Examples of in Vitro-in Vivo Relationships with a Diverse Range of Quality

  • Russell J. Rackley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 423)


The purpose of this chapter is to present an introduction of in vivo - in vitro relationships (IVIVRs) and illustrate a number of examples which IVIVRs may be used to evaluate oral, modified-release formulations. Examples given are meant to portray applications to extended-release formulations, which may be defined as a dosage form allowing for a reduction in dosing frequency as compared to that drug presented as a conventional dosage form (1). “Controlled-release” throughout this chapter refers to an extended-release dosage form. In this chapter, in accordance with the meeting, IVIVR is used interchangeably with IVIVC (in vivo - in vitro correlation).


Dosage Form Oral Dosage Form Dissolution Data Solid Oral Dosage Form Pharmacokinetic System 
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Copyright information

© Plenum Press, New York 1997

Authors and Affiliations

  • Russell J. Rackley
    • 1
  1. 1.Biopharmaceutics Purepac Pharmaceutical Co., a subsidiary of Faulding, Inc.ElizabethUSA

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