Neutrophil-Epithelial Cell Interactions in the Intestine
Polymorphonuclear leukocytes (PMN) migrate across the intestinal epithelium in a variety of inflammatory diseases afflicting the small intestine and colon. Subsequent collection of PMN in crypt lumens (“crypt abscesses”) is a histologic finding used by pathologists to determine disease activity (1, 2). Here we consider the potential impact such PMN-epithelial interactions might have on intestinal epithelial function.
KeywordsSecretory Diarrhea Crypt Abscess Chemotactic Peptide Chemotactic Gradient Intercellular Tight Junction
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