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Lipoxins Inhibit Microvascular Inflammatory Actions of Leukotriene B4

  • Johan Raud
  • Ulla Palmertz
  • Sven-Erik Dahlén
  • Per Hedqvist
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 314)

Abstract

The lipoxins constitute a new class of arachidonic acid derivatives which may be produced by for example leukocytes, or by leukocytes interacting with platelets (cf. Dahlén and Serhan 1990). The biosynthesis of lipoxins is the result of interactions between different lipoxygenases, and the lipoxins characteristically possess a conjugated tetraene structure (Serhan et al., 1984; cf. Dahlén and Serhan 1990). The two major compounds, lipoxin A4 and B4 (LXA4, 5S, 6R, 15S-trihydroxy-7, 9, 13-trans-ll-cis-eicosatetraenoic acid; LXB4, 5S,14R,15S-trihydroxy-6, 10, 12-trans-8-cis-eicosatetraenoic acid), display a number of biological actions, indicating their involvement as modulators of events such as intracellular signal transduction, immunological defence and inflammation (cf. Dahlén and Serhan 1990).

Keywords

Nedocromil Sodium Cheek Pouch Plasma Leakage Eicosatetraenoic Acid Hamster Cheek Pouch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Johan Raud
    • 1
  • Ulla Palmertz
    • 1
  • Sven-Erik Dahlén
    • 1
  • Per Hedqvist
    • 1
  1. 1.Department of Physiology I and Institute of Environmental MedicineKarolinska InstitutetStockholmSweden

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