Role of Eicosanoids and the Cytokine Network in Transmembrane Signaling in Vascular Cells

  • Kenneth B. Pomerantz
  • David P. Hajjar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 314)


The concept that atherosclerosis is an inflammatory response to injury is based on observations that cells of monocytic origin, including macrophages and T-cells populate the developing atherosclerotic lesion. This is in addition to the well-characterized smooth muscle cell infiltrate1. Since endothelial cell activation or injury is a prerequisite for monocyte adhesion and diapedesis, the histologic evidence described above support the hypothesis that endothelial cell injury is an important initial event in the development of the inflammatory lesion. Activation or injury may thus initiate a series of process that lead to intimai hyperplasia and choiesteryl ester deposition within the macrophage and smooth muscle cell.


Smooth Muscle Cell Cholesteryl Ester Smooth Muscle Cell Proliferation Aortic Smooth Muscle Cell Arterial Smooth Muscle Cell 


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Kenneth B. Pomerantz
    • 1
  • David P. Hajjar
    • 2
  1. 1.Departments of MedicineCornell University Medical CollegeNew YorkUSA
  2. 2.Pathology, and Biochemistry and the National Institutes of Health Specialized Center of Research in ThrombosisCornell University Medical CollegeNew YorkUSA

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