Dynamical Models for Cell Rearrangement During Morphogenesis
The spatial form of cells and tissues reflect their underlying physical and mechanical properties. These properties are regulated, primarily by the modification of cell cytoskeletal components, to produce a large repertoire of cell behaviors, including cell shape changes and directed motility. In a number of instances, these behaviors drive tissue morphogenesis during embryological development. Here we propose a mechanical model for studying tissue morphogenesis by cell rearrangement and cell shape change. Our model describes these processes by accounting for the balance of forces between neighboring cells that are junctionally coupled within a tissue. The model is applied to two embryological settings: epiboly in the teleost fish Fundulus, and notochord extension in Xenopus laevis.
KeywordsXenopus Laevis Cell Node Elastic Force Interior Cell Cell Sheet
Unable to display preview. Download preview PDF.
- Oster, G. 1984. On the crawling of cells. J. Embryol Exp. Morphol. 83:327–364.Google Scholar
- Oster, G. and M. Weliky. 1990. Morphogenesis by cell rearrangement: A computer simulation approach. Sem. Cell Biol. 1:313–323.Google Scholar
- Sulsky, D. 1982. Models of Cell and Tissue Movement. Ph.D. dissertation, New York University.Google Scholar
- Weliky, M. and G. Oster. 1991. Notochord morphogenesis in Xenopus laevis: Computer simulation of cell behaviors driving tissue convergence and extension. Development, In press.Google Scholar