occur in the tensile strength of compacts produced from powdered Hydroxypropyl methylcellulose (HPMC) after storage at different relative humidities (S.Malamataris et al., Int. J. Pharm., 1994). Studies in this laboratory have noted that subjecting a hydrophilic matrix formulation of a Class I drug (Amidon et al., 1995) to accelerated stability conditions resulted in a reduction in tablet crushing strength. An in vitro dissolution method developed in this laboratory indicated that such physical changes in this hydrophilic matrix formulation could potentially result in an altered in vivo profile.

Keywords

High Density Polyethylene Dissolution Profile Stressed Product Hydrophilic Matrix Hydrophilic Matrix Tablet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1997

Authors and Affiliations

  • P. Stark
    • 1
  • A. Kinahan
    • 1
  • S. Cunningham
    • 1
  • C. Farrell
    • 1
  • J. Butler
    • 1
  • M. Reilly
    • 1
  • J. Devane
    • 1
  1. 1.IVIVR Co-operative Working GroupElan Corporation plc Athlone Co.WestmeathIreland

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