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Determination of Critical Manufacturing and Formulation Variables for a Hydrophilic Matrix Tablet Formulation Using an in Vitro Discriminatory Dissolution Method

  • P. Stark
  • A. Kinahan
  • S. Cunningham
  • J. Butler
  • T. O’Hara
  • A. Dunne
  • J. Connolly
  • J. Devane
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 423)

Abstract

Formulation and manufacturing variables have been reported to influence the in-vitro release from hydrophilic matrix formulations. Studies on formulation and manufacturing variables have examined drug concentration1–4 and particle size1,3,4 polymer viscosity grade1–5 and particle size2 tablet compression force1,6 and formulation additives2,4,5,7.

Keywords

Dissolution Profile Matrix Tablet Hydroxypropyl Methylcellulose Tablet Hardness Hydrophilic Matrix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1997

Authors and Affiliations

  • P. Stark
    • 1
  • A. Kinahan
    • 1
  • S. Cunningham
    • 1
  • J. Butler
    • 1
  • T. O’Hara
    • 1
  • A. Dunne
    • 2
  • J. Connolly
    • 2
  • J. Devane
    • 1
  1. 1.IVIVR Co-operative Working GroupElan Corporation plc, Athlone, Co.WestmeathIreland
  2. 2.IVIVR Co-operative Working GroupUniversity College DublinDublinIreland

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