Neutrophil-Epithelial Cell Interactions in the Intestine

  • James L. Madara
  • Shirin Nash
  • Charles Parkos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 314)


Polymorphonuclear leukocytes (PMN) migrate across the intestinal epithelium in a variety of inflammatory diseases afflicting the small intestine and colon. Subsequent collection of PMN in crypt lumens (“crypt abscesses”) is a histologic finding used by pathologists to determine disease activity (1, 2). Here we consider the potential impact such PMN-epithelial interactions might have on intestinal epithelial function.


Secretory Diarrhea Crypt Abscess Chemotactic Peptide Chemotactic Gradient Intercellular Tight Junction 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • James L. Madara
    • 1
  • Shirin Nash
    • 1
  • Charles Parkos
    • 1
  1. 1.Division of Gastointestinal Pathology Department of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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