Determination of Critical Manufacturing and Formulation Variables for a Hydrophilic Matrix Tablet Formulation Using an in Vitro Discriminatory Dissolution Method
Formulation and manufacturing variables have been reported to influence the in-vitro release from hydrophilic matrix formulations. Studies on formulation and manufacturing variables have examined drug concentration1–4 and particle size1,3,4 polymer viscosity grade1–5 and particle size2 tablet compression force1,6 and formulation additives2,4,5,7.
KeywordsDissolution Profile Matrix Tablet Hydroxypropyl Methylcellulose Tablet Hardness Hydrophilic Matrix
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