Cocaine pp 37-79 | Cite as

The Neurobiology of Cocaine

  • Mark S. Gold
Part of the Drugs of Abuse book series (DOAC, volume 3)


The abuse and addiction potential of cocaine results, at least partly, from its effects on specific neurotransmitter systems of the brain. Recent laboratory research has established that cocaine and other drugs of abuse act directly on the brain’s reward pathways. Although it may seem obvious that the euphoric effects of cocaine enhance the abuse potential of the drug, many attempts at understanding addiction have instead focused on etiologies other than endogenous reward, such as the self-medication theory. According to this theory, cocaine administration is an attempt to correct a major psychiatric problem such as depression. Although it is true that a psychological state like depression may be associated with the drug taking, cocaine itself is not an antidepressant. Furthermore, controlled studies have found that depressed or anxious people do not drink more than nondepressed or nonanxious individuals.1


Ventral Tegmental Area Locus Coeruleus Conditioned Place Preference Cocaine Abuse Medial Forebrain Bundle 


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Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Mark S. Gold
    • 1
  1. 1.Departments of Neuroscience and PsychiatryUniversity of Florida College of MedicineGainesvilleUSA

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