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The Development of a Novel in Vitro Discriminatory Dissolution Method for a Class I Drug in a Matrix Tablet Formulation

  • C. Farrell
  • J. Butler
  • P. Stark
  • H. Madden
  • J. Devane
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 423)

Abstract

A controlled release hydrophilic matrix tablet formulation of a Class I (Amidon et al., 1995) drug containing hydroxypropylmethylcellulose (HPMC) has been developed. The level of HPMC has previously been shown to influence the in vivo release of the drug from this formulation. However, a standard dissolution test utilising USP II aqueous methodology failed to discriminate sufficiently between formulations. Therefore, work was undertaken to develop a novel discriminatory dissolution method based on retrospective in vivo data.

Keywords

Dissolution Profile Dissolution Method Vitro Dissolution Elan Corporation Cooperative Working Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1997

Authors and Affiliations

  • C. Farrell
    • 1
  • J. Butler
    • 1
  • P. Stark
    • 1
  • H. Madden
    • 1
  • J. Devane
    • 1
  1. 1.IVIVR Cooperative Working GroupElan Corporation Athlone Co.WestmeathIreland

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